Seoul orthohantavirus evades innate immune activation by reservoir endothelial cells DOI Creative Commons

Stefan D. Klimaj,

Autumn T. LaPointe,

Kimberly Martinez

и другие.

PLoS Pathogens, Год журнала: 2024, Номер 20(11), С. e1012728 - e1012728

Опубликована: Ноя. 25, 2024

Pathogenic hantaviruses are maintained world-wide within wild, asymptomatic rodent reservoir hosts, with increasingly frequent human spillover infections resulting in severe hemorrhagic fever or cardio-pulmonary disease. With no approved therapeutics vaccines, research has, until recently, focused on understanding the drivers of immune-mediated pathogenesis. An emerging body work is now investigating mechanisms that allow for asymptomatic, persistent mammalian hosts highly pathogenic RNA viruses. Despite limited experimental data, several hypotheses have arisen to explain absent disease pathology hosts. In this study, we directly tested two leading hypotheses: 1) host cells induce a generally muted response viral insults, and 2) these viruses employ host-specific innate antiviral antagonism limit immune activation cells. We demonstrate that, contrast endothelial which mount robust inflammatory hantaviruses, primary Norway rat do not gene expression infection their endemic hantavirus, Seoul orthohantavirus (SEOV). Reservoir do, however, strong responses exogenous stimulatory RNAs, type I interferon, Hantaan virus, closely related hantavirus natural reservoir. also find SEOV-infected remain competent induced by stimuli subsequent infection. Importantly, findings support an alternative model persistence hosts: efficient replication may prevent exposure critical motifs cellular recognition thus limits would otherwise result clearance and/or Defining tolerance will reveal novel strategies countermeasures against zoonotic threats.

Язык: Английский

Neurovirulent Pathogens Across the Human Lifespan: A Balancing Act DOI
Lisa N. Akhtar, Anita K. McElroy

Journal of the Pediatric Infectious Diseases Society, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Journal Article Corrected proof Neurovirulent Pathogens Across the Human Lifespan: A Balancing Act Get access Lisa N Akhtar, Akhtar Division of Infectious Diseases, Department Pediatrics, Ann and Robert H. Lurie Children's Hospital Chicago, Illinois, USADepartment Northwestern University Feinberg School Medicine, USA Corresponding Author: N. MD, PhD, 303 E. Superior Street, IL 60611, USA. E-mail: [email protected]. https://orcid.org/0000-0002-6560-4185 Search for other works by this author on: Oxford Academic PubMed Google Scholar Anita McElroy Pittsburgh Pittsburgh, Pennsylvania, USACenter Vaccine Research, Pediatric Diseases Society, piae118, https://doi.org/10.1093/jpids/piae118 Published: 08 January 2025 history Received: 21 November 2024 Editorial decision: 22 Accepted: 02 December typeset:

Язык: Английский

Процитировано

0
Neurovirulent Pathogens Across the Human Lifespan: A Balancing Act DOI Creative Commons
Lisa N. Akhtar, Anita K. McElroy

The Journal of Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Язык: Английский

Процитировано

0
The HAVCR1-centric host factor network drives Zika virus vertical transmission DOI Creative Commons
Wenzhe Yu,

Jun Tao,

Hongmin Cao

и другие.

Cell Reports, Год журнала: 2025, Номер 44(4), С. 115464 - 115464

Опубликована: Март 30, 2025

Язык: Английский

Процитировано

0
Global Burden and Incidence Trends of Zika Virus Infection among Women Aged 15-49 years from 2011 to 2021: A Systematic Analysis DOI Creative Commons
Chenyuan Qin, Yaping Wang, Min Liu

и другие.

