Antibiotic resistance is a growing threat — is climate change making it worse?

Nature, Год журнала: 2024, Номер unknown

Опубликована: Янв. 8, 2024

Язык: Английский

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Control of Vibrio vulnificus proliferation in the Baltic Sea through eutrophication and algal bloom management

Communications Earth & Environment, Год журнала: 2024, Номер 5(1)

Опубликована: Май 9, 2024

Abstract Due to climate change the pathogenic bacterium Vibrio vulnificus proliferates along brackish coastlines, posing risks public health, tourism, and aquaculture. Here we investigated previously suggested regulation measures reduce prevalence of V. , locally through seagrass regionally reduction eutrophication consequential formation algal blooms. Field samples collected in summer 2021 covered salinity gradients Baltic Sea, one largest areas worldwide. Physico-, biological- hydrochemical parameters were measured variables explaining occurrence identified by machine learning. The best predictors eutrophication-related features, such as particulate organic carbon nitrogen, well potential phytoplankton blooms associated species . abundance did not vary significantly between vegetated non-vegetated areas. Thus, reducing nutrient inputs could be an effective method control populations eutrophied coasts.

Язык: Английский

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Public health aspects of Vibrio spp. related to the consumption of seafood in the EU

EFSA Journal, Год журнала: 2024, Номер 22(7)

Опубликована: Июль 1, 2024

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Antibiotic Resistance in Vibrio parahaemolyticus: Mechanisms, Dissemination, and Global Public Health Challenges—A Comprehensive Review

Reviews in Aquaculture, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 1, 2025

ABSTRACT Vibrio parahaemolyticus , a ubiquitous pathogen in marine and estuarine environments, is foodborne microorganism whose infections have become global public health challenge. In recent years, the overuse misuse of antibiotics led to emergence increasing numbers antibiotic‐resistant strains V. worldwide. These harbor resistance genes that mediate various mechanisms, presenting significant challenge antibiotic therapy. Furthermore, horizontal gene transfer (HGT) accelerating impacts climate change facilitated formation spread resistance, contributing proliferation resistant exacerbating threat. This review aims provide comprehensive overview mechanisms effects on its strategies curb transmission strains. Additionally, we conducted statistical analysis data from 6727 isolates obtained 27 countries across Asia, Africa, Americas, Europe, through literature review, better understand distribution trends this pathogen. We hope study will serve as an important reference for controlling addressing critical issue.

Язык: Английский

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Machine Learning Potential for Identifying and Forecasting Complex Environmental Drivers of Vibrio vulnificus Infections in the United States

Environmental Health Perspectives, Год журнала: 2025, Номер 133(1)

Опубликована: Янв. 1, 2025

Environmental change in coastal areas can drive marine bacteria and resulting infections, such as those caused by Vibrio vulnificus, with both foodborne nonfoodborne exposure routes high mortality. Although ecological drivers of V. vulnificus the environment have been well-characterized, fewer models able to apply this human infection risk due limited surveillance. The Cholera Other Illness Surveillance (COVIS) system database has reported infections United States since 1988, offering a unique opportunity explore forecasting capabilities machine learning could provide characterize complex environmental infections. Machine models, form random forest classification were trained refined using epidemiological data from 2008 2018, six variables (sea surface temperature, salinity, chlorophyll concentration, sea level, land runoff rate) categorical encoders assess our predictive potential forecast based on data. highest-performing model, which used balanced classes, had an Area Under Curve score 0.984 sensitivity 0.971, highlighting anticipate periods risk. A higher false positive rate was found when model applied real-world imbalanced surveillance data, is pertinent amid modeled underreporting misdiagnosis ratios Further also developed multilevel spatial resolution, finding state-specific improve specificity early warning exclusively lagged approach nonlinear interacting associations driving This study accentuates robust for environmentally associated providing future directions improvements, further application, operationalization. https://doi.org/10.1289/EHP15593.

