Efficacy and Safety of Phase 1 of Very Low Energy Ketogenic Therapy (VLEKT) in Subjects with Obesity and Mild Renal Impairment

Nutrients, Год журнала: 2025, Номер 17(4), С. 721 - 721

Опубликована: Фев. 18, 2025

Background: Obesity impairs renal function through direct mechanisms, such as proinflammatory adipocytokine production, and indirect including obesity-related comorbidities. Despite the increasing prevalence of obesity chronic kidney disease (CKD), clinical guidelines for their combined management remain lacking. Very Low Energy Ketogenic Therapy (VLEKT) has demonstrated efficacy in weight loss, but evidence on its safety individuals with mild impairment is limited. This study aimed to assess Phase 1 VLEKT impairment. Methods: cross-sectional included 73 overweight or (mean age 53.7 ± 8.8 years; BMI 35.3 4.2 kg/m2) an estimated glomerular filtration rate (eGFR) at least 60 mL/min/1.73 m2 (evaluated using CKD-EPI equation). Anthropometric (weight, BMI, waist circumference) biochemical parameters (fasting plasma glucose, insulin, cholesterol profile, triglycerides, AST, ALT, urea) were collected baseline after 45 (±2) days VLEKT. Results: At baseline, 54.8% participants had eGFR <90 m2, while 45.2% ≥ 90 no significant differences sex distribution. After VLEKT, both groups showed reductions (p < 0.001), circumference fasting glucose ≤ 0.004), insulin HOMA-IR total LDL LDL/HDL ratio 0.002), triglycerides 0.009), AST 0.034), ALT 0.009). Notably, significantly increased changes observed those m2. Conclusions: could effectively promote loss metabolic improvements without compromising function, even Further research warranted confirm outcomes across all protocol phases.

Язык: Английский

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Ketogenic Diets for Body Weight Loss: A Comparison with Other Diets

Nutrients, Год журнала: 2025, Номер 17(6), С. 965 - 965

Опубликована: Март 10, 2025

With the prevalence of obesity and overweight increasing at an alarming rate, more researchers are focused on identifying effective weight loss strategies. The ketogenic diet (KD), used as a treatment in epilepsy management for over 100 years, is additionally gaining popularity method. Although its efficacy well documented, areas where it may be beneficial to other dietary approaches need carefully examined. objective this paper identify potential benefits KD alternative strategies based comprehensive literature review. It has been shown that bioenergetically efficient than strategies, inter alia owing effect curtailing hunger, improving satiety decreasing appetite (influence hunger hormones sensation hunger), inducing faster initial (associated with lower glycogen levels reduced water retention), controlling glycaemia insulinemia (directly attributable low-carbohydrate nature indirectly described). These effects accompanied by improved insulin sensitivity, inflammation (through ketone bodies avoidance pro-inflammatory sugars), pharmacological control (the diet’s mechanisms similar those medication but without side effects), positive impacts psychological factors food addiction. Based authors’ review latest research, reasonable conclude that, due these many additional health benefits, advantageous diet-based This important hypothesis deserves further exploration, which could achieved including outcome measures future clinical trials, especially when comparing different diets equal caloric value.

Язык: Английский

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Beneficial Effects of Butyrate on Kidney Disease

Nutrients, Год журнала: 2025, Номер 17(5), С. 772 - 772

Опубликована: Фев. 22, 2025

The gut microbiota influences and contributes to kidney health disease. Butyrate, a short-chain fatty acid molecule generated via the fermentation of bacterial catabolism nondigestible dietary fiber, has been shown exert numerous beneficial effects on disorders. objective this review was discuss latest findings protective butyrate variety animal models injury. We conducted PubMed search using title word "butyrate" keyword "kidney" generate our literature sources. covered in include ischemia-reperfusion renal injury, cisplatin- folic acid-induced septic diabetic disease (DKD), high-fat diet (HFD)-induced glomerulopathy, adenine-induced chronic (CKD), high-salt-induced T-2 toxin-induced injury birds. mechanisms that are most shared among these model studies antioxidative stress, anti-fibrosis, anti-inflammation, anti-cell death. This ends with suggestions for future potential approaches may modulate production well-being kidneys disorders review.

Язык: Английский

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A 6-Month mHealth Low-Carbohydrate Dietary Intervention Ameliorates Glycaemic and Cardiometabolic Risk Profile in People with Type 2 Diabetes

Nutrients, Год журнала: 2025, Номер 17(6), С. 937 - 937

Опубликована: Март 7, 2025

Aim: Mobile health (mHealth) applications have been reported to be effective in improving glycaemic control and cardiometabolic health, but mainly as part of shorter-term intervention studies. The aim this study is examine the effect ongoing Defeat Diabetes mHealth low-carbohydrate diet (LCD) on clinical markers risk after 6 months intervention. Methods: Data were collected via primary care physicians routine T2D monitoring. These included HbA1c (primary outcome), blood pressure, lipids, kidney liver function. Anthropometrics, well changes prescription diabetes, hypertension, dyslipidaemia medication, also recorded. Calculated variables, total cholesterol HDL-c, triglyceride waist height ratios, analysed profile. Three-day food records used assess dietary intake adherence. Univariate regression models examined from baseline months. Results: Ninety-four participants remained out ninety-nine at (mean age 59 ± 11 years, 55 females). After intervention, there significant reductions by −1.0% (95% CI: −1.3 −0.6), enzymes ALT (−9.3 U/L 95% CI −16.3 −2.4) GGT (−18.8 −31.4 −6.3) across cohort. In addition, was a reduction risk, measured calculated variables decrease circumference (−4.6 cm −8.9 −0.2). Conclusions: People with receiving LCD education resources through app (version 3.3.8) improved their Cardiometabolic profile function showed improvement. findings indicate that use an digital valuable adjunct management T2D.