Journal of Infection and Public Health, Год журнала: 2024, Номер 17(11), С. 102557 - 102557

Опубликована: Сен. 27, 2024

Язык: Английский

Процитировано

3
Seoul orthohantavirus evades innate immune activation in reservoir endothelial cells DOI Open Access

Stefan D. Klimaj,

Autumn T. LaPointe,

Kimberly Martinez

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 18, 2024

Abstract Pathogenic hantaviruses are maintained world-wide within wild, asymptomatic rodent reservoir hosts, with increasingly frequent human spillover infections resulting in severe hemorrhagic fever disease. With no approved therapeutics or vaccines, research has, until recently, focused on understanding the drivers of immune-mediated pathogenesis. An emerging body work is now investigating mechanisms that allow for asymptomatic, persistent mammalian hosts highly pathogenic RNA viruses. Despite limited experimental data, several hypotheses have arisen to explain absent disease pathology hosts. In this study, we directly tested two leading hypotheses: 1) host cells induce a generally muted response viral insults, and 2) these viruses employ host-specific innate antiviral antagonism limit immune activation cells. We demonstrate that, contrast endothelial which mount robust inflammatory hantaviruses, primary Norway rat do not gene expression infection their endemic hantavirus, Seoul orthohantavirus (SEOV). Reservoir do, however, strong responses exogenous stimulatory RNAs, type I interferon, Hantaan virus, closely related hantavirus natural reservoir. also find SEOV-infected remain competent induced by stimuli subsequent infection. Importantly, findings support an alternative model persistence hosts: efficient replication prevents exposure critical motifs cellular recognition thus limits would otherwise result clearance and/or Defining tolerance will reveal novel strategies countermeasures inform rational surveillance programs. Author Summary significant, continual, threat health, evidence explains underly zoonotic virus natural, Here, investigated whether target hypothesis through long-term co-evolution, actively antagonizes signaling pathways induction prevent While hypotheses, our may production immune-stimulating by-products. The factors determine reservoirs include use co-factors genome packaging warrant further investigation.

Язык: Английский

Процитировано

0
In Situ Analyses of Placental Inflammatory Response to SARS-CoV-2 Infection in Cases of Mother–Fetus Vertical Transmission DOI Open Access
Denise Morotti, Silvia Tabano, Gabriella Gaudioso

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 8825 - 8825

Опубликована: Авг. 13, 2024

It has been shown that vertical transmission of the SARS-CoV-2 strain is relatively rare, and there still limited information on specific impact maternal infection transmission. The current study focuses a transcriptomics analysis aimed at examining differences in gene expression between placentas from mother-newborn pairs affected by COVID-19 those unaffected controls. Additionally, it investigates situ molecules involved placental inflammation. Papa Giovanni XXIII Hospital Bergamo, Italy, recorded three instances intrauterine SARS-CoV-2. first two cases occurred early pandemic pregnant women their third trimester who were diagnosed with case an asymptomatic woman her second twin pregnancy, unfortunately delivered stillborn fetuses due to premature rupture membranes. Transcriptomic revealed significant placentae COVID-19-affected mother/newborn matched infected control for gestational age. According Benjamani-Hochberg method, 305 genes met criterion adjusted p-value less than 0.05, 219 0.01. Up-regulated cell signaling (e.g., CCL20, C3, MARCO) immune response LILRA3, CXCL10, CD48, CD86, IL1RN, IL-18R1) suggest potential role inflammatory RNAscope® technology, coupled image analysis, was utilized quantify surface area covered SARS-CoV-2, ACE2, IL-1β, IL-6, IL-8, IL-10, TNF-α both fetal sides placenta. A non-statistically gradient observed, higher coverage side (2.42 ± 3.71%) compared (0.74 1.19%) Although not statistically significant, ACE2 mRNA (0.02 0.04%) (0.01 0.01%) IL-6 IL-8 more prevalent (0.03 0.04% 0.06 0.08%, respectively) 0.01% 0.02 0.02%, respectively). mean areas IL-1β IL-10 found be equal (0.04 0.01 0.01%, placenta 0.05% 0.02% On side, ACE-2 all examined interleukins, but TNF-α, exhibited inverse amount ACE-2, inversely correlated (r = -0.3, r -0.1 -0.4, respectively), while showed positive correlations 0.9, p 0.005 0.5, correlation 0.4) 0.9) Further research needed evaluate Nonetheless, extends our comprehension molecular immunological factors underlying maternal-fetal

Язык: Английский

Процитировано

0
Sex, Gender, and Other Factors That Influence Infections for Men and Women DOI
Chandler Johnson, Amy Baldwin, Lia Pierson Bruner

и другие.

