Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis DOI Open Access

Thanina Medjbeur,

Ugo Sardo,

Prunelle Perrier

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 22, 2024

ABSTRACT Inflammatory bowel diseases are chronic inflammatory conditions with growing prevalence in western populations. Iron is an essential component of erythrocytes hemoglobin. Under the influence elevated hepcidin production, iron sequestered cells during inflammation which, turn, leads to restriction for red blood synthesis. As a consequence, deficiency and anemia most prevalent extraintestinal complications IBD patients. Patients thus treated oral supplements that have limited efficacy as absorption blunted intestinal inflammation. Moreover, supplementation can cause previous studies shown worsens response. However, comparative analysis effects low, adequate high dietary content matching given patients has not been performed mice. We therefore tested impact deprivation murine model colitis induced by dextran sodium sulfate. found both were accompanied more severe earlier signs gastrointestinal bleeding compared mice fed diet. The manipulation led comparable oxidative stress pronounced dysbiosis colon control differed depending on content. Analysis these line susceptibility colonic questioning benefit/risk balance

Язык: Английский

Adipokines: masterminds of metabolic inflammation DOI
Herbert Tilg, Gianluca Ianiro, Antonio Gasbarrini

и другие.

Nature reviews. Immunology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Язык: Английский

Процитировано

18
Adiponectin reduces immune checkpoint inhibitor-induced inflammation without blocking anti-tumor immunity DOI Creative Commons
Lukas M. Braun, Sophie Giesler, Geoffroy Andrieux

и другие.

Cancer Cell, Год журнала: 2025, Номер 43(2), С. 269 - 291.e19

Опубликована: Фев. 1, 2025

Highlights•Drugs currently used against irAEs reduce anti-tumor immunity•ECP induces adiponectin production in inflamed organs while sparing tumor tissue•ECP high response rates patients with ICI-induced irAEsSummaryImmune-related adverse events (irAEs) cancer receiving immune checkpoint inhibitors (ICIs) cause morbidity and necessitate cessation of treatment. Comparing irAE treatments, we find that immunity is preserved mice after extracorporeal photopheresis (ECP) but reduced glucocorticosteroids, TNFα blockade, α4β7-integrin inhibition. Local elicits a tissue-specific effect by reducing pro-inflammatory T cell frequencies the colon tumor-specific development. A prospective phase-1b/2 trial (EudraCT-No.2021-002073-26) 14 reveals low ECP-related toxicity. Overall rate for all 92% (95% confidence interval [CI]: 63.97%–99.81%); colitis-specific complete remission 100% CI: 63.06%–100%). Glucocorticosteroid dosages could be ECP therapy. The ECP-adiponectin axis reduces intestinal tissue-resident memory activation CD4+IFN-γ+ cells colitis without evidence loss immunity. In conclusion, identify as an immunomodulatory molecule controls blocking immunity.Graphical abstract

Язык: Английский

Процитировано

2
Vedolizumab for the prevention of intestinal acute GVHD after allogeneic hematopoietic stem cell transplantation: a randomized phase 3 trial DOI Creative Commons
Yi‐Bin Chen, Mohamad Mohty, Robert Zeiser

и другие.

Nature Medicine, Год журнала: 2024, Номер 30(8), С. 2277 - 2287

Опубликована: Июнь 6, 2024

Acute graft-versus-host disease (aGVHD) of the lower gastrointestinal (GI) tract is a major cause morbidity and mortality in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). Vedolizumab gut-selective anti-α

Язык: Английский

Процитировано

14
Advancing therapeutic strategies for graft-versus-host disease by targeting gut microbiome dynamics in allogeneic hematopoietic stem cell transplantation: current evidence and future directions DOI Creative Commons

Muhammad Azhar Ud Din,

Yan Lin,

Changkun Lyu

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 3, 2025

Abstract Hematopoietic stem cell transplantation (HSCT) is a highly effective therapy for malignant blood illnesses that pose high risk, as well diseases are at risk due to other variables, such genetics. However, the prevalence of graft-versus-host disease (GVHD) has impeded its widespread use. Ensuring stability microbial varieties and associated metabolites crucial supporting metabolic processes, preventing pathogen intrusion, modulating immune system. Consequently, it significantly affects overall well-being susceptibility host disease. Patients undergoing allogeneic hematopoietic (allo-HSCT) may experience disruption in balance between system gut bacteria when treated with medicines foreign cells. This can lead secondary intestinal inflammation GVHD. Thus, GM both reliable indicator post-transplant mortality means enhancing GVHD prevention treatment after allo-HSCT. be achieved through various strategies, including nutritional support, probiotics, selective use antibiotics, fecal microbiota (FMT) target microbes. review examines research advancements practical following These findings offer novel insights into

Язык: Английский

Процитировано

0
Vedolizumab for prevention of lower-GI acute GVHD in the Japanese subgroup analysis of the phase 3 GRAPHITE study DOI Creative Commons
Tatsunori Goto, Hiroshi Okamura, Takashi Ikeda

и другие.

