Biological Activity of Selenium and Its Impact on Human Health

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2633 - 2633

Опубликована: Янв. 30, 2023

Selenium (Se) is a naturally occurring metalloid element essential to human and animal health in trace amounts but it harmful excess. Se plays substantial role the functioning of organism. It incorporated into selenoproteins, thus supporting antioxidant defense systems. Selenoproteins participate metabolism thyroid hormones, control reproductive functions exert neuroprotective effects. Among elements, has one narrowest ranges between dietary deficiency toxic levels. Its level toxicity may depend on chemical form, as inorganic organic species have distinct biological properties. Over last decades, optimization population intake for prevention diseases related or excess been recognized pressing issue modern healthcare worldwide. Low selenium status associated with an increased risk mortality, poor immune function, cognitive decline, dysfunction. On other hand, concentrations slightly above its nutritional levels shown adverse effects broad spectrum neurological increase type-2 diabetes. Comprehension biochemical pathways under normal physiological conditions therefore important elucidate effect diseases. This review gives overview highlighting body. The activity Se, mainly performed through epigenetic discussed. Moreover, brief phytoremediation rhizofiltration approaches reported.

Язык: Английский

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Selenium: An Antioxidant with a Critical Role in Anti-Aging

Molecules, Год журнала: 2022, Номер 27(19), С. 6613 - 6613

Опубликована: Окт. 5, 2022

Aging is characterized by an imbalance between damage inflicted reactive oxygen species (ROS) and the antioxidative defenses of organism. As a significant nutritional factor, trace element selenium (Se) may remodel gradual spontaneous physiological changes caused oxidative stress, potentially leading to disease prevention healthy aging. Se involved in improving antioxidant defense, immune functions, metabolic homeostasis. An inadequate status reduce human life expectancy accelerating aging process or increasing vulnerability various disorders, including immunity dysfunction, cancer risk. This review highlights available studies on effective role mechanisms shows potential clinical implications related its consumption. The main sources organic advantages nanoformulations were also discussed.

Язык: Английский

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Selenium Biofortification: Strategies, Progress and Challenges

Agriculture, Год журнала: 2023, Номер 13(2), С. 416 - 416

Опубликована: Фев. 10, 2023

Selenium (Se) is an essential trace element for humans and animals. Its necessity plants still under examination. Due to the contradictory nature of Se its significance, it has received much interest in recent years. deficiency can be harmful humans, yet almost a billion people are deficient. been associated with cancers, impairment organs, number other ailments. The biofortification livestock guaranteed practice increase human selenium consumption. Strategies such as foliar spraying, direct application feed, injections have employed. shown additional beneficial effects livestock. In plants, reported mitigate different types stress yield. animal biofortification, reduce detrimental ailments promote healthy growth. nevertheless, confronts difficulties. For instance, bulk biofortified products must prepared before consumption, lowering concentration. objective this review convey current understanding animals, well difficulties, taking into account both consequences benefits biofortification.

Язык: Английский

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Antioxidant Metabolism Pathways in Vitamins, Polyphenols, and Selenium: Parallels and Divergences

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2600 - 2600

Опубликована: Фев. 23, 2024

Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance between oxygen and nitrogen species in the body its ability to neutralize them. These generated by both internal external factors can damage cellular lipids, proteins, DNA. Antioxidants prevent or slow down oxidation process interrupting transfer of electrons substances agents. This is particularly important at level because reactions lead formation FR contribute various diseases. As we age, RS accumulates leads organ dysfunction age-related disorders. Polyphenols; vitamins A, C, E; selenoproteins possess antioxidant properties may have a role preventing treating certain human diseases associated with RS. In this review, explore current evidence on potential benefits dietary supplementation investigate intricate connection SIRT1, crucial regulator aging longevity; transcription factor NRF2; polyphenols, vitamins, selenium. Finally, discuss positive effects molecules, such as reducing RS, their slowing several

Язык: Английский

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Selenoproteins: Zoom-In to Their Metal-Binding Properties in Neurodegenerative Diseases

