Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR)

The journal of nutrition health & aging, Год журнала: 2025, Номер 29(1), С. 100401 - 100401

Опубликована: Янв. 1, 2025

Aging, a universal and inevitable process, is characterized by progressive accumulation of physiological alterations functional decline over time, leading to increased vulnerability diseases ultimately mortality as age advances. Lifestyle factors, notably physical activity (PA) exercise, significantly modulate aging phenotypes. Physical exercise can prevent or ameliorate lifestyle-related diseases, extend health span, enhance function, reduce the burden non-communicable chronic including cardiometabolic disease, cancer, musculoskeletal neurological conditions, respiratory well premature mortality. influences cellular molecular drivers biological aging, slowing rates-a foundational aspect geroscience. Thus, PA serves both preventive medicine therapeutic agent in pathological states. Sub-optimal levels correlate with disease prevalence populations. Structured prescriptions should therefore be customized monitored like any other medical treatment, considering dose-response relationships specific adaptations necessary for intended outcomes. Current guidelines recommend multifaceted regimen that includes aerobic, resistance, balance, flexibility training through structured incidental (integrated lifestyle) activities. Tailored programs have proven effective helping older adults maintain their capacities, extending enhancing quality life. Particularly important are anabolic exercises, such Progressive resistance (PRT), which indispensable maintaining improving capacity adults, particularly those frailty, sarcopenia osteoporosis, hospitalized residential aged care. Multicomponent interventions include cognitive tasks hallmarks frailty (low body mass, strength, mobility, level, energy) thus preventing falls optimizing during aging. Importantly, PA/exercise displays characteristics varies between individuals, necessitating personalized modalities tailored conditions. Precision remains significant area further research, given global impact broad effects PA. Economic analyses underscore cost benefits programs, justifying broader integration into care adults. However, despite these benefits, far from fully integrated practice people. Many healthcare professionals, geriatricians, need more incorporate directly patient care, whether settings hospitals, outpatient clinics, Education about use isolated adjunctive treatment geriatric syndromes would do much ease problems polypharmacy widespread prescription potentially inappropriate medications. This intersection prescriptive practices offers promising approach well-being An strategy combines pharmacotherapy optimize vitality independence people whilst minimizing adverse drug reactions. consensus provides rationale promotion, prevention, management strategies Guidelines included dosages efficacy randomized controlled trials. Descriptions beneficial changes, attenuation phenotypes, role disability provided. The sarcopenia, neuropsychological emphasized. Recommendations bridge existing knowledge implementation gaps integrate mainstream Particular attention paid it applies geroscience, inter-individual variability adaptation demonstrated adult cohorts. Overall, this foundation applying current base an population span

Язык: Английский

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Polypharmacy Prevalence Among Older Adults Based on the Survey of Health, Ageing and Retirement in Europe: An Update

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1330 - 1330

Опубликована: Фев. 17, 2025

Polypharmacy, a common condition among the older population, is associated with adverse outcomes, including higher mortality, falls and hospitalization rates, drug reactions, drug-drug interactions, medication nonadherence, consequently increased healthcare costs. Background/Objectives: This study aims to explore prevalence of polypharmacy its factors adults across 27 European countries Israel. Methods: In this cross-sectional analysis, we used data from participants aged 65 years or Wave 9 Survey Health, Aging, Retirement in Europe (SHARE) database. The variables studied were classified into following categories: sociodemographic, behavioral factors, physical functioning, health, mental living conditions. Results: Our results showed an overall 36.2%, ranging 25.0 51.8%. Slovenia, Greece, Switzerland lowest prevalence, whereas Portugal, Israel, Poland where was highest. Polypharmacy shown be all categories. Conclusions: highly prevalent population. Identification polypharmacy, such as those identified study, important identify monitor groups, which are most vulnerable polypharmacy. Interventions designed reduce should consider these associations.

Язык: Английский

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Waving the red or green flag for pragmatic treatment options in older adults

BDJ Team, Год журнала: 2025, Номер 12(1), С. 24 - 28

Опубликована: Янв. 17, 2025

Язык: Английский

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Reducing polypharmacy through deprescribing in the emergency department

Medicine, Год журнала: 2025, Номер 104(10), С. e41590 - e41590

Опубликована: Март 7, 2025

Polypharmacy, the use of multiple medications, is a prevalent issue globally that contributes to increased healthcare costs and places additional burdens on patients' organs. This study aims deprescribe prevent polypharmacy in emergency department. We conducted retrospective review randomly selected medical records from Internal Medicine Department Taipei MacKay Emergency Department, spanning August 1, 2023, October 31, 2023. For cases identified as involving polypharmacy, pharmacists provided medication education using Team Resource Management Polypharmacy Interview Guide, while social workers contacted patients via phone recommend follow-up visits for deprescribing. Patients experiencing were significantly older than those appropriate regimens (79.8 vs 67.3 years, P = .002). After deprescribing interventions, average number medications was 5.9 higher receiving prescriptions (9.2 3.3, .001). The most common conditions associated with diabetes mellitus, hypertension, arrhythmia. poses significant management challenge, affected taking an 6.9 more treatment regimens. resource module our team successfully reduced incidence by 8.4%

Язык: Английский

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Potentially Inappropriate Prescriptionss in End-of-Life Cancer Patients in Home-Based Hospice Care