Язык: Английский

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Myths and Facts Regarding Low-Carbohydrate Diets

Nutrients, Год журнала: 2025, Номер 17(6), С. 1047 - 1047

Опубликована: Март 17, 2025

As the prevalence of chronic diseases persists at epidemic proportions, health practitioners face ongoing challenges in providing effective lifestyle treatments for their patients. Even those patients on GLP-1 agonists, nutrition counseling remains a crucial strategy managing these conditions over long term. This paper aims to address concerns and who are interested low-carbohydrate or ketogenic diet, but have about its efficacy, safety, long-term viability. The authors this used approach researchers engaged study. reflects our opinion is not meant review diets systematically. In addressing common concerns, we hope show that has been well researched can no longer be seen as “fad diet” with adverse effects such impaired renal function increased risk heart disease. We also persistent questions patient adherence, affordability, environmental sustainability. perspective clinicians study application dietary interventions. While systematic review, all factual claims substantiated citations from peer-reviewed literature most rigorous recent science. To knowledge, first potential misconceptions comprehensively.

Язык: Английский

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Impact of an interactive dietary management program on nephrolithiasis patients in Taiwan

Discover Food, Год журнала: 2025, Номер 5(1)

Опубликована: Март 28, 2025

Язык: Английский

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Dietary Guidelines Post Kidney Transplant: Is This the Missing Link in Recovery and Graft Survival?

Transplant International, Год журнала: 2025, Номер 38

Опубликована: Апрель 3, 2025

The physiology of a transplanted kidney is affected from the moment it separated donor. risk complications arising surgery are highly associated with ischemic-reperfusion injury (IRI) due to effects hypoxia and oxidative stress during procurement, preservation reperfusion procedures. Hypoxia promotes formation reactive oxygen species (ROS) seems apparent that finding ways optimising metabolic milieu for would improve recovery graft survival. Studies have demonstrated benefits nutrition antioxidant compounds in mitigating disturbance energy supply cells post-transplant at improving long-term Particularly patients who may be nutritionally deficient following dialysis. Despite high incidence allograft failure, search literature grey reveals no medical nutriti on therapy guidelines beneficial nutrient intake aid transplant This narrative review aims summarise current knowledge specific macro micronutrients their effect survival perioperative period, up 1-year post transplant, optimise environment mitigate injury.

Язык: Английский

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Association between ketogenic diets and depression: A cross-sectional analysis of the NHANES 2005–2023 August

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Diabetic Kidney Disease: Contribution of Phenyl Sulfate Derived from Dietary Tyrosine upon Gut Microbiota Catabolism

Biomolecules, Год журнала: 2024, Номер 14(9), С. 1153 - 1153

Опубликована: Сен. 13, 2024

Deranged gut microbiota can release increased levels of uremic toxins leading to exacerbated kidney injury. In diabetic disease (DKD), phenyl sulfate (PS) derived from tyrosine catabolism by has been demonstrated be both an early diagnostic marker and a therapeutic target. this perspective article, we summarize PS generation pathways recent findings on injury in DKD. Increasing evidence shown that the underlying mechanisms PS-induced mainly involve oxidative stress, redox imbalance, mitochondrial dysfunction, which all may targeted attenuate For future research directions, think deeper understanding pathogenic role using variety animal models should investigated. Moreover, also suggest beneficial approaches could used mitigate deleterious effect kidney. These include caloric restriction, administration ketogenic drugs, diets or natural products; conducted under obese conditions.

Язык: Английский

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Trigger Warning: How Modern Diet, Lifestyle, and Environment Pull the Trigger on Autosomal Dominant Polycystic Kidney Disease Progression

Nutrients, Год журнала: 2024, Номер 16(19), С. 3281 - 3281

Опубликована: Сен. 27, 2024

Understanding chronic kidney disease (CKD) through the lens of evolutionary biology highlights mismatch between our Paleolithic-optimized genes and modern diets, which led to dramatically increased prevalence CKD in societies. In particular, Standard American Diet (SAD), high carbohydrates ultra-processed foods, causes conditions like type 2 diabetes (T2D), inflammation, hypertension, leading CKD. Autosomal dominant polycystic (ADPKD), a genetic form CKD, is characterized by progressive renal cystogenesis that leads failure. This review challenges fatalistic view ADPKD as solely disease. We argue that, just non-genetic dietary practices, lifestyle, environmental exposures initiate accelerate progression. Evidence shows carbohydrate overconsumption, hyperglycemia, insulin resistance significantly impact health. Additionally, factors dehydration, electrolyte imbalances, nephrotoxin exposure, gastrointestinal dysbiosis, microcrystal formation exacerbate ADPKD. Conversely, restriction, ketogenic metabolic therapy (KMT), antagonizing lithogenic risk show promise slowing Addressing triggers modifications lifestyle changes offers conservative, non-pharmacological strategy for modification comprehensive underscores urgency integrating diet into clinical management mitigate progression, improve patient outcomes, offer therapeutic choices can be implemented worldwide at low or no cost healthcare payers patients.

Язык: Английский

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