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1305 - 1305

Опубликована: Фев. 3, 2025

Selenoproteins contain selenium (Se), which is included in the 21st proteinogenic amino acid selenocysteine (Sec). Selenium (Se) an essential trace element that exerts its biological actions mainly through selenoproteins. have crucial roles maintaining healthy brain activity. At same time, brain-function-associated selenoproteins may also be involved neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s (PD). The GPx4 (glutathione peroxidase 4), GPx1 1), SELENOP (selenoprotein P), SELENOK K), SELENOS S), SELENOW W), SELENOT T) are highly expressed, specifically AD-related regions being closely correlated to function. Only a few selenoproteins, mentioned above (especially SELENOP), can bind transition heavy metals. Metal ion homeostasis accomplishes vital physiological function of brain. Dyshomeostasis these metals induces entertains diseases. In this review, we described some proposed established mechanisms underlying properties above-mentioned having characteristic feature binding or

Язык: Английский

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Brazil nut (Bertholletia excelsa Bonpl.) in health and disease: A narrative review

Food Chemistry, Год журнала: 2025, Номер unknown, С. 143425 - 143425

Опубликована: Фев. 1, 2025

Язык: Английский

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Probiotic-driven advancement: Exploring the intricacies of mineral absorption in the human body

Food Chemistry X, Год журнала: 2023, Номер 21, С. 101067 - 101067

Опубликована: Дек. 13, 2023

The interplay between probiotics and mineral absorption is a topic of growing interest due to its great potential for human well-being. Minerals are vital in various physiological processes, deficiencies can lead significant health problems. Probiotics, beneficial microorganisms residing the gut, have recently gained attention their ability modulate mitigate deficiencies. aim present review investigate intricate connection key minerals such as calcium, selenium, zinc, magnesium, potassium. However, variability probiotic strains, dosages, alongside unique composition individuals gut microbiota, pose challenges establishing universal guidelines. An improved understanding these mechanisms will enable development targeted interventions optimize promote health.

Язык: Английский

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Selenium intake and multiple health-related outcomes: an umbrella review of meta-analyses

Frontiers in Nutrition, Год журнала: 2023, Номер 10

Опубликована: Сен. 13, 2023

Selenium is an essential trace metalloid element that associated with fundamental importance to human health. Our umbrella review aimed evaluate the quality of evidence, validity, and biases in relationship between selenium intake health-related outcomes according published systematic reviews pooled data meta-analyses. a decreased risk digestive system cancers, all-cause mortality, depression, Keshan disease, when children reduce Kashin-Beck disease. Additionally, supplementation can improve sperm quality, polycystic ovary syndrome, autoimmune thyroid cardiovascular infective outcomes. also has concentration serum lipids including total cholesterol very low-density lipoprotein cholesterol. However, no evidence shown better among patients intensive care units. Furthermore, may be related higher type 2 diabetes non-melanoma skin cancers. Moreover, most included studies are evaluated as low our assessment. Based on study findings limited advantages intake, it not recommended receive extra supplementary for general populations, should continued whose selenium-deficient status been corrected.

Язык: Английский

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Selenium volatilization in plants, microalgae, and microorganisms

Heliyon, Год журнала: 2024, Номер 10(4), С. e26023 - e26023

Опубликована: Фев. 1, 2024

The augmented prevalence of Se (Se) pollution can be attributed to various human activities, such as mining, coal combustion, oil extraction and refining, agricultural irrigation. Although is vital for animals, humans, microorganisms, excessive concentrations this element give rise potential hazards. Consequently, numerous approaches have been devised mitigate pollution, encompassing physicochemical techniques bioremediation. recognition volatilization a strategy mitigating in contaminated environments underscored review. This study delves into the mechanisms organisms, including plants, microalgae, microorganisms. By assessing efficacy removal identifying rate-limiting steps associated with volatilization, paper provides insightful recommendations mitigation. Constructed wetlands are cost-effective environmentally friendly alternative treatment volatilization. fate, behavior, bioavailability, toxicity within complex environmental systems comprehensively reviewed. knowledge forms basis developing management plans that aimed at contamination protecting ecosystems.

Язык: Английский

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Insight into selenium biofortification and selenite metabolic mechanism of Monascus ruber through physicochemical characterization and transcriptome analysis

Food Chemistry, Год журнала: 2024, Номер 455, С. 139740 - 139740

Опубликована: Май 21, 2024

Язык: Английский

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