Major New Microbial Groups Expand Diversity and Alter our Understanding of the Tree of Life

Cell, Год журнала: 2018, Номер 172(6), С. 1181 - 1197

Опубликована: Март 1, 2018

Язык: Английский

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Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

npj Parkinson s Disease, Год журнала: 2021, Номер 7(1)

Опубликована: Март 10, 2021

The gut microbiota is emerging as an important modulator of neurodegenerative diseases, and accumulating evidence has linked microbes to Parkinson's disease (PD) symptomatology pathophysiology. PD often preceded by gastrointestinal symptoms alterations the enteric nervous system accompany disease. Several studies have analyzed microbiome in PD, but a consensus on features PD-specific missing. Here, we conduct meta-analysis re-analyzing ten currently available 16S datasets investigate whether common patients exist across cohorts. We found significant PD-associated microbiome, which are robust study-specific technical heterogeneities, although differences structure between controls small. Enrichment genera Lactobacillus, Akkermansia, Bifidobacterium depletion bacteria belonging Lachnospiraceae family Faecalibacterium genus, both short-chain fatty acids producers, emerged most consistent alterations. This dysbiosis might result pro-inflammatory status could be recurrent affecting patients.

Язык: Английский

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The Role of Lung and Gut Microbiota in the Pathology of Asthma

Immunity, Год журнала: 2020, Номер 52(2), С. 241 - 255

Опубликована: Фев. 1, 2020

Язык: Английский

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The microbiome of the upper respiratory tract in health and disease

BMC Biology, Год журнала: 2019, Номер 17(1)

Опубликована: Ноя. 7, 2019

Abstract The human upper respiratory tract (URT) offers a variety of niches for microbial colonization. Local communities are shaped by the different characteristics specific location within URT, but also interaction with both external and intrinsic factors, such as ageing, diseases, immune responses, olfactory function, lifestyle habits smoking. We summarize here current knowledge about URT microbiome in health disease, discuss methodological issues, consider potential nasal to be used medical diagnostics target therapy.

Язык: Английский

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Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations

Nature Reviews Microbiology, Год журнала: 2018, Номер 16(10), С. 629 - 645

Опубликована: Сен. 4, 2018

Язык: Английский

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Methanogenesis

Current Biology, Год журнала: 2018, Номер 28(13), С. R727 - R732

Опубликована: Июль 1, 2018

Язык: Английский

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The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release

Frontiers in Physiology, Год журнала: 2019, Номер 10

Опубликована: Апрель 16, 2019

The microbial community of the gut conveys significant benefits to host physiology. A clear relationship has now been established between bacteria and metabolism in which microbial-mediated hormone release plays an important role. Within lumen, produce a number metabolites contain structural components that act as signaling molecules cell types within mucosa. Enteroendocrine cells mucosal lining synthesize secrete hormones including CCK, PYY, GLP-1, GIP 5-HT, have regulatory roles key metabolic processes such insulin sensitivity, glucose tolerance, fat storage appetite. Release these can be influenced by presence their such, is component regulation metabolism. Dietary or pharmacological interventions alter microbiome therefore pose potential therapeutics for treatment human disorders. This review aims describe complex interaction intestinal microbiota enteroendocrine cells, highlight how influence through release.

Язык: Английский

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Multi-kingdom ecological drivers of microbiota assembly in preterm infants

Nature, Год журнала: 2021, Номер 591(7851), С. 633 - 638

Опубликована: Фев. 24, 2021

Язык: Английский

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Ammonia oxidation: Ecology, physiology, biochemistry and why they must all come together

FEMS Microbiology Letters, Год журнала: 2018, Номер 365(9)

Опубликована: Март 9, 2018

Ammonia oxidation is a fundamental core process in the global biogeochemical nitrogen cycle. Oxidation of ammonia (NH3) to nitrite (NO2 -) first and rate-limiting step nitrification carried out by distinct groups microorganisms. essential for nutrient turnover most terrestrial, aquatic engineered ecosystems plays major role, both directly indirectly, greenhouse gas production environmental damage. Although has been studied over century, this research field galvanised past decade surprising discoveries novel oxidising This review reflects on date discusses gaps remaining our knowledge biology oxidation.

Язык: Английский

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Metaorganisms in extreme environments: do microbes play a role in organismal adaptation?

Zoology, Год журнала: 2018, Номер 127, С. 1 - 19

Опубликована: Фев. 15, 2018

From protists to humans, all animals and plants are inhabited by microbial organisms. There is an increasing appreciation that these resident microbes influence the fitness of their plant animal hosts, ultimately forming a metaorganism consisting uni- or multicellular host community associated microorganisms. Research on host–microbe interactions has become emerging cross-disciplinary field. In both vertebrates invertebrates complex microbiome confers immunological, metabolic behavioural benefits; conversely, its disturbance can contribute development disease states. However, molecular cellular mechanisms controlling within poorly understood many key between organisms remain unknown. this perspective article, we outline some issues in interspecies particular address question how metaorganisms react adapt inputs from extreme environments such as deserts, intertidal zone, oligothrophic seas, hydrothermal vents.

Язык: Английский

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