Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Фев. 11, 2025

The oral microbiome comprises over 700 distinct species, forming complex biofilms essential for maintaining and systemic health. When the microbial homeostasis in periodontium is disrupted, pathogens within biofilm can cause periodontitis peri-implantitis, inducing host immune responses. Understanding role of communities mechanisms health disease crucial developing improved preventive, diagnostic therapeutic strategies. However, many questions remain about how changes bacterial populations contribute to development progression these conditions. An electronic manual literature search was conducted using PubMed, Excerpta Medica, Frontiers Reports Wiley Online Library databases relevant articles. Data from publications were extracted overall findings summarized a narrative manner. variations responses peri-implantitis are explored. Dysbiosis subgingival microbiome—characterized by an increase pathogenic bacteria such as Porphyromonas gingivalis , Tannerella forsythia Aggregatibacter actinomycetemcomitans —plays pivotal initiation periodontitis. As alterations include higher abundance opportunistic reduced diversity around implants. Moreover, dysbiosis potentially influencing through immune-mediated pathways. Regional immunity involving neutrophils, T helper cells-17, immune-related cytokines periodontal responding imbalances. Additionally, impact non-mechanical treatments—such probiotics laser therapy—on discussed, demonstrating their potential managing dysbiosis. These underscore that central factor peri-implantitis. Maintaining balance preventing diseases, interventions targeting could enhance treatment outcomes. Strategies focusing on controlling bacteria, modulating responses, promoting tissue regeneration key restoring stability. Further research needed clarify underlying transition peri-implant mucositis optimize prevention approaches, considering interactions between immunity.

Язык: Английский

Recent advances in therapeutic probiotics: insights from human trials

Clinical Microbiology Reviews, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

SUMMARY Recent advances in therapeutic probiotics have shown promising results across various health conditions, reflecting a growing understanding of the human microbiome’s role and disease. However, comprehensive reviews integrating diverse effects subjects been limited. By analyzing randomized controlled trials (RCTs) meta-analyses, this review provides overview key developments probiotic interventions targeting gut, liver, skin, vaginal, mental, oral health. Emerging evidence supports efficacy specific strains combinations treating wide range disorders, from gastrointestinal (GI) liver diseases to dermatological bacterial vaginosis, mental diseases. We discuss expanding microbiome-organ connections underlying mechanisms action. While many clinical demonstrate significant benefits, we acknowledge areas requiring further large-scale studies establish definitive optimal treatment protocols. The addresses challenges standardizing research methodologies emphasizes importance considering individual variations microbiome composition host genetics. Additionally, explore emerging concepts such as oral-gut-brain axis future directions, including high-resolution profiling, host-microbe interaction studies, organoid models, artificial intelligence applications research. Overall, offers update on current state multiple domains health, providing insights into directions potential for revolutionize preventive medicine.

Язык: Английский

Taxa de sucesso de dois diferentes implantes Cone Morse em região anterior superior; análise acompanhamento observacional, clínico e ultraestrutural, por até 10 anos

DELOS Desarrollo Local Sostenible, Год журнала: 2024, Номер 17(62), С. e3139 - e3139

Опубликована: Дек. 10, 2024

A procura por qualidade de vida não está somente relacionada a uma boa alimentação, prática regular esportes ou boas noites sono. saúde bucal é considerada porta entrada para o sucesso longo prazo. O presente estudo teve como objetivo realizar análise comparativa sobre taxa sobrevivência implantes cone Morse (Systhex®, 3.5/13mm, torque > 45 e < 60 Ncm, Avannt® Atractt® Curitiba, Brasil) em maxila anterior superior, sem carga imediata. Foram incluídos pacientes do sexo masculino feminino, com idades entre 28 65 anos, doenças pré-existentes, fumantes alcoólatras, sendo período reabertura 90 dias. analisados 413 implantes, meio radiografias periapicais, sondagem clínica tomografia computadorizada, durante um acompanhamento até 10 anos. Implantes mais 3mm perda óssea relação à crista mesial distal foram considerados perdidos além no momento da eventos adversos. Como resultados, obtivemos 97,65% nos anos 98% 6 demonstrando 99,9% certeza que há diferença estatística significativa os dois grupos. região anatômica afetada foi canino superior direita. conclusão podemos afirmar dos Atractt mesmo pouco menor ao tempo estatisticamente relevante quando comparados Avantt® ambos indicados utilização atingindo semelhante encontrada na literatura atual.