Infectious Diseases in Clinical Practice, Год журнала: 2024, Номер 32(5), С. 1405 - 1405

Опубликована: Сен. 1, 2024

Abstract In this review, the anatomical, physiological, immunological, societal, and behavioral differences that influence infections for men women will be reviewed followed by a discussion of in vaccine responses nature different organ systems. This is third series reviews examine infectious disease presentation demographics. Previously, were compared children older adults. previous are highly appropriate sharing with, educating colleagues, residents students.

Язык: Английский

Процитировано

0
Statistical Study on Maternal Immunological Adaptation During Normal Pregnancy DOI Open Access

Samar Kadhim Yousif

European Journal of Medical and Health Sciences, Год журнала: 2024, Номер 6(5), С. 41 - 44

Опубликована: Сен. 25, 2024

Background: The immune system of the mother’s body undergoes several modifications throughout pregnancy to protect baby from harm and prevent attacking it. In addition, physiological immunological changes that occur during increase risk severity some infections. Aim study: Provide comprehensive documentation adaptation in pregnant mothers variables associated with system. Methods: this study, 40 women between ages 15 43 participated. Abu Alkhaseeb General Hospital Basra City filed data March 2023 August 2023. gathered included age, number abortions, impact WBC levels pregnancy, frequent diseases pregnancy. Results Discussion: Urinary tract infection was found be most referral among women, constituting about 62% data, comparisons proportions were performed. A p-value below 0.05 considered statistically significant. results indicated white blood cells first, second, third trimesters does not differ significantly. highest cell count recorded trimester (10.34), while percentages for first second close at 9.935 9.510, respectively. Conclusion: There are no significant associations maternal trimester. women. 86% did miscarry.

Язык: Английский

Процитировано

0
Seoul orthohantavirus evades innate immune activation by reservoir endothelial cells DOI Creative Commons

Stefan D. Klimaj,

Autumn T. LaPointe,

Kimberly Martinez

и другие.

PLoS Pathogens, Год журнала: 2024, Номер 20(11), С. e1012728 - e1012728

Опубликована: Ноя. 25, 2024

Pathogenic hantaviruses are maintained world-wide within wild, asymptomatic rodent reservoir hosts, with increasingly frequent human spillover infections resulting in severe hemorrhagic fever or cardio-pulmonary disease. With no approved therapeutics vaccines, research has, until recently, focused on understanding the drivers of immune-mediated pathogenesis. An emerging body work is now investigating mechanisms that allow for asymptomatic, persistent mammalian hosts highly pathogenic RNA viruses. Despite limited experimental data, several hypotheses have arisen to explain absent disease pathology hosts. In this study, we directly tested two leading hypotheses: 1) host cells induce a generally muted response viral insults, and 2) these viruses employ host-specific innate antiviral antagonism limit immune activation cells. We demonstrate that, contrast endothelial which mount robust inflammatory hantaviruses, primary Norway rat do not gene expression infection their endemic hantavirus, Seoul orthohantavirus (SEOV). Reservoir do, however, strong responses exogenous stimulatory RNAs, type I interferon, Hantaan virus, closely related hantavirus natural reservoir. also find SEOV-infected remain competent induced by stimuli subsequent infection. Importantly, findings support an alternative model persistence hosts: efficient replication may prevent exposure critical motifs cellular recognition thus limits would otherwise result clearance and/or Defining tolerance will reveal novel strategies countermeasures against zoonotic threats.

Язык: Английский

Процитировано

0