SARS-CoV2 variants differentially impact on the plasma metabolome
Metabolomics,
Год журнала:
2025,
Номер
21(2)
Опубликована: Апрель 5, 2025
Abstract
Introduction
Infection
with
severe
acute
respiratory
syndrome-coronavirus-2
(SARS-CoV-2)
leads
to
COVID19
disease
and
caused
a
worldwide
pandemic
in
2019.
Since
the
first
wave
of
infections,
there
has
been
significant
antigenic
shifts,
leading
emergence
new
variants.
Today,
infections
have
shifted
away
from
severe,
fatal
infection
seen
Objective
This
study
aimed
assess
how
plasma
metabolomes
patients
varied
different
strains
could
reflect
severity.
Methods
Patients
not
requiring
intensive
care
were
recruited
between
January
2021
May
2022
Queen
Elizabeth
Hospital
Birmingham;
33
alpha,
13
delta
14
omicron
These
compared
26
age
matched
contemporaneously
controls.
Plasma
samples
extracted
into
chloroform/methanol/water
(1:2.5/1
v/v)
assessed
by
flow
injection
electrospray
mass
spectrometry
(FIE-MS)
using
an
Exactive
Orbitrap
spectrometer.
Derived
data
R
based
MetaboAnalyst
platform.
Results
clearly
Metabolite
variation
be
related
SARS-CoV2
Variant
showed
levels
some
phospholipids,
ganglioside
GD1a
dihydroxyvitamin
D3
derivative.
Correlations
indicated
negative
correlations
selected
phospholipids
C-reactive
protein,
creatinine,
neutrophil
D-dimer.
Conclusion
The
show
changes,
particularly
which
severity
variant
infection.
Язык: Английский
Metabolic effects of high-dose glucocorticoid following out-of-hospital cardiac arrest
Intensive Care Medicine Experimental,
Год журнала:
2025,
Номер
13(1)
Опубликована: Апрель 26, 2025
Язык: Английский
Host metabolomic responses in recurrent P. vivax malaria
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Март 27, 2024
Abstract
Malaria
is
the
leading
parasitic
disease
worldwide,
with
P.
vivax
being
a
major
challenge
for
its
control.
Several
studies
have
indicated
metabolomics
as
promising
tool
combating
disease.
The
study
evaluated
plasma
metabolomic
profiles
of
patients
recurrent
and
non-recurrent
malaria
in
Brazilian
Amazon.
Metabolites
extracted
from
-infected
were
subjected
to
LC–MS
analysis.
Untargeted
was
applied
investigate
metabolic
profile
two
groups.
Overall,
51
59
included
study.
Longitudinal
analysis
revealed
52
37
significant
metabolite
features
participants,
respectively.
Recurrence
associated
disturbances
eicosanoid
metabolism.
Comparison
between
groups
suggest
alterations
vitamin
B6
(pyridoxine)
metabolism,
tyrosine
3-oxo-10-octadecatrienoate
β-oxidation,
alkaloid
biosynthesis
II.
Integrative
network
enrichment
other
pathways
phenotype,
including
butanoate
aspartate
asparagine
N-glycan
biosynthesis.
metabolites
predicted
our
potential
biomarkers
recurrence
provide
insights
into
targets
antimalarial
development
against
.
Язык: Английский