Synthesis of conjugates of ipidacrine with oxa/azaheterocycles and their potential as agents for the treatment of Alzheimer’s disease
Russian Chemical Bulletin,
Год журнала:
2024,
Номер
73(6), С. 1755 - 1765
Опубликована: Июнь 1, 2024
Язык: Английский
Purine nucleosides as selective inhibitors of butyrylcholinesterase – a multidisciplinary study
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
A
multidisciplinary
study
of
purine
nucleoside
selective
BuChE
inhibitors,
covering
docking,
synthesis,
biological
evaluation
and
cytotoxic
assays.
Язык: Английский
Influence of the sulfonyl group on the biological activity of 2-sulfonarylhydrazinylidene 1,3-dicarbonyl compounds
Russian Chemical Bulletin,
Год журнала:
2024,
Номер
73(6), С. 1766 - 1774
Опубликована: Июнь 1, 2024
Язык: Английский
Conjugates of amiridine and salicylic derivatives as promising multifunctional CNS agents for potential treatment of Alzheimer's disease
Archiv der Pharmazie,
Год журнала:
2024,
Номер
358(1)
Опубликована: Дек. 17, 2024
New
conjugates
of
amiridine
and
salicylic
derivatives
(salicylamide,
salicylimine,
salicylamine)
with
different
lengths
alkylene
spacers
were
designed,
synthesized,
evaluated
as
potential
multifunctional
central
nervous
system
therapeutic
agents
for
Alzheimer's
disease
(AD).
Conjugates
demonstrated
high
acetylcholinesterase
(AChE)
butyrylcholinesterase
(BChE)
inhibition
(IC
Язык: Английский
Affinity ultrafiltration screening, multi-target extraction, and comprehensive activity verification of acetylcholinesterase inhibitors in the food additive Corydalis yanhusuo
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
Corydalis
yanhusuo
possesses
strong
medicinal
value
and
is
used
in
certain
regions
for
soup
making,
wine
frying,
vinegar
processing,
other
edible
processes.
The
anti-Alzheimer’s
disease
(AD)
traditional
Chinese
patent
medicine
"Yangxue
Qingnao
Granules"
contains
C.
yanhusuo.
To
explore
the
anti-dementia
components
of
yanhusuo,
this
study
acetylcholinesterase
(AChE)
as
pointcut
screened,
extracted,
separated,
evaluated
biological
activity
AChE
inhibitors
For
first
time,
affinity
ultrafiltration
combined
with
a
matrix
comprehensive
evaluation
inhibitor
was
used,
prediction
analysis
conducted
using
binding-degree
growth
trend
fitting
diagram.
response
surface
pairwise
Euclidean
distances
Non-dominated
Sorting
Genetic
Algorithm
III
technology
employed
to
classify
various
compounds,
thereby
optimizing
extraction
multiple
active
ingredients.
Semi-preparative
high-performance
liquid
chromatography
separate
purify
compounds.
inhibitory
effects
mechanisms
action
ingredients
on
were
verified
through
enzymatic
reaction
kinetics,
potential
anti-AD
network
pharmacology.
Finally,
differences
compound
comprehensively
time
Pearson
correlation
matrix.
results
revealed
that
six
compounds
exhibited
significant
binding
affinities
site.
This
provides
valuable
insights
into
their
properties,
promotes
development
from
food
medicines,
an
approach
reduce
side
associated
synthetic
drugs.
reference
exploration
functional
materials
resources.
Язык: Английский
Conjugates of anticholinesterase drugs ipidacrine and tacrine with thiouracils: synthesis and biological properties
Russian Chemical Bulletin,
Год журнала:
2024,
Номер
73(11), С. 3399 - 3409
Опубликована: Ноя. 1, 2024
Язык: Английский