Research Progress of FIBCD1 Mediated Host-Related Biological Functions by Recognizing Chitin
Journal of Clinical Personalized Medicine,
Год журнала:
2025,
Номер
04(02), С. 972 - 980
Опубликована: Янв. 1, 2025
Язык: Английский
Human immunity to fungal infections
The Journal of Experimental Medicine,
Год журнала:
2025,
Номер
222(6)
Опубликована: Апрель 15, 2025
Fungi
increasingly
threaten
health
globally.
Mycoses
range
from
life-threatening,
often
iatrogenic
conditions,
to
enigmatic
syndromes
occurring
without
apparent
immunosuppression.
Despite
some
recent
advances
in
antifungal
drug
development,
complementary
therapeutic
strategies
are
essential
for
addressing
these
opportunistic
pathogens.
One
promising
avenue
is
leveraging
host
immunity
combat
fungal
infections;
this
necessitates
deeper
understanding
of
the
molecular
immunology
human
susceptibility
differentiate
beneficial
versus
harmful
immunopathological
responses.
Investigating
models
diseases
natural
settings,
particularly
through
genetic
immunodeficiencies
and
ethnographic-specific
vulnerabilities,
reveals
crucial
immune
pathways
fighting
various
yeasts
molds.
This
review
highlights
diversity
intrinsic
across
individuals
populations,
genetic-
autoantibody-mediated
processes,
complementing
previous
principles
learned
animal
studies
contexts.
Improved
will
facilitate
development
host-directed
immunotherapies
targeted
public
interventions,
paving
way
precision
medicine
disease
management.
Язык: Английский
Full Circle: When HSFs bring the heat—mapping the transcriptional circuitries of HSF-type regulators in Candida albicans
mSphere,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
ABSTRACT
Heat
shock
factor
(HSF)-type
regulators
are
stress-responsive
transcription
factors
widely
distributed
among
eukaryotes,
including
fungi.
They
carry
a
four-stranded
winged
helix-turn-helix
DNA-binding
domain
considered
as
the
signature
for
HSFs.
The
genome
of
opportunistic
yeast
Candida
albicans
encodes
four
HSF
members,
namely,
Sfl1,
Sfl2,
Skn7,
and
essential
regulator,
Hsf1.
C.
HSFs
do
not
only
respond
to
heat
and/or
temperature
variation
but
also
CO
2
levels,
oxidative
stress,
quorum
sensing,
acting
this
way
central
decision
makers.
In
minireview,
I
follow
on
heels
my
mSphere
Influence
commentary
(2020)
provide
an
overview
repertoire
in
Saccharomyces
cerevisiae
describe
how
their
genetic
perturbation
,
coupled
with
genome-wide
expression
location
analyses,
allow
map
transcriptional
circuitry.
highlight
they
can
regulate,
common,
crucial
developmental
program:
filamentous
growth.
Язык: Английский
Efficacy of Limosilactobacillus fermentum in the management of vulvovaginal candidiasis: comparative analysis with topical miconazole in a single-blind randomized clinical trial
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 1, 2024
Vulvovaginal
candidiasis
(VVC)
significantly
impacts
women's
quality
of
life
and
often
shows
a
high
recurrence
rate
despite
conventional
antifungal
therapies.
This
study
evaluates
the
efficacy
Язык: Английский
An IL-17-DUOX2 axis controls gastrointestinal colonization byCandida albicans
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 19, 2024
Candida
albicans
is
a
ubiquitous
fungus
in
the
human
gut
microbiome
as
well
prevalent
cause
of
opportunistic
mucosal
and
systemic
disease.
There
currently
little
understanding,
however,
to
how
crosstalk
between
C.
host
regulates
colonization
this
key
niche.
Here,
we
performed
expression
profiling
on
ileal
colonic
tissues
germ-free
mice
colonized
with
define
global
response
fungus.
We
reveal
that
Duox2
Duoxa2
,
encoding
dual
NADPH
oxidase
activity,
are
upregulated
both
ileum
colon,
induction
requires
yeast-hyphal
transition
hyphal-specific
toxin
candidalysin.
Hosts
lacking
IL-17
receptor
failed
upregulate
Duox2/Duoxa2
while
addition
IL-17A
colonoids
induced
these
genes
together
concomitant
production
hydrogen
peroxide.
To
directly
role
fungal
colonization,
antibiotic-treated
intestinal
DUOX2
activity
were
evaluated
for
responses.
Surprisingly,
loss
function
reduced
at
extended
time
points
(>17
days
colonization)
increased
proportion
hyphal
cells
gut.
levels
also
elevated
-colonized
functional
highlighting
cross-regulation
cytokine
DUOX2.
Together,
experiments
novel
links
cells,
candidalysin
IL-17-DUOX2
axis,
complex
interplay
factors
filamentation
Язык: Английский