Язык: Английский

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Unseen Drivers of Antimicrobial Resistance: The Role of Industrial Agriculture and Climate Change in This Global Health Crisis

Challenges, Год журнала: 2025, Номер 16(2), С. 22 - 22

Опубликована: Апрель 21, 2025

Antimicrobial resistance (AMR) is an urgent global health threat with many anthropogenic drivers outside of healthcare. The impacts modern agriculture on human are manifold, from the food systems and dietary patterns they support to less apparent effects environmental stresses biodiversity loss in ecosystems. Intensive practices, such as chemical fertilizers, pesticides, herbicides, induce abiotic that deplete drive AMR soil aquatic microbiomes. overuse antibiotics livestock production another major driver AMR. Changes weather due climate change have potential exacerbate these issues warmer wetter increases for bacterial infection. While practices exist address healthcare-associated drivers, impact destruction not widely appreciated healthcare biomedical sciences. It imperative professionals public experts understand connections properly emergent issue This review aims summarize current data important agricultural educational purposes, fill gaps knowledge, improve stimulate further research.

Язык: Английский

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Detection of Hepatitis E Virus in Game Meat (Wild Boar) Supply Chain in Umbria Region, Central Italy

Foods, Год журнала: 2024, Номер 13(16), С. 2504 - 2504

Опубликована: Авг. 9, 2024

Consumption of raw or undercooked wild boar (WB) meat is considered an important risk factor for hepatitis E virus (HEV) infection in humans. The possibility HEV contamination during the slaughtering practices may pose additional risk. Based on these assumptions, we evaluated WB hunted Umbria (central Italy) 2022–2023 hunting season by real-time RT-PCR. Herein, show that 10.8% livers from slaughtered were positive RNA, thus providing estimate region. Then, evaluating paired liver–muscle samples both HEV-positive and HEV-negative animals, found evidence muscle 33% 14% cases, respectively. This first report detection Umbria, Italian region with diffuse consumption. provided our study underscores importance adopting good hygienic processing stages carcasses to significantly reduce posed final consumer.

Язык: Английский

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Climate change and Vibrio vulnificus dynamics: A blueprint for infectious diseases

PLoS Pathogens, Год журнала: 2024, Номер 20(12), С. e1012767 - e1012767

Опубликована: Дек. 16, 2024

Climate change is having increasingly profound effects on human health, notably those associated with the occurrence, distribution, and transmission of infectious diseases. The number disparate ecological parameters pathogens affected by climate are vast expansive. Disentangling complex relationship between these variables critical for development effective countermeasures against its effects. pathogen Vibrio vulnificus , a naturally occurring aquatic bacterium that causes fulminant septicemia, represents quintessential climate-sensitive organism. In this review, we use V . as model organism to elucidate intricate network interactions climatic factors pathogens, objective identifying common patterns which affecting their disease burden. Recent findings indicate in regions native or related climate-driven natural disasters chief contributors outbreaks. Concurrently, increasing environmental suitability areas non-endemic diseases, promoting surge populations dynamics, thus elevating risk new We highlight potential drivers aggravating threat under both scenarios propose measures mitigating impact. By defining mechanisms influences burden, aim shed light dynamics disease-causing agents, thereby laying groundwork early warning systems broadly applicable control measures.

Язык: Английский

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One Health, climate change, and infectious microbes: a joint effort between AGU and ASM to understand impacts of changing climate and microbes on human well-being across scales

mSphere, Год журнала: 2024, Номер 9(2)

Опубликована: Янв. 31, 2024

Язык: Английский

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Wildfire Ashes from the Wildland-Urban Interface Alter Vibrio vulnificus Growth and Gene Expression

Environmental Science & Technology, Год журнала: 2024, Номер 58(19), С. 8169 - 8181

Опубликована: Май 1, 2024

Climate change-induced stressors are contributing to the emergence of infectious diseases, including those caused by marine bacterial pathogens such as Vibrio spp. These alter temporal and geographical distribution, resulting in increased spread, exposure, infection rates, thus facilitating greater Vibrio−human interactions. Concurrently, wildfires increasing size, severity, frequency, spread built environment due climate change, emission contaminants emerging concern. This study aimed understand potential effects urban interface wildfire ashes on vulnificus (V. vulnificus) growth gene expression using transcriptomic approaches. V. was exposed structural vegetation analyzed identify differentially expressed genes HTSeq-DESeq2 strategy. Exposure ash altered expression, depending trace metal composition ash. The high Fe content enhanced growth, while Cu, As, Cr suppressed growth. Additionally, overall pattern upregulated pathways suggests virulence selection metal- antibiotic-resistant strains. Therefore, mixed fire transported deposited into coastal zones may lead environmental reservoirs strains with antibiotic resistance profiles, public health risk.

Язык: Английский

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