Bioorganic & Medicinal Chemistry Letters,
Год журнала:
2023,
Номер
85, С. 129214 - 129214
Опубликована: Март 2, 2023
The
COVID-19
pandemic
caused
by
the
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
continues
to
threaten
human
health
and
create
socioeconomic
problems
worldwide.
A
library
of
200,000
small
molecules
from
Korea
Chemical
Bank
(KCB)
were
evaluated
for
their
inhibitory
activities
against
SARS-CoV-2
in
a
phenotypic-based
screening
assay
discover
new
therapeutics
combat
COVID-19.
primary
hit
this
screen
was
quinolone
structure-containing
compound
1.
Based
on
structure
1
enoxacin,
which
is
quinolone-based
antibiotic
previously
reported
have
weak
activity
SARS-CoV-2,
we
designed
synthesized
2-aminoquinolone
acid
derivatives.
Among
them,
9b
exhibited
potent
antiviral
(EC
Future Medicinal Chemistry,
Год журнала:
2023,
Номер
15(11), С. 959 - 985
Опубликована: Июнь 1, 2023
Aim:
Discovery
of
novel
SARS-CoV-2
main
protease
(Mpro)
inhibitors
using
a
structure-based
drug
discovery
strategy.
Materials
&
methods:
Virtual
screening
employing
covalent
and
noncovalent
docking
was
performed
to
discover
Mpro
inhibitors,
which
were
subsequently
evaluated
in
biochemical
cellular
assays.
Results:
91
virtual
hits
selected
for
assays,
four
confirmed
as
reversible
SARS
CoV-2
with
IC50
values
0.4–3
μM.
They
also
shown
inhibit
SARS-CoV-1
human
cathepsin
L.
Molecular
dynamics
simulations
indicated
the
stability
inhibitor
complexes
interaction
ligands
at
subsites.
Conclusion:
This
approach
led
thiosemicarbazones
potent
inhibitors.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Июнь 24, 2024
Disseminated
candidiasis
is
a
severe
complication
in
patients
with
hematological
malignancies
who
have
undergone
chemotherapy
or
hematopoietic
stem
cell
transplantation.
It
has
high
mortality
rate.
When
disseminated
caused
by
Candida
tropicalis
involves
either
the
brain
heart,
prognosis
extremely
poor.
Traditional
methods
such
as
cultures
are
limited
diagnosing
candidiasis.
We
describe
case
report
of
55-year-old
man
acute
myeloid
leukemia
developed
candidemia
after
chemotherapy,
which
extensively
to
brain,
skin,
liver,
spleen
and
kidneys.
In
this
instance,
patient
was
rapidly
diagnosed
candida
infection
metagenomic
next
generation
sequencing,
successfully
treated
combination
therapy
isavuconazole
amphotericin
B.
The
continued
treatment
while
simultaneously
receiving
antifungal
therapy,
both
were
effectively
controlled.
This
provides
real-world
experience
for
complicated
Biomedicines,
Год журнала:
2022,
Номер
10(11), С. 2815 - 2815
Опубликована: Ноя. 4, 2022
The
vaccine
weapon
has
resulted
in
being
essential
fighting
the
COVID-19
outbreak,
but
it
is
not
fully
preventing
infection
due
to
an
alarming
spreading
of
several
identified
variants
concern.
In
fact,
recent
emergence
pointed
out
how
SARS-CoV-2
pandemic
still
represents
a
global
health
threat.
Moreover,
oral
antivirals
also
develop
resistance,
supporting
need
find
new
targets
as
therapeutic
tools.
However,
cocktail
therapy
useful
reduce
drug
resistance
and
maximize
vaccination
efficacy.
Natural
products
metal-drug-based
treatments
have
shown
interesting
antiviral
activity,
representing
valid
contribution
counter
outbreak.
This
report
summarizes
available
evidence
which
supports
use
approved
drugs
further
focuses
on
significant
clinical
trials
that
investigated
safety
efficacy
repurposing
molecules
different
phenotypes.
To
date,
there
are
many
individuals
vulnerable
exhibiting
severe
symptoms,
thus
characterizing
strategies
for
better
management
disease
challenge.
Pathogens,
Год журнала:
2022,
Номер
11(10), С. 1201 - 1201
Опубликована: Окт. 18, 2022
COVID-19,
which
emerged
in
December
2019,
was
declared
a
global
pandemic
by
the
World
Health
Organization
(WHO)
March
2020.
The
disease
caused
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
It
has
millions
of
deaths
worldwide
and
social
economic
disruption.
While
clinical
trials
on
therapeutic
drugs
are
going
an
Accelerating
COVID-19
Therapeutic
Interventions
Vaccines
(ACTIV)
public–private
partnership
collaboration,
current
approaches
options
to
counter
remain
few.
include
FDA-approved
antiviral
drugs,
Remdesivir,
immune
modulator,
Baricitinib.
Hence,
alternatives
for
treatment
need
be
broadened.
This
paper
discusses
efforts
find
such
as
inhibiting
viral
entry
disrupting
virus
life
cycle,
highlights
gap
that
needs
filled
these
approaches.
Bioorganic & Medicinal Chemistry Letters,
Год журнала:
2023,
Номер
85, С. 129214 - 129214
Опубликована: Март 2, 2023
The
COVID-19
pandemic
caused
by
the
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
continues
to
threaten
human
health
and
create
socioeconomic
problems
worldwide.
A
library
of
200,000
small
molecules
from
Korea
Chemical
Bank
(KCB)
were
evaluated
for
their
inhibitory
activities
against
SARS-CoV-2
in
a
phenotypic-based
screening
assay
discover
new
therapeutics
combat
COVID-19.
primary
hit
this
screen
was
quinolone
structure-containing
compound
1.
Based
on
structure
1
enoxacin,
which
is
quinolone-based
antibiotic
previously
reported
have
weak
activity
SARS-CoV-2,
we
designed
synthesized
2-aminoquinolone
acid
derivatives.
Among
them,
9b
exhibited
potent
antiviral
(EC
