A Novel AHAS-Inhibiting Herbicide Candidate for Controlling Leptochloa chinensis: A Devastating Weedy Grass in Rice Fields DOI
Yinglu Chen,

Yitao Yan,

Jie Chen

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(29), С. 16140 - 16151

Опубликована: Июль 15, 2024

Given the prevalence of malignant weed Chinese Sprangletop (Leptochloa chinensis (L.) Nees) in rice fields, development novel herbicides against this has aroused wide interest. Here, we report a diphenyl ether-pyrimidine hybrid, DEP-5, serving as systematic pre/postemergence herbicide candidate for broad-spectrum control specifically L. chinensis. Notably, DEP-5 exhibits over 80% herbicidal activity resistant biotypes even at 37.5 g a.i./ha under greenhouse conditions and complete 150 fields. We uncover that acts noncompetitive inhibitor acetohydroxyacid synthase (AHAS) with an inhibition constant (Ki) 39.4 μM. propose binds to AHAS two hydrophobic-driven binding modes differ from commercial inhibitors. Overall, these findings demonstrate great potential be developed into inspire fresh concepts AHAS-inhibiting design.

Язык: Английский

A Novel AHAS-Inhibiting Herbicide Candidate for Controlling Leptochloa chinensis: A Devastating Weedy Grass in Rice Fields DOI
Yinglu Chen,

Yitao Yan,

Jie Chen

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(29), С. 16140 - 16151

Опубликована: Июль 15, 2024

Given the prevalence of malignant weed Chinese Sprangletop (Leptochloa chinensis (L.) Nees) in rice fields, development novel herbicides against this has aroused wide interest. Here, we report a diphenyl ether-pyrimidine hybrid, DEP-5, serving as systematic pre/postemergence herbicide candidate for broad-spectrum control specifically L. chinensis. Notably, DEP-5 exhibits over 80% herbicidal activity resistant biotypes even at 37.5 g a.i./ha under greenhouse conditions and complete 150 fields. We uncover that acts noncompetitive inhibitor acetohydroxyacid synthase (AHAS) with an inhibition constant (Ki) 39.4 μM. propose binds to AHAS two hydrophobic-driven binding modes differ from commercial inhibitors. Overall, these findings demonstrate great potential be developed into inspire fresh concepts AHAS-inhibiting design.

Язык: Английский

Процитировано

4