Опубликована: Янв. 1, 2024
Язык: Английский
Obesity, Год журнала: 2025, Номер unknown
Опубликована: Март 12, 2025
Abstract Objective The objective of this study was to estimate the 10‐year clinical benefits and economic value weight loss in a Swedish population with obesity using weight‐loss simulation model. Methods Data on prevalence costs associated obesity‐related complications (ORCs) were applied within an adapted model evaluate for 2023 over 10 years. incidence ORCs treatment random cohort 10,000 individuals estimated stable scenario four (5%–20%) scenarios. Results included 887,272 aged 20 60 Hypertension (24.1%), asthma (20.9%), dyslipidemia (18.3%), type 2 diabetes (10.6%) highly prevalent. For individuals, 5% 20% prevent years, leading annual savings between 9.0 million krona (SEK)/€0.8 (5% loss) 30.0 SEK/€2.6 (20%) by 2033. Conclusions Annual Sweden will double would be significant because reductions ORCs. Therefore, there is urgent need effectively treat morbidity.
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Background The integration of large language models (LLMs) such as GPT-4 into healthcare presents potential benefits and challenges. While LLMs show promise in applications ranging from scientific writing to personalized medicine, their practical utility safety clinical settings remain under scrutiny. Concerns about accuracy, ethical considerations, bias necessitate rigorous evaluation these technologies against established medical standards. Methods This study involved a comparative analysis using anonymized patient records setting the state West Bengal, India. Management plans for 50 patients with type 2 diabetes mellitus were generated by three physicians, who blinded each other's responses. These evaluated reference management plan based on American Diabetes Society guidelines. Completeness, necessity, dosage accuracy quantified Prescribing Error Score was devised assess quality plans. also assessed. Results indicated that physicians' had fewer missing medications compared those (p=0.008). However, GPT-4-generated included unnecessary (p=0.003). No significant difference observed drug dosages (p=0.975). overall error scores comparable between physicians (p=0.301). Safety issues noted 16% GPT-4, highlighting risks associated AI-generated Conclusion demonstrates while can effectively reduce prescriptions, it does not yet match performance terms completeness. findings support use supplementary tools healthcare, need enhanced algorithms continuous human oversight ensure efficacy artificial intelligence settings.
Язык: Английский
Процитировано
0
HORMONES, Год журнала: 2025, Номер unknown
Опубликована: Март 21, 2025
Язык: Английский
Процитировано
0
npj Digital Medicine, Год журнала: 2025, Номер 8(1)
Опубликована: Март 28, 2025
Although promising, the clinical impact of video conferencing between primary and secondary care