Impact of Ex Vivo Bisphenol A Exposure on Gut Microbiota Dysbiosis and Its Association with Childhood Obesity
Journal of Xenobiotics,
Год журнала:
2025,
Номер
15(1), С. 14 - 14
Опубликована: Янв. 17, 2025
Dietary
exposure
to
the
plasticiser
bisphenol
A
(BPA),
an
obesogenic
and
endocrine
disruptor
from
plastic
epoxy
resin
industries,
remains
prevalent
despite
regulatory
restriction
food
safety
efforts.
BPA
can
be
accumulated
in
humans
animals,
potentially
exerting
differential
health
effects
based
on
individual
metabolic
capacity.
This
pilot
study
examines
impact
of
direct
ex
vivo
gut
microbiota
obese
normal-weight
children,
using
16S
rRNA
amplicon
sequencing
anaerobic
culturing
combined
methods.
Results
showed
that
xenobiotic
induced
modifications
microbial
taxa
relative
abundance,
community
structure,
diversity.
Specifically,
reduced
abundance
bacteria
belonging
phylum
Bacteroidota,
while
Actinomycetota
were
promoted.
Consistently,
Bacteroides
species
classified
as
sensitive
BPA,
whereas
class
Clostridia
identified
resistant
our
culturomics
analysis.
Some
altered
bacterial
patterns
common
for
both
BPA-exposed
groups
non-exposed
group
study.
These
findings
also
corroborated
a
larger
cohort
children.
Future
research
will
essential
evaluate
these
potential
biomarkers
biomonitoring
effect
its
role
substance
Язык: Английский
Sexual dimorphism in neurobehavioural phenotype and gut microbial composition upon long-term exposure to structural analogues of bisphenol-A
Journal of Hazardous Materials,
Год журнала:
2024,
Номер
476, С. 135178 - 135178
Опубликована: Июль 11, 2024
Язык: Английский
Perinatal bisphenol A exposure impairs gut microbial colonization: Implications for offspring obesity and neurodevelopment
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
298, С. 118295 - 118295
Опубликована: Май 10, 2025
Язык: Английский
Analysis of Human Gut Microbiota Enzymes for Biotechnological and Food Industrial Applications
Foods,
Год журнала:
2025,
Номер
14(10), С. 1794 - 1794
Опубликована: Май 18, 2025
The
human
gut
microbiota
is
a
complex
and
dynamic
ecosystem,
recognized
for
its
valuable
wide
array
of
physiological
functions.
This
study
investigated
the
as
source
enzymes
innovative
applications
in
biomedicine,
bioremediation,
food
feed
biotechnological
industries
by
integrating
data
from
combined
silico
vitro
approaches.
A
total
93
easily
cultivable
strains
were
selected
bank
isolated
microorganisms
generated
children
under
different
media
conditions.
First,
genomic
screening
enzyme
interrogation
reference
genomes
corresponding
to
species
carried
out
using
custom
bioinformatic
searching
protocol.
extraction
interpretation
encoding
taxa
results
focused
on
four
major
phyla
(Bacillota,
Bacteroidota,
Actinomycetota,
Pseudomonadota)
seven
genera
(Bacillus,
Bacteroides,
Clostridium,
Enterobacter,
Enterococcus,
Microbacterium,
Staphylococcus)
according
their
cultivability
relevance
interest.
364
identified
across
protein
annotations,
highlighting
amylases,
cellulases,
inulinases,
lipases,
proteases,
laccases.
Second,
phenotypic
assays
confirmed
these
main
enzymatic
activities
80.6%
isolates.
Notable
findings
included
Bacillus
displaying
relevant
amylase
laccase
activity.
demonstrates
utility
combining
annotations
with
functional
assays,
offering
robust
approach
exploiting
develop
sustainable
processes.
Moreover,
regulatory
mechanisms
governing
expression
resilient
microbes
are
essential
steps
toward
unlocking
full
potential
microbiota-derived
biocatalysts.
Язык: Английский
Ultra-Processed Food Consumption as a Risk Factor for Gastrointestinal Cancer and Other Causes of Mortality in Southern Italy: A Competing Risk Approach
Nutrients,
Год журнала:
2024,
Номер
16(13), С. 1994 - 1994
Опубликована: Июнь 23, 2024
Background:
Ultra-Processed
Foods
(UPFs)
are
increasingly
consumed
worldwide,
even
in
regions
with
strong
dietary
traditions
like
the
Mediterranean
and
can
play
a
crucial
role
development
of
chronic
diseases,
including
cancer.
This
population-based
prospective
cohort
study
investigates
association
between
UPF
consumption
gastrointestinal
cancers
other
causes
mortality
Southern
Italy.
Methods:
Data
were
collected
from
4870
participants
MICOL
NUTRIHEP
cohorts.
The
EPIC
questionnaire
was
used
to
elicit
information
on
food
drink
UPFs
categorized
by
degree
processing
according
NOVA
classification.
Cox
proportional
hazards
regression
competing
risk
models
employed
for
statistical
analysis.
Results:
positively
associated
all-cause
mortality:
3rd
UFP
quartile,
as
compared
lowest,
had
27%
higher
death
(SHR
1.27
95%
CI,
1.03;
1.57),
while
highest
quartile
34%
1.34
1.00;
1.79).
Higher
intake
also
correlated
an
increased
risk,
especially
2nd
1.65,
CI:
1.01;
2.71)
4th
3.14
1.56;
6.32),
dose-dependent
effect.
For
cancers,
SHR
1.61
(95%
CI
2.54)
observed
quartile.
Conclusions:
Our
results
reinforce
link
cancer
emphasizing
urgent
need
interventions
targeting
patterns.
Язык: Английский
Real-world bisphenol A exposure not linked to microbiota dynamics in childhood obesity
mSystems,
Год журнала:
2024,
Номер
9(7)
Опубликована: Июль 3, 2024
Язык: Английский
Multi‐omics approach in gut and environmental microbiota research under the One Health concept
EFSA Journal,
Год журнала:
2024,
Номер
22
Опубликована: Дек. 1, 2024
Abstract
The
One
Health
concept,
although
formulated
two
decades
ago,
remains
challenging
to
implement.
It
necessitates
the
integration
of
numerous
scientific
disciplines,
diverse
techniques
and
various
professional
expertise.
Furthermore,
it
often
requires
collaboration
different
institutions,
encompassing
both
administrative
entities.
This
concept
posits
that
human
health
is
intrinsically
linked
dependent
on
well‐being
animals,
plants
broader
environment,
while
environment
not
only
sustains
life
but
can
also
serve
as
a
source
xenobiotics
affect
health‐disease
balance.
In
this
context,
all
components
potential
exposome,
entirety
factors
natures
influence
throughout
life,
must
be
considered
comprehensively.
Achieving
holistic
understanding
typically
demands
application
multiple
research
techniques,
known
multi‐omics
approach
adoption
an
integrated
method
for
data
analysis.
project
endeavoured
utilise
such
approach,
examining
from
origins:
(children
stool
gut
microbiota
analysis)
environmental
(groundwater
hyporheic
zone
microbial
analysis),
well
implementing
comprehensive
informatic
tools
processing.
Analysis
samples
revealed
significant
differences
in
composition
across
taxonomic
levels
between
normal
weight,
overweight
obese
children.
Additionally,
link
certain
composition,
body
weight
overall
status
was
identified.
groundwater
at
based
sampling
location
depth.
Key
geochemical
influencing
sample
diversity
were
promising
results
obtained
demonstrate
viability
methodology
pave
way
future
initiatives.
Язык: Английский