Journal of Pain and Symptom Management, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Polypharmacy and inappropriate prescribing are prevalent among end-of-life cancer patients, potentially compromising symptom management quality of life. Limited data available on medications (PIMs) omissions (PPOs) opioid in South Korea, particularly home-based hospice care settings. This study aimed to evaluate the prevalence PIMs PPOs advanced patients referred identify factors associated with these issues. A retrospective observational included 102 a single center's between November 2022 2023. were assessed using STOPPFrail criteria, while defined as inadequate for moderate severe pain. Logistic regression analysis identified PPOs. observed 40.2% higher those over 70 years old (48.7%) multiple comorbidities. Statins (25.5%) antihypertensives (29.4%) most common PIMs. Among pain, 45.5% experienced due prescriptions. Older age (OR 3.90, p < 0.01) comorbidities 20.90, significantly PIMs, diabetes was linked 2.00, = 0.01). The findings highlight critical gaps medication patients. Systematic deprescribing protocols improved strategies address stigma hesitancy essential align treatments goals enhance patient

Язык: Английский

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Frailty, multimorbidity, and polypharmacy: Proposal of the new concept of the geriatric triangle

Geriatrics and gerontology international/Geriatrics & gerontology international, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

As people age, the prevalence of frailty, multimorbidity, and polypharmacy increases, presenting significant challenges in geriatric medicine. These three elements are interrelated a bidirectional manner, forming what can be termed “geriatric triangle.” The complexity their interconnections means that addressing each issue isolation is insufficient for achieving an effective resolution. Thus, comprehensive understanding this triangle essential appropriate management. This review aims to illuminate relationships within offer insights into potential strategies managing these interconnected challenges. Geriatr Gerontol Int 2025; ••: ••–•• .

Язык: Английский

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Frailty, polypharmacy, malnutrition, chronic conditions, and quality of life in the elderly: Large population-based study (Preprint)

JMIR Public Health and Surveillance, Год журнала: 2024, Номер 10, С. e50617 - e50617

Опубликована: Авг. 15, 2024

Background Aging, a significant public health issue, is associated with multiple concurrent chronic diseases and aging-related conditions (geriatric syndromes). Objective This study aims to investigate the impact of age on geriatric syndromes intercorrelations between quality life (QoL) in older adults (aged ≥65 years) at population level. Methods A large representative sample was randomly selected from county China, Feidong, 17 towns 811,867 residents. Multiple conditions, (frailty, polypharmacy, malnutrition), QoL were assessed compared. Associations demographic information using multivariable-adjusted logistic regression. Intercorrelations age, syndromes, investigated both correlation analysis restricted cubic splines–based dose-response analysis. Results Older comprised 43.42% (3668/8447) entire population. The prevalence frailty, premalnutrition or malnutrition, impaired (median 73, IQR 69-78 years; 1871/3668, 51% men) 8.26% (303/3668), 15.59% (572/3668), 3.22% (118/3668), 10.8% (396/3668), respectively. Different sex subgroups mostly had similar (except that frailty occurred more often age). Premalnutrition malnutrition lower frequency obesity higher constipation, polypharmacy diabetes constipation hernia, hypertension, diabetes, physical disability, constipation. Mini Nutritional Assessment–Short Form, Groningen Frailty Indicator, EQ-5D-5L scores, as well number medications used, predicted each other QoL. Impaired polypharmacy. At 1.5-year follow-up, linked baseline, baseline. Causal mediation analyses showed mediated link worse Conclusions In this population-based adults, ≥1 syndromes. Geriatric intercorrelated with, predictive of, QoL; causal relationships existed QoL, being mediators. findings might be biased by residual confounding factors. It important perform personalized syndrome assessments stratified condition; active prevention intervention for, any help reduce others improve

Язык: Английский

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Association between polypharmacy and cognitive impairment in older adults: A systematic review and meta-analysis

Geriatric Nursing, Год журнала: 2024, Номер 59, С. 330 - 337

Опубликована: Авг. 6, 2024

Язык: Английский

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Deprescribing makes me weep

BMJ, Год журнала: 2024, Номер unknown, С. q1620 - q1620

Опубликована: Июль 23, 2024

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Generating and translating evidence for safe and effective medication management in aged care homes

British Journal of Clinical Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Generating and translating high‐quality evidence is integral to providing safe effective medication management for residents of aged care homes. Residents are often under‐represented in trials effectiveness safety. This paper reviews opportunities challenges generating There an increasing number randomized controlled (RCTs) being conducted Observational studies can also help address the evidence‐practice gap arising from underrepresentation RCTs. Stepped‐wedge helix counterbalanced designs may overcome limitations traditional RCTs evaluating interventions setting. Strategies include building partnerships with homes organizations, using novel trial designs, leveraging existing data knowledge sharing through international platforms. quality indicators audit feedback, provision education training, engaging internal external stakeholders, development local action plans guideline implementation tools. emerging interest role brokers facilitate translation. Future directions strengthening research collaboration, industry partnerships, standardizing home support national comparisons, optimizing use technology. Initiatives improving access routinely collected administrative health conducting observational studies. should assess outcomes prioritized by ensure that strategies tailored their needs.

Язык: Английский

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