Environmental Science & Technology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 4, 2024
Metal exposures are closely related to childhood developmental health. However, their effects on the gut microbiome, which also impacts health, largely unexplored using microbiome multiomics including metagenome and metatranscriptome. This study examined associations of fecal profiles metal/element with species active functional pathways in 8- 12-year-old children (
Язык: Английский
Ageing Research Reviews, Год журнала: 2025, Номер 104, С. 102657 - 102657
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
2
Aging and Disease, Год журнала: 2023, Номер 14(6), С. 2081 - 2081
Опубликована: Янв. 1, 2023
In recent decades, gut microbiome research has experienced significant growth, driven by technological advances that enable quantifying bacterial taxa with greater precision. Age, diet, and living environment have emerged as three key factors influencing microbes. Dysbiosis, resulting from alterations in these factors, may lead to changes metabolites regulate pro- anti-inflammatory processes consequently impact bone health. Restoration of a healthy signature could mitigate inflammation potentially reduce loss associated osteoporosis or astronauts during spaceflight. However, current is hindered contradictory findings, insufficient sample sizes, inconsistency experimental conditions controls. Despite progress sequencing technology, defining across global populations remains elusive. Challenges persist identifying accurate metabolics, specific taxa, their effects on host physiology. We suggest attention be directed towards this issue Western countries the cost treating United States reaches billions dollars annually, expenses projected continue rising.
Язык: Английский
Процитировано
15
Journal of Ethnopharmacology, Год журнала: 2024, Номер 329, С. 118130 - 118130
Опубликована: Март 31, 2024
Язык: Английский
Процитировано
4
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Окт. 10, 2024
The interplay between the human microbiome and musculoskeletal system represents a burgeoning field of research with profound implications for understanding treating disorders. This review articulates pivotal role in modulating bone health, highlighting gut-bone axis as critical nexus potential therapeutic intervention. Through meticulous analysis recent clinical research, we underscore microbiome's influence on osteoporosis, sarcopenia, osteoarthritis, rheumatoid arthritis, delineating both direct indirect mechanisms by which microbiota could impact integrity function. Our investigation reveals novel insights into microbiota's contribution to density regulation, hormone production, immune modulation, nutrient absorption, laying groundwork innovative microbiome-based strategies disease management. Significantly, identify challenges hindering translation practice, including limitations current microbial sequencing techniques need standardized methodologies studies. Furthermore, highlight promising directions future particularly realm personalized medicine, where variability offers unique opportunities tailored treatment approaches. sets new agenda leveraging gut diagnosis, prevention, conditions, marking step toward integrating science care.
Язык: Английский
Процитировано
4
The FASEB Journal, Год журнала: 2025, Номер 39(5)
Опубликована: Март 6, 2025
Botanical drugs and probiotic supplements present safer alternative options for the prevention treatment of osteoporosis (OP). However, pathological disorders gut microbiota specific properties probiotics traditional Chinese medicine (TCM) significantly limit their therapeutic efficacy. Given favorable synergistic complementary effects between herbal medicines, a creative combination these approaches may address issue current limited A comprehensive analysis is necessary to provide detailed review potential combination, mechanisms behind synergy, scientific applications, future developments. There exists complex relationship OP, underlying regulatory are multidimensional, involving production pro-inflammatory metabolites, immune system disruption, impairment intestinal mucosal barrier. Furthermore, we analyzed connections probiotics, TCM, combined applications. We highlighted principle gain substantial organic which facilitates release active substances in increases bioavailability enhances delivery efficiency, exerts effects. The use TCM offers safe effective strategy managing OP presents an innovative promising direction development modern phytomedicine.
Язык: Английский
Процитировано
0
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Март 18, 2024
Background Gut microbiota has been associated with dermatological problems in earlier observational studies. However, it is unclear whether gut a causal function diseases. Methods Thirteen diseases were the subject of bidirectional Mendelian randomization (MR) research aimed at identifying potential links between and these Summary statistics for Genome-Wide Association Study (GWAS) obtained from public datasets. With goal evaluating estimates, five acknowledged MR approaches utilized along multiple testing corrections, inverse variance weighted (IVW) regression serving as main methodology. Regarding taxa that causally linked forward analysis, reverse was performed. A series sensitivity analyses conducted to test robustness estimates. Results The combined results methods analysis showed 94 suggestive significant relationships. In particular, genus Eubacterium_fissicatena_group increased risk developing psoriasis vulgaris (odds ratio [OR] = 1.32, p FDR 4.36 × 10 −3 ), family Bacteroidaceae (OR 2.25, 4.39 Allisonella 1.42, 1.29 −2 Bacteroides ) acne; Intestinibacter urticaria 1.30, 9.13 ). study revealed insufficient evidence relationship. addition, there no discernible horizontal pleiotropy or heterogeneity. Conclusion This provides novel insights into causality therapeutic preventive paradigms cutaneous conditions.
Язык: Английский
Процитировано
3
Life Sciences in Space Research, Год журнала: 2024, Номер 41, С. 171 - 180
Опубликована: Март 20, 2024
The space environment poses substantial challenges to human physiology, including potential disruptions in gastrointestinal health. Gut permeability has only recently become widely acknowledged for its cause adverse effects on a systemic level, rendering it critical factor investigate the context of spaceflight. Here, we propose that astronauts experience onset leaky gut during missions supported by transcriptomic and metagenomic analysis murine samples. A genetic map contributing intestinal was constructed from systematic review current literature. This referenced against our re-analysis three independent datasets which revealed significant changes gene expression patterns associated with barrier. Specifically, flight, observed reduction genes are crucial barrier function, goblet cell development, microbiota modulation, immune responses. Among rodent spaceflight studies, differential cytokines, chemokines, regulate mucin production post-translational modifications suggest similar dysfunction permeability. Metagenomic feces two studies notable probiotic, short chain fatty acid-producing bacteria an increase Gram-negative pathogens, Citrobacter rodentium, Enterobacter cloacea, Klebsiella aerogenes, Proteus hauseri promote LPS circulation, recipe disruption inflammatory activation. These findings emphasize need understand underlying mechanisms develop interventions maintain health space.
Язык: Английский
Процитировано
3
Aging and Disease, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
The characteristics of human aging manifest in tissue and organ function decline, heightening susceptibility to age-related ailments, thereby presenting novel challenges fostering sustaining healthy longevity. In recent years, an abundance research on has surfaced. Intriguingly, evidence suggests a pervasive correlation among gut microbiota, bodily functions, chronic diseases. From infancy later stages adulthood, individuals witness dynamic shifts microbiota composition. This microbial community is associated with deterioration (e.g., brain, bones, muscles, immune system, vascular system) heightened risk Thus, we present narrative review the microbiome both unhealthy contexts. Additionally, explore potential for adjustments physical health based analysis how targeting can potentially slow down process.
Язык: Английский
Процитировано
3
Journal of Bone and Mineral Research, Год журнала: 2024, Номер 39(2), С. 95 - 105
Опубликована: Янв. 3, 2024
Laparoscopic sleeve gastrectomy (LSG), the most common bariatric surgical procedure, leads to durable weight loss and improves obesity-related comorbidities. However, it induces abnormalities in bone metabolism. One unexplored potential contributor is gut microbiome, which influences metabolism altered after surgery. We characterized relationship between microbiome skeletal health severe obesity LSG. In a prospective cohort study, 23 adults with underwent assessment stool collection preoperatively 6 mo Gut microbial diversity composition were using 16S rRNA gene sequencing, fecal concentrations of short-chain fatty acids (SCFA) measured LC-MS/MS. Spearman's correlations PERMANOVA analyses applied assess relationships measures including serum turnover markers (C-terminal telopeptide type 1 collagen [CTx] procollagen N-terminal propeptide [P1NP]), areal BMD, intestinal calcium absorption, calciotropic hormones. Six months LSG, CTx P1NP increased (by median 188% 61%, P < .01) femoral neck BMD decreased (mean -3.3%, .01). Concurrently, there was decrease relative abundance phylum Firmicutes. Although no change overall or SCFA those greater within-subject community (β-diversity) postoperatively had increases level (ρ = 0.48, .02) at -0.43, .04). addition, within-participant shifts richness/evenness (α-diversity) associated changes IGF-1 levels 0.56, The lower postoperative butyrate concentration, 0.43, Meanwhile, larger higher These findings suggest that LSG-induced alteration may influence outcomes postoperatively, on formation are possible mechanisms.
Язык: Английский
Процитировано
2
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 11
Опубликована: Фев. 5, 2024
Glucocorticoid-induced osteoporosis (GIO) is a significant side effect of prolonged glucocorticoid (GC) treatment. Chronic GC treatment also leads to trabecular bone loss and gut microbiota dysbiosis in mice. The mechanistically linked GIO, which indicates that the can be targeted prevent GIO. Prunes, dried fruit prebiotic, have emerged literature as an effective for sex-steroid deficiency induced (primary osteoporosis). Prunes significantly alter composition both rodent models human studies. Therefore, we tested if dietary prune (DP) supplementation could GC-induced affect established model Sixteen-week-old, skeletally mature, female C57BL/6J mice were treated with subcutaneous 5 mg placebo or prednisolone pellet 8 weeks fed AIN-93M control diet modified include 5, 15, 25% (w/w) California powder. As expected, developed distal femur. More importantly, little 5% DP effectively prevented loss. Further, dose dependent increases volume fraction observed + 15% Amazingly, (non-GC treated) groups, caused ∼3-fold increase femur fraction; this sizable response has not been previously healthy natural treatments. Along striking on health, led drastic shifts several specific changes are strongly associated health. Taken together, these results first demonstrate prevents negative effects therapy health associates microbiota.
Язык: Английский
Процитировано
2