Multi‐omics approach in gut and environmental microbiota research under the One Health concept DOI Creative Commons
Anna Kostka, Agnieszka Gruszecka‐Kosowska, Alicia Ruiz‐Rodríguez

и другие.

EFSA Journal, Год журнала: 2024, Номер 22

Опубликована: Дек. 1, 2024

Abstract The One Health concept, although formulated two decades ago, remains challenging to implement. It necessitates the integration of numerous scientific disciplines, diverse techniques and various professional expertise. Furthermore, it often requires collaboration different institutions, encompassing both administrative entities. This concept posits that human health is intrinsically linked dependent on well‐being animals, plants broader environment, while environment not only sustains life but can also serve as a source xenobiotics affect health‐disease balance. In this context, all components potential exposome, entirety factors natures influence throughout life, must be considered comprehensively. Achieving holistic understanding typically demands application multiple research techniques, known multi‐omics approach adoption an integrated method for data analysis. project endeavoured utilise such approach, examining from origins: (children stool gut microbiota analysis) environmental (groundwater hyporheic zone microbial analysis), well implementing comprehensive informatic tools processing. Analysis samples revealed significant differences in composition across taxonomic levels between normal weight, overweight obese children. Additionally, link certain composition, body weight overall status was identified. groundwater at based sampling location depth. Key geochemical influencing sample diversity were promising results obtained demonstrate viability methodology pave way future initiatives.

Язык: Английский

Impact of Ex Vivo Bisphenol A Exposure on Gut Microbiota Dysbiosis and Its Association with Childhood Obesity DOI Creative Commons
Gracia Luque, Pilar Ortíz, Alfonso Torres-Sánchez

и другие.

Journal of Xenobiotics, Год журнала: 2025, Номер 15(1), С. 14 - 14

Опубликована: Янв. 17, 2025

Dietary exposure to the plasticiser bisphenol A (BPA), an obesogenic and endocrine disruptor from plastic epoxy resin industries, remains prevalent despite regulatory restriction food safety efforts. BPA can be accumulated in humans animals, potentially exerting differential health effects based on individual metabolic capacity. This pilot study examines impact of direct ex vivo gut microbiota obese normal-weight children, using 16S rRNA amplicon sequencing anaerobic culturing combined methods. Results showed that xenobiotic induced modifications microbial taxa relative abundance, community structure, diversity. Specifically, reduced abundance bacteria belonging phylum Bacteroidota, while Actinomycetota were promoted. Consistently, Bacteroides species classified as sensitive BPA, whereas class Clostridia identified resistant our culturomics analysis. Some altered bacterial patterns common for both BPA-exposed groups non-exposed group study. These findings also corroborated a larger cohort children. Future research will essential evaluate these potential biomarkers biomonitoring effect its role substance

Язык: Английский

Процитировано

1
Sexual dimorphism in neurobehavioural phenotype and gut microbial composition upon long-term exposure to structural analogues of bisphenol-A DOI
Dhirendra Singh, Ashish Kumar, Jignesh Prajapati

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 476, С. 135178 - 135178

Опубликована: Июль 11, 2024

Язык: Английский

Процитировано

3
Perinatal bisphenol A exposure impairs gut microbial colonization: Implications for offspring obesity and neurodevelopment DOI
Ana López‐Moreno, Alfonso Torres-Sánchez, Antonio Suárez

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 298, С. 118295 - 118295

Опубликована: Май 10, 2025

Язык: Английский

Процитировано

0
Analysis of Human Gut Microbiota Enzymes for Biotechnological and Food Industrial Applications DOI Creative Commons
Alfonso Torres-Sánchez, Gracia Luque, Pilar Ortíz

и другие.

