Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Май 21, 2025
T cell receptor (TCR) signaling, also known as signal 1, plays a crucial role in the activation and proliferation of cells. The question whether TCR signaling exerts deterministic fate determination is an area active investigation. It has been particularly challenging to address this due complexities associated with genetic manipulation components, which often disrupts thymic development or impairs upon engagement. Recent study demonstrates that TCR-Lck/Fyn axis directly induces STAT3 phosphorylation synergizes pro-inflammatory cytokines optimize during Th17 differentiation. Additionally, TCR-Lck/Fyn-AKT/mTOR negatively regulates Treg In CD8+ cells, persistent high-affinity antigen stimulation drives differentiation along exhaustion pathway, while acute infection intermediate levels promote into effector memory although underlying mechanism remains be fully elucidated. Collectively, these studies provide compelling evidence impact on fate. This review summarizes recent advances understanding how shapes determination.
Язык: Английский