Principal Investigator Responsibility for Flagging Research with Dual-Use or Pandemic Risk DOI
Marc Lipsitch

Applied Biosafety, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

The new United States Government Policy for Oversight of Dual-Use Research Concern and Pathogens with Enhanced Pandemic Potential places primary responsibility on the proposing principal investigator to flag potential need special review. This approach may carry significant risks, given that investigators have incentives downplay types risks policy aims address, compounded by substantial opposition from many virologists. However, this commentary argues such an is much more consistent proven models research oversight protecting human subjects animals be essential in long run. It identifies several independent but potentially mutually reinforcing preconditions success — which will require creativity investment not fully specified regulations: researcher training dual-use population-level biosafety effective institutional-level support scrutiny evaluation, cultural change, checks balances, speedy evaluation low-risk research.

Язык: Английский

Ecological countermeasures to prevent pathogen spillover and subsequent pandemics DOI Creative Commons
Raina K. Plowright, Aliyu Nuhu Ahmed, Tim Coulson

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Март 26, 2024

Abstract Substantial global attention is focused on how to reduce the risk of future pandemics. Reducing this requires investment in prevention, preparedness, and response. Although preparedness response have received significant focus, especially prevention zoonotic spillover, remains largely absent from conversations. This oversight due part lack a clear definition guidance achieve it. To address gap, we elucidate mechanisms linking environmental change spillover using viruses bats as case study. We identify ecological interventions that can disrupt these propose policy frameworks for their implementation. Recognizing pandemics originate systems, advocate integrating approaches alongside biomedical comprehensive balanced pandemic strategy.

Язык: Английский

Процитировано

40

The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence DOI

James C. Alwine,

Felicia Goodrum, Bruce W. Banfield

и другие.

Journal of Virology, Год журнала: 2024, Номер 98(9)

Опубликована: Авг. 1, 2024

Science is humanity's best insurance against threats from nature, but it a fragile enterprise that must be nourished and protected. The preponderance of scientific evidence indicates natural origin for SARS-CoV-2. Yet, the theory SARS-CoV-2 was engineered in escaped lab dominates media attention, even absence strong evidence. We discuss how resulting anti-science movement puts research community, research, pandemic preparedness at risk.

Язык: Английский

Процитировано

7

Implementing governmental oversight of enhanced potential pandemic pathogen research DOI
Richard H. Ebright, C. Raina MacIntyre, Joseph P. Dudley

и другие.

Journal of Virology, Год журнала: 2024, Номер 98(4)

Опубликована: Март 17, 2024

Язык: Английский

Процитировано

2

Reply to Lipsitch et al., "Public role in research oversight" DOI
Angela L. Rasmussen, Gigi Kwik Grönvall, Anice C. Lowen

и другие.

Journal of Virology, Год журнала: 2024, Номер 98(4)

Опубликована: Март 17, 2024

Язык: Английский

Процитировано

1

Public role in research oversight DOI
Marc Lipsitch,

Thomas V. Inglesby,

Anita Cicero

и другие.

Journal of Virology, Год журнала: 2024, Номер 98(4)

Опубликована: Март 17, 2024

Язык: Английский

Процитировано

1

Reply to Ebright et al., “Implementing governmental oversight of enhanced potential pandemic pathogen research” DOI
Angela L. Rasmussen, Gigi Kwik Grönvall, Anice C. Lowen

и другие.

Journal of Virology, Год журнала: 2024, Номер 98(4)

Опубликована: Март 17, 2024

Язык: Английский

Процитировано

0

Reply to Masters: Recombinant coronavirus balances biosafety and benefit DOI Creative Commons
Jonathan W. Yewdell

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(44)

Опубликована: Окт. 21, 2024

Язык: Английский

Процитировано

0

Principal Investigator Responsibility for Flagging Research with Dual-Use or Pandemic Risk DOI
Marc Lipsitch

Applied Biosafety, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

The new United States Government Policy for Oversight of Dual-Use Research Concern and Pathogens with Enhanced Pandemic Potential places primary responsibility on the proposing principal investigator to flag potential need special review. This approach may carry significant risks, given that investigators have incentives downplay types risks policy aims address, compounded by substantial opposition from many virologists. However, this commentary argues such an is much more consistent proven models research oversight protecting human subjects animals be essential in long run. It identifies several independent but potentially mutually reinforcing preconditions success — which will require creativity investment not fully specified regulations: researcher training dual-use population-level biosafety effective institutional-level support scrutiny evaluation, cultural change, checks balances, speedy evaluation low-risk research.

Язык: Английский

Процитировано

0