Animal Models of Non-Respiratory, Post-Acute Sequelae of COVID-19
Viruses,
Год журнала:
2025,
Номер
17(1), С. 98 - 98
Опубликована: Янв. 14, 2025
Post-acute
sequelae
of
COVID-19
(PASC)
are
a
diverse
set
symptoms
and
syndromes
driven
by
dysfunction
multiple
organ
systems
that
can
persist
for
years
negatively
impact
the
quality
life
millions
individuals.
We
currently
lack
specific
therapeutics
patients
with
PASC,
due
in
part
to
an
incomplete
understanding
its
pathogenesis,
especially
non-pulmonary
sequelae.
Here,
we
discuss
three
animal
models
have
been
utilized
investigate
PASC:
non-human
primates
(NHPs),
hamsters,
mice.
focus
on
neurological,
gastrointestinal,
cardiovascular
PASC
highlight
advances
mechanistic
insight
made
using
these
models,
as
well
discussing
warrant
continued
intensive
research.
Язык: Английский
Preventative Vaccination of Nonhuman Primates
Journal of Zoological and Botanical Gardens,
Год журнала:
2025,
Номер
6(1), С. 8 - 8
Опубликована: Фев. 3, 2025
Vaccination
constitutes
one
of
the
most
important
means
preventing
infectious
disease
in
captive
nonhuman
primates
(NHPs).
protocols
for
NHPs
vary,
as
they
are
mostly
guided
by
institutional
preference,
infection
pressure,
local
availability,
and
recommendations
non-peer
reviewed
resources.
Currently,
no
updated
literature
review
about
vaccination
options
NHP
is
available.
Therefore,
we
provide
a
detailed
overview
published
NHP.
Our
findings
demonstrate
that,
while
there
often
insufficient
scientific
data
to
justify
their
use,
core
vaccines
used
species
confer
protection
against
tetanus,
rabies,
measles.
Where
information
available,
efficacy
expectations,
adverse
effects,
dosages
frequency
administration
provided.
We
advocate
that
decision
vaccinate
less
common
diseases,
which
an
off-label
vaccine
should
be
grounded
comprehensive
risk
assessment.
This
assessment
consider
factors
specific
individual
animal,
vaccine,
housing
institution,
epidemiology
disease,
relevant
regulatory
ethical
considerations.
Язык: Английский
Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Abstract
Long-term
adverse
consequences
of
SARS-CoV-2
infection,
termed
“long
COVID”
or
post-acute
sequelae
COVID
(PASC),
are
a
major
component
overall
COVID-19
disease
burden.
Prior
obesity
and
metabolic
increase
the
severity
acute
disease,
but
infection
also
contributes
to
development
new-onset
disease.
Since
pandemic
occurred
in
context
global
epidemic,
an
important
question
is
extent
which
pre-existing
modifies
long-term
responses
infection.
We
utilized
nonhuman
primate
model
compare
effects
with
delta
variant
lean
obese/insulin-resistant
adult
male
rhesus
macaques
over
6-month
time
course.
While
some
longitudinal
including
viral
dynamics,
SARS-CoV-2-specific
IgG
induction,
cytokine
profiles,
tissue
persistence
RNA,
did
not
appreciably
differ
between
obese
animals,
other
responses,
neutralizing
Ab
lung
pathology,
body
weight,
degree
insulin
sensitivity,
adipocytokine
temperature,
nighttime
activity
levels
were
significantly
different
versus
animals.
Furthermore,
several
parameters
animals
altered
following
resemble
those
Notably,
persistent
changes
multiple
present
most
suggesting
that
PASC
may
be
more
prevalent
than
estimated
from
self-reported
symptoms
human
studies.
Язык: Английский
mTORC1 syndrome (TorS): unifying paradigm for PASC, ME/CFS and PAIS
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 9, 2025
Post-acute
SarS-Cov2
(PASC),
Myalgia
encephalomyelitis/Chronic
fatigue
syndrome
(ME/CFS)
and
infection
(PAIS)
consist
of
chronic
post–acute
infectious
syndromes,
sharing
exhaustive
fatigue,
post
exertional
malaise,
intermittent
pain,
postural
tachycardia
neuro-cognitive-psychiatric
dysfunction.
However,
the
concerned
shared
pathophysiology
is
still
unresolved
in
terms
upstream
drivers
transducers.
Also,
risk
factors
which
may
determine
vulnerability/progression
to
phase
remain
be
defined.
In
lack
a
cohesive
pathophysiology,
syndromes
unmet
therapeutic
needs.
'mTORC1
Syndrome'
(TorS)
implies
an
disease
entity
driven
by
sustained
hyper-activation
mammalian
target
rapamycin
C1
(mTORC1),
resulting
variety
aspects
Metabolic
Syndrome
(MetS),
non-alcoholic
fatty
liver
disease,
obstructive
pulmonary
some
cancers,
neurodegeneration
other
[Bar-Tana
Trends
Endocrinol
Metab
34:135–145,
2023].
TorS
offer
insight
PASC,
ME/CFS
PAIS
drivers,
vulnerability
treatment
options.
Язык: Английский
Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
After
infection
with
SARS-CoV-2,
patients
may
present
one
or
more
symptoms
that
appear
persist
over
time,
including
fatigue,
respiratory,
cardiovascular
and
neurological
disorders.
Neurological
include
anxiety,
depression
impaired
short-term
memory.
However,
the
exact
underlying
mechanisms
of
long
Covid
are
not
yet
decrypted.
Using
golden
hamster
as
a
model,
we
provide
further
evidence
SARS-CoV-2
is
neuroinvasive
can
in
central
nervous
system,
found
viral
RNA
replicative
virus
brainstem
after
80
days
infection.
Infected
hamsters
presented
neurodegenerative
signature
brainstem,
overexpression
innate
immunity
genes,
impacted
dopaminergic
glutamatergic
synapses,
altered
energy
metabolism.
Finally,
infected
manifested
persistent
signs
memory,
well
late-onset
valuable
model
to
study
Covid.
Conclusively,
virus-related
immunometabolic
coexist
contribute
manifestation
neuropsychiatric
cognitive
symptoms.
Highlights
infects
persists
intranasally-inoculated
Persistent
consequences
observed
SARS-CoV-2-infected
The
distinct
transcriptome
profiles
acute
systems
affected
affects
expression
genes
related
processes
Язык: Английский