Pulmonary Circulation,
Год журнала:
2024,
Номер
14(3)
Опубликована: Июль 1, 2024
Abstract
Pulmonary
arterial
hypertension
(PAH)
is
a
poorly
understood
disease
of
the
small
pulmonary
arteries.
vascular
remodeling
and
progressively
rising
resistance
are
hallmarks
that
ultimately
result
in
right
heart
failure.
Several
genetic
mutations,
most
notably
bone
morphogenetic
protein
receptor
type
2,
have
causal
association
with
heritable
forms
PAH.
Mutations
neurogenic
locus
notch
homolog
3
(
NOTCH3)
been
reported
adults
children
PAH,
but
whether
NOTCH3
causally
associated
PAH
debated.
With
this
case
report,
we
describe
clinical
characteristics,
comorbidities,
exposure
history
an
adult
patient
multiple
sclerosis
who
was
found
to
missense
mutation
leflunomide.
Cardiovascular Therapeutics,
Год журнала:
2023,
Номер
2023, С. 1 - 13
Опубликована: Дек. 13, 2023
Coronary
artery
disease
(CAD)
is
the
most
prevalent
cardiovascular
worldwide,
resulting
in
myocardial
infarction
(MI)
and
even
sudden
death.
Following
percutaneous
coronary
intervention
(PCI),
restenosis
caused
by
vascular
remodeling
always
formed
at
stent
implantation
site.
Here,
we
show
that
Ginkgolide
B
(GB),
a
naturally
occurring
terpene
lactone,
effectively
suppresses
subsequent
wild-type
mice
following
left
carotid
(LCA)
injury.
Additional
experiments
reveal
GB
exerts
protective
effect
on
further
through
modulation
of
Tgfβ1/Smad
signaling
pathway
vivo
human
smooth
muscle
cells
(HVSMAs)
but
not
umbilical
vein
endothelial
(HUVECs)
vitro.
Moreover,
beneficial
abolished
after
incubated
with
pirfenidone
(PFD,
drug
for
idiopathic
pulmonary
fibrosis,
IPF),
which
can
inhibit
Tgfβ1.
In
Tgfβ1-/-
mice,
treatment
capsules
Yinxingneizhi
Zhusheye
(including
B)
fails
to
improve
restenosis.
conclusion,
our
data
identify
could
be
potential
novel
therapeutic
agent
block
vessel
injury-associated
significant
repression
pathway.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6248 - 6248
Опубликована: Июнь 6, 2024
NOTCH3
receptor
signaling
has
been
linked
to
the
regulation
of
smooth
muscle
cell
proliferation
and
maintenance
cells
in
an
undifferentiated
state.
Pulmonary
arterial
hypertension
(World
Health
Organization
Group
1
idiopathic
disease:
PAH)
is
a
fatal
disease
characterized
clinically
by
elevated
pulmonary
vascular
resistance
caused
extensive
proliferation,
perivascular
inflammation,
asymmetric
neointimal
hyperplasia
precapillary
arteries.
In
this
review,
detailed
overview
specific
role
PAH,
including
its
mechanisms
activation
select
ligand,
downstream
effectors,
physiologic
effects
within
tree,
provided.
Animal
models
showing
importance
pathway
clinical
PAH
will
be
discussed.
New
drugs
biologics
that
inhibit
reverse
deadly
are
highlighted.
The
mechanisms
of
meniscus
fibrosis
and
novel
ways
to
enhance
is
unclear.
This
work
reveals
human
initiated
at
E24
weeks.
Smooth
muscle
cell
cluster
identified
in
embryonic
meniscus,
the
combined
analysis
with
previous
data
suggests
smooth
as
precursors
progenitor
cells
mature
meniscus.
NOTCH3
constantly
expressed
throughout
embryogenesis
adulthood.
Inhibition
signaling
vivo
inhibits
exacerbates
degeneration.
Continuous
histological
sections
show
that
HEYL,
downstream
target
gene,
consistently
NOTCH3.
HEYL
knockdown
attenuated
COL1A1
upregulation
by
CTGF
TGF-β
stimulation.
Thus,
this
study
discovers
existence
fibers
a
HEYL-dependent
manner
prevented
exacerbated
Therefore,
NOTCH3/HEYL
might
be
potential
therapeutic
for
fibrosis.
Avian Pathology,
Год журнала:
2024,
Номер
53(6), С. 441 - 450
Опубликована: Июнь 18, 2024
Ascites
syndrome
(AS)
in
broiler
chickens,
also
known
as
pulmonary
arterial
hypertension
(PAH),
is
a
significant
disease
the
poultry
industry.
It
nutritional
metabolic
that
closely
associated
with
hypoxia-inducible
factors
and
rapid
growth.
The
rise
artery
pressure
crucial
characteristic
of
AS
instrumental
its
development.
Hypoxia-inducible
factor
1α
(HIF-1α)
an
active
subunit
key
transcription
oxygen-sensing
pathway.
HIF-1α
plays
vital
role
oxygen
homeostasis
development
hypertension.
Studying
effects
on
humans
or
mammals,
well
ascites
broilers,
can
help
us
understand
pathogenesis
AS.
Therefore,
this
review
aims
to
(1)
summarize
mechanism
hypertension,
(2)
provide
theoretical
significance
explaining
(ascites
syndrome)
(3)
establish
correlation
between
broilers.
HIGHLIGHTSExplains
hypoxic
HIF-1α.Linking
broilers.Explains
microRNAs
Pulmonary Circulation,
Год журнала:
2024,
Номер
14(3)
Опубликована: Июль 1, 2024
Abstract
Pulmonary
arterial
hypertension
(PAH)
is
a
poorly
understood
disease
of
the
small
pulmonary
arteries.
vascular
remodeling
and
progressively
rising
resistance
are
hallmarks
that
ultimately
result
in
right
heart
failure.
Several
genetic
mutations,
most
notably
bone
morphogenetic
protein
receptor
type
2,
have
causal
association
with
heritable
forms
PAH.
Mutations
neurogenic
locus
notch
homolog
3
(
NOTCH3)
been
reported
adults
children
PAH,
but
whether
NOTCH3
causally
associated
PAH
debated.
With
this
case
report,
we
describe
clinical
characteristics,
comorbidities,
exposure
history
an
adult
patient
multiple
sclerosis
who
was
found
to
missense
mutation
leflunomide.
