Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2837 - 2837

Опубликована: Март 21, 2025

There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.

Язык: Английский

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The impact of donor liver fibrosis on the outcomes of patients who undergo liver transplant: a cohort study from UNOS database

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Апрель 10, 2025

Background The increasing prevalence of fibrosis in donor livers raises concerns about its impact on post-transplantation outcomes, though this relationship remains unclear. This study aims to assess the effect liver patient and graft survival following transplantation. Methods Data from UNOS-SRTR registry (1987–2024) were analyzed, focusing patients who received transplants with biopsy-proven fibrosis. cohort was stratified based grade, outcomes compared using Cox regression Kaplan–Meier analysis. Competing risk models applied specific causes for failure, subgroup analyses explored sensitivity transplant outcomes. Results Of 22,897 patients, 17,926 non-fibrotic grafts, 4,971 had grafts varying grades. Donor associated age, steatosis, portal infiltrate, generally affecting those better overall condition. Significant differences observed ( p = 0.001) 0.002) between non-fibrosis groups. Further analysis revealed that increased malignancy 0.028), cardiovascular disease 0.017), respiratory failure 0.033), but showed lower rejection rates at six months one year. Sensitivity confirmed as an independent factor, effects subgroups. Conclusion significantly impacts post-transplant notably all-cause mortality failure. Specific death, such disease, more prevalent recipients fibrotic highlighting need further research refine selection criteria.

Язык: Английский

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Intestinal Activation of LXRα Counteracts Metabolic-Associated Steatohepatitis Features in Mice

Nutrients, Год журнала: 2025, Номер 17(8), С. 1349 - 1349

Опубликована: Апрель 15, 2025

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health problem and the discovery of drugs challenging. In this study, we aimed to investigate effects intestinal activation X receptor (LXR)α on MASH. Methods: An intestinal-specific LXRα model in mice was established subjected MASH development by combining Western diet carbon tetrachloride. Lipid metabolism, reverse cholesterol transport (RCT), steatosis, inflammation, fibrosis were evaluated. vitro models steatosis used explore role scavenger class B type 1 (SRB1). Results: We found that improved several MASLD features, including levels triglycerides, RCT, systemic hepatic inflammatory profiles, fibrosis. These associated with increased high-density lipoprotein (HDL) SRB1 expression. depletion hampered beneficial HDL fibrogenesis cells altering both peroxisome proliferator-activated receptors γ small mothers against decapentaplegic homolog protein (SMAD)2/3 proteins. Conclusions: Our findings showed parallel induction are protective advanced MASLD.

Язык: Английский

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Comprehensive Profiling of Candidate Biomarkers and Immune Infiltration Landscape in Metabolic Dysfunction-Associated Steatohepatitis

Metabolism Open, Год журнала: 2025, Номер unknown, С. 100366 - 100366

Опубликована: Апрель 1, 2025

Язык: Английский

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Emerging Drug Therapies for Metabolic Dysfunction-Associated Steatotic Liver Disease: A Glimpse into the Horizon

Current Hepatology Reports, Год журнала: 2024, Номер 23(1), С. 204 - 219

Опубликована: Янв. 6, 2024

Язык: Английский

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