Foods, Год журнала: 2025, Номер 14(10), С. 1794 - 1794

Опубликована: Май 18, 2025

The human gut microbiota is a complex and dynamic ecosystem, recognized for its valuable wide array of physiological functions. This study investigated the as source enzymes innovative applications in biomedicine, bioremediation, food feed biotechnological industries by integrating data from combined silico vitro approaches. A total 93 easily cultivable strains were selected bank isolated microorganisms generated children under different media conditions. First, genomic screening enzyme interrogation reference genomes corresponding to species carried out using custom bioinformatic searching protocol. extraction interpretation encoding taxa results focused on four major phyla (Bacillota, Bacteroidota, Actinomycetota, Pseudomonadota) seven genera (Bacillus, Bacteroides, Clostridium, Enterobacter, Enterococcus, Microbacterium, Staphylococcus) according their cultivability relevance interest. 364 identified across protein annotations, highlighting amylases, cellulases, inulinases, lipases, proteases, laccases. Second, phenotypic assays confirmed these main enzymatic activities 80.6% isolates. Notable findings included Bacillus displaying relevant amylase laccase activity. demonstrates utility combining annotations with functional assays, offering robust approach exploiting develop sustainable processes. Moreover, regulatory mechanisms governing expression resilient microbes are essential steps toward unlocking full potential microbiota-derived biocatalysts.

Язык: Английский

Процитировано

0
Ultra-Processed Food Consumption as a Risk Factor for Gastrointestinal Cancer and Other Causes of Mortality in Southern Italy: A Competing Risk Approach DOI Open Access
Angelo Campanella, Rossella Tatoli, Caterina Bonfiglio

и другие.

Nutrients, Год журнала: 2024, Номер 16(13), С. 1994 - 1994

Опубликована: Июнь 23, 2024

Background: Ultra-Processed Foods (UPFs) are increasingly consumed worldwide, even in regions with strong dietary traditions like the Mediterranean and can play a crucial role development of chronic diseases, including cancer. This population-based prospective cohort study investigates association between UPF consumption gastrointestinal cancers other causes mortality Southern Italy. Methods: Data were collected from 4870 participants MICOL NUTRIHEP cohorts. The EPIC questionnaire was used to elicit information on food drink UPFs categorized by degree processing according NOVA classification. Cox proportional hazards regression competing risk models employed for statistical analysis. Results: positively associated all-cause mortality: 3rd UFP quartile, as compared lowest, had 27% higher death (SHR 1.27 95% CI, 1.03; 1.57), while highest quartile 34% 1.34 1.00; 1.79). Higher intake also correlated an increased risk, especially 2nd 1.65, CI: 1.01; 2.71) 4th 3.14 1.56; 6.32), dose-dependent effect. For cancers, SHR 1.61 (95% CI 2.54) observed quartile. Conclusions: Our results reinforce link cancer emphasizing urgent need interventions targeting patterns.

Язык: Английский

Процитировано

2
Real-world bisphenol A exposure not linked to microbiota dynamics in childhood obesity DOI Creative Commons

Robyn L. Prueitt,

Julie E. Goodman

mSystems, Год журнала: 2024, Номер 9(7)

Опубликована: Июль 3, 2024

Язык: Английский

Процитировано

1
Multi‐omics approach in gut and environmental microbiota research under the One Health concept DOI Creative Commons
Anna Kostka, Agnieszka Gruszecka‐Kosowska, Alicia Ruiz‐Rodríguez

и другие.

EFSA Journal, Год журнала: 2024, Номер 22

Опубликована: Дек. 1, 2024

Abstract The One Health concept, although formulated two decades ago, remains challenging to implement. It necessitates the integration of numerous scientific disciplines, diverse techniques and various professional expertise. Furthermore, it often requires collaboration different institutions, encompassing both administrative entities. This concept posits that human health is intrinsically linked dependent on well‐being animals, plants broader environment, while environment not only sustains life but can also serve as a source xenobiotics affect health‐disease balance. In this context, all components potential exposome, entirety factors natures influence throughout life, must be considered comprehensively. Achieving holistic understanding typically demands application multiple research techniques, known multi‐omics approach adoption an integrated method for data analysis. project endeavoured utilise such approach, examining from origins: (children stool gut microbiota analysis) environmental (groundwater hyporheic zone microbial analysis), well implementing comprehensive informatic tools processing. Analysis samples revealed significant differences in composition across taxonomic levels between normal weight, overweight obese children. Additionally, link certain composition, body weight overall status was identified. groundwater at based sampling location depth. Key geochemical influencing sample diversity were promising results obtained demonstrate viability methodology pave way future initiatives.

Язык: Английский

Процитировано

0