Microbiology and Molecular Biology Reviews, Год журнала: 2024, Номер 88(3)

Опубликована: Авг. 19, 2024

SUMMARY Understanding the dynamic adaptive plasticity of microorganisms has been advanced by studying their responses to extreme environments. Spaceflight research platforms provide a unique opportunity study microbial characteristics in new adaptational modes, including sustained exposure reduced forces gravity and associated low fluid shear force conditions. Under these conditions, unexpected occur, alterations virulence, antibiotic stress resistance, biofilm formation, metabolism, motility, gene expression, which are not observed using conventional experimental approaches. Here, we review biological physical mechanisms that regulate spaceflight analog environments from both microbe host-microbe perspective relevant human health habitat sustainability. We highlight instrumentation technology used microbiology experiments, limitations, advances necessary enable next-generation research. As experiments relatively rare, discuss ground-based analogs mimic aspects spaceflight, those reduce mechanical flow over cell surfaces also simulate conditions encountered during terrestrial lifecycles. mission durations increase with traditional astronauts commercial space programs send civilian crews underlying will continue play increasingly critical roles sustainability, thus defining dimension occupational health. The ability adapt, survive, evolve environment is important for future endeavors provides opportunities innovative technological benefit life on Earth.

Язык: Английский