International Journal of Hematology, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Abstract In the randomized, double-blind, phase 3 GRAPHITE study (NCT03657160), anti-α 4 β 7 integrin antibody vedolizumab showed greater efficacy than placebo for prevention of lower-gastrointestinal (GI) acute graft-versus-host disease (aGVHD) after unrelated allogenic hematopoietic stem cell transplantation (allo-HSCT). This post hoc analysis assessed and safety versus lower-GI aGVHD in Japanese non-Japanese patients, when added to standard GVHD prophylaxis (calcineurin inhibitor + methotrexate/mycophenolate mofetil / − anti-thymocyte globulin [ATG]). The included 35 (18 vedolizumab-treated, 17 placebo-treated) 298 (150 148 patients. Lower-GI aGVHD-free survival by day 180 allo-HSCT (primary endpoint) was 94% vedolizumab-treated 81% placebo-treated patients (HR 0.36; 95% CI 0.03–4.01; P = 0.2) 84% 70% 0.47; 0.28–0.78; 0.002). number events 5 key secondary endpoints (lower-GI relapse-free survival, Grade C–D non-relapse mortality, overall B–D survival) lower vedolizumab- No concerns were identified use as

Язык: Английский

Процитировано

0
Cellular sentinels: empowering survival and immune defense in hematopoietic stem cell transplantation through mesenchymal stem cells and T lymphocytes DOI Creative Commons
Tzong-Shyuan Tai, Yun‐Hsiang Chen, Chao‐Ling Yao

и другие.

BMC Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Март 18, 2025

Язык: Английский

Процитировано

0
Comparative analysis of dietary iron deprivation and supplementation in a murine model of colitis DOI Creative Commons

Thanina Medjbeur,

Ugo Sardo,

Prunelle Perrier

и другие.

FASEB BioAdvances, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract Inflammatory bowel diseases are chronic inflammatory conditions with growing prevalence in western populations. Iron is an essential component of erythrocytes hemoglobin. Under the influence elevated hepcidin production, iron sequestered cells during inflammation which, turn, leads to restriction for red blood cell synthesis. As a consequence, deficiency and anemia most prevalent extraintestinal complications IBD patients. commonly treated oral supplements, limited efficacy as absorption blunted intestinal inflammation. Moreover, supplementation can cause complications, previous studies have shown that it worsen response. However, comparative analysis effects low, adequate, high dietary content matching given patients has not been performed mice. We therefore tested impact deprivation murine model colitis induced by dextran sodium sulfate. found both were accompanied more severe earlier signs gastrointestinal bleeding compared mice fed iron‐adequate diet. The manipulation led profound dysbiosis colon control differed depending on content. Analysis this line pronounced susceptibility colonic inflammation, thus questioning benefit/risk balance

Язык: Английский

Процитировано

0
Steroid Refractory Acute GVHD: The Hope for a Better Tomorrow DOI Open Access
Portia Smallbone, Rohtesh S. Mehta, Amin M. Alousi

и другие.

American Journal of Hematology, Год журнала: 2025, Номер 100(S3), С. 14 - 29

Опубликована: Март 24, 2025

Steroid-refractory acute graft-versus-host disease (SR-AGVHD) presents a significant barrier to successful outcomes following allogeneic hematopoietic cell transplantation (HCT), despite advancements in GVHD prophylaxis and management. While ruxolitinib therapy has shown improved response rates, survival benefits remain elusive. This review explores the definitions proposed distinct pathophysiology treatment landscape of SR-AGVHD. Emerging therapies offer potential, yet further research is critical better define steroid-refractory populations, improve precision with biomarkers, overcome resistance, particularly ruxolitinib-refractory cases.

Язык: Английский

Процитировано

0
Deciphering the role of the major histocompatibility complex, the intestinal microbiome and metabolites in the pathogenesis of acute graft-versus-host disease DOI Creative Commons
Valentin Wenger, Robert Zeiser

Best Practice & Research Clinical Haematology, Год журнала: 2024, Номер 37(3), С. 101567 - 101567

Опубликована: Июль 26, 2024

Allogeneic hematologic stem cell transplantation is a cornerstone in modern hematological treatment, yet its efficacy compromised by acute Graft-versus-Host Disease. In Disease, conditioning regimen induced epithelial damage leads to release of and pathogen associated molecular patters which turns triggers activation alloreactive donor T cells, ultimately resulting destruction healthy tissue. Advances major histocompatibility complex typing preclinical studies using tissue specific deletion have illuminated the contributions both, hematopoietic non-hematopoietic cells Disease pathophysiology. Concurrently, high-throughput sequencing techniques enabled researchers recognize significant impact intestinal microbiome newly discovered metabolites pathophysiology this review, we discuss implications expression on effect metabolic alterations that contribute By combining these findings, hope untangle complexity paving way for development novel more effective treatmen options patients.

Язык: Английский

Процитировано

1
Recent advances in acute gastrointestinal graft versus host disease (aGvHD): aspects of steroid-resistant disease DOI Creative Commons
J Kujawska, Robert Zeiser, Lidia Gil

и другие.

Annals of Hematology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

Acute Graft versus Host Disease (aGvHD) is a common immunological complication occurring in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Moreover, aGvHD associated with higher risk of infections and metabolic complications, affecting non-relapse mortality. Progress has changed the prophylactic therapeutic strategies improved patient outcomes. The standard first-line therapy remains steroids, response rate about 50%. Janus Kinase 2 (JAK2) inhibitor, ruxolitinib, an effective second-line therapy. management who developed disease that refractory to steroids especially severe gastrointestinal forms aGvHD, not validated unmet medical need. In article, we present current clinical practice, as well latest advances targeting pathophysiological pathways GvHD gut microbiota, which may be potential future

Язык: Английский

Процитировано

1