Polyphenol-Rich Aronia melanocarpa Fruit Beneficially Impact Cholesterol, Glucose, and Serum and Gut Metabolites: A Randomized Clinical Trial

Foods, Год журнала: 2024, Номер 13(17), С. 2768 - 2768

Опубликована: Авг. 30, 2024

Polyphenol-rich Aronia fruits have great potential as a functional food with anti-inflammatory, hypolipidemic, and hypoglycemic biologic activities. However, clinical intervention trials investigating the impact of fruit consumption on human health are limited. A randomized, controlled, double-blinded, parallel trial was conducted using 14 subjects who ingested either 0 mL or 100 juice daily for 30 days. Anthropometric measurements, fasting, postprandial measures glucose lipid metabolism inflammation, 16S rRNA fecal microbial composition data, mass spectrometry-acquired serum metabolomic data were collected before after period. Data analyzed general linear models, ANOVA, t-tests. Daily prevented rise in cholesterol levels (β = −0.50, p 0.03) reduced −3.03, < 0.01). No difference community by condition identified at any taxonomic level, but decrease −18.2, 0.04) richness detected. Serum profiles indicated shifts associated central carbon decreases pro-inflammatory metabolites. Our study further informs development polyphenol-based dietary strategies to lower metabolic disease risk.

Язык: Английский

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SARS-CoV-2 infection unevenly impacts metabolism in the coronal periphery of the lungs

iScience, Год журнала: 2025, Номер 28(2), С. 111727 - 111727

Опубликована: Янв. 2, 2025

Язык: Английский

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Metabolomic profile of severe COVID-19 and a signature predictive of progression towards severe disease status: a prospective cohort study (METCOVID)

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 10, 2025

Язык: Английский

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Starve a cold or feed a fever? Identifying cellular metabolic changes following infection and exposure to SARS-CoV-2

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0305065 - e0305065

Опубликована: Фев. 12, 2025

Viral infections induce major shifts in cellular metabolism elicited by active viral replication and antiviral responses. For the virus, harnessing evading changes that limit are essential for productive replication. In contrast, response to infection disrupts metabolic pathways prevent promote an state host cell neighboring bystander cells. This competition between virus results measurable differ depending on type, extracellular environment. The resulting can be observed analyzed using global profiling techniques identify critical either or defense. SARS-CoV-2 is a respiratory exhibit broad tissue tropism diverse, yet inconsistent, symptomatology. While factors determine presentation severity of remain unclear, syndromes associated with more severe manifestations disease. Despite these observations knowledge gap remains responses infection. Using well-established untargeted metabolomics analysis workflow, we compared human lung carcinoma We identified significant correlate non-productive information characterizing contribute could targeted therapeutic interventions

Язык: Английский

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Neutrophil extracellular traps and macrophage activation contibute to thrombosis and post-covid syndrome in SARS-CoV-2 infection

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 24, 2025

SARS-CoV-2 infection activates macrophages and induces the release of neutrophil extracellular traps (NETs). Excess NETs is linked to inflammatory thrombotic complications observed in COVID-19. To explore impact macrophage activation on SARS-CoV-2-infected patients who developed complications. We included 30 from first (March 2020) second wave (July 2021), collecting two plasma samples at diagnosis seven days later. Data demographics, comorbidities, basic analytical data were compiled. markers (myeloperoxidase (MPO), elastase (NE), p-selectin (P-SEL) S100A8/S100A9 heterodimer (MRP)) (Chitotriosidase activity (ChT), CCL18/PARC YKL-40) measured. The had higher incidences post-COVID syndrome, ICU admissions, mortality. Patients each showed elevated blood cells, liver enzymes, coagulation time diagnosis, with fibrinogen D-Dimer differing between waves. NET markers, NE, MPO, MRP, DNAse, ChT, CCL18 elevated, while P-SEL, cfDNA, YKL-40 decreased if compared controls. A decrease NE DNAse a link lower levels these versus without This study emonstrates alterations COVID-19 patients, indicating an imbalance response regulation.

Язык: Английский

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Optimizing Clinical Management of COVID-19: A Predictive Model for Unvaccinated Patients Admitted to ICU

Pathogens, Год журнала: 2025, Номер 14(3), С. 230 - 230

Опубликована: Фев. 27, 2025

This study investigates the impact of immunological and clinical factors on COVID-19 outcomes among unvaccinated individuals. A cohort 42 patients admitted to an intensive care unit was analyzed, focusing age, comorbidities, inflammatory cytokines (IL-6, TNF-α), anti-SARS-CoV-2 spike protein antibody levels (IgG) assess their influence hospital stay duration, recovery time, complications, mortality rates. The findings revealed that advanced cardiovascular disease, elevated pro-inflammatory significantly heightened risks severe complications mortality. Conversely, low IgG correlated with prolonged stays slower recovery. Multivariate analysis identified high IL-6 TNF-α as strong predictors adverse outcomes. research emphasizes need for early monitoring targeted management strategies mitigate COVID-19, especially high-risk populations.

Язык: Английский

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The association between mortality due to COVID-19 and coagulative parameters: a systematic review and meta-analysis study

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 2, 2024

This systematic review and meta-analysis study evaluated the association between mortality due to COVID-19 coagulative factors. A search was conducted on electronic databases including PubMed, Scopus, Web of Science from beginning pandemic until October 2024 identify relevant studies patients their laboratory findings related coagulation markers outcome. Eligibility criteria were defined based PICO framework, data extraction performed by two authors independently using a standardized sheet. Statistical analysis accomplished random effects model, heterogeneity among assessed I2 test. R RStudio used for statistical visualization. Our literature yielded 6969 studies, with 48 meeting inclusion our meta-analysis. The mean platelet count significantly lower in deceased compared survivors (20.58), while activated partial thromboplastin time (aPTT) fibrinogen levels did not show significant differences. pooled difference D-Dimer, International Normalized Ratio (INR), prothrombin (PT) survived (-2.45, -0.10, -0.84, respectively). These suggest that count, INR, PT may serve as potential indicators patients. results revealed reduction individuals when survivors. However, no distinctions observed aPTT survivor groups. On other hand, there noticeable variations estimated PT, D-Dimer levels, higher values group those who survived.

Язык: Английский

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Host metabolomic responses in recurrent P. vivax malaria

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Март 27, 2024

Abstract Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as promising tool combating disease. The study evaluated plasma metabolomic profiles of patients recurrent and non-recurrent malaria in Brazilian Amazon. Metabolites extracted from -infected were subjected to LC–MS analysis. Untargeted was applied investigate metabolic profile two groups. Overall, 51 59 included study. Longitudinal analysis revealed 52 37 significant metabolite features participants, respectively. Recurrence associated disturbances eicosanoid metabolism. Comparison between groups suggest alterations vitamin B6 (pyridoxine) metabolism, tyrosine 3-oxo-10-octadecatrienoate β-oxidation, alkaloid biosynthesis II. Integrative network enrichment other pathways phenotype, including butanoate aspartate asparagine N-glycan biosynthesis. metabolites predicted our potential biomarkers recurrence provide insights into targets antimalarial development against .

Язык: Английский

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Metabolic pathways altered by air pollutant exposure in association with coagulation function among the rural elderly

Journal of Hazardous Materials, Год журнала: 2024, Номер 478, С. 135507 - 135507

Опубликована: Авг. 13, 2024

Air pollution exposure has been linked with coagulation function. However, evidence is limited for the relationships between air pollution, function and metabolomics in humans. We recruited a panel of 130 rural elderly from Chayashan township China, all whom were free pre-existing cardiovascular diseases had provided residential address information. conducted clinical examinations collected blood samples these detection biomarkers (e.g, activated partial thromboplastin time, fibrinogen, thrombin prothrombin time) untargeted metabolites both December 2021 August 2022. used mini ambient quality monitor to measure mean levels five pollutants (e.g., PM

Язык: Английский

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Role of gasotransmitters in necroptosis

Experimental Cell Research, Год журнала: 2024, Номер 442(2), С. 114233 - 114233

Опубликована: Авг. 30, 2024

Язык: Английский

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