SARS-CoV-2 anti-RBD and anti-N protein responses are differentially regulated between mother-child pairs: insight from a national study cohort at the Faroe Islands DOI Creative Commons
Ida Jarlhelt, Cecilie Bo Hansen, Laura Pérez‐Alós

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 3, 2024

Background Knowledge about SARS-CoV-2 antibody dynamics in neonates and direct comparisons with maternal responses are not well established. This study aimed to characterize directly compare the infant response a national birth cohort from Faroe Islands. Methods The levels of immunoglobulins (Ig) targeting receptor binding domain (RBD) spike protein nucleocapsid (N protein) were investigated blood umbilical cord neonates. included 537 565 mothers Islands, follow-up samples collected 12 months after birth. Multiple linear regression models used assess associations parameters neonatal Ig pregnancy outcomes. Results finding showed that acquired varying antibodies through transplacental transfer, significantly influenced by mother’s vaccination infection status. also found presence RBD associated gestational age APGAR scores. Furthermore, anti-RBD -N protein-specific during exhibited differences between children. N maintained at cohort, while only was children’s cohort. Conclusion In conclusion, SARS-CoV-2-specific immune newborns rely on immunity, persistence Igs appears be differently regulated provides new insights into underscores nuanced relationship factors humoral responses.

Язык: Английский

SARS-CoV-2 anti-RBD and anti-N protein responses are differentially regulated between mother-child pairs: insight from a national study cohort at the Faroe Islands DOI Creative Commons
Ida Jarlhelt, Cecilie Bo Hansen, Laura Pérez‐Alós

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 3, 2024

Background Knowledge about SARS-CoV-2 antibody dynamics in neonates and direct comparisons with maternal responses are not well established. This study aimed to characterize directly compare the infant response a national birth cohort from Faroe Islands. Methods The levels of immunoglobulins (Ig) targeting receptor binding domain (RBD) spike protein nucleocapsid (N protein) were investigated blood umbilical cord neonates. included 537 565 mothers Islands, follow-up samples collected 12 months after birth. Multiple linear regression models used assess associations parameters neonatal Ig pregnancy outcomes. Results finding showed that acquired varying antibodies through transplacental transfer, significantly influenced by mother’s vaccination infection status. also found presence RBD associated gestational age APGAR scores. Furthermore, anti-RBD -N protein-specific during exhibited differences between children. N maintained at cohort, while only was children’s cohort. Conclusion In conclusion, SARS-CoV-2-specific immune newborns rely on immunity, persistence Igs appears be differently regulated provides new insights into underscores nuanced relationship factors humoral responses.

Язык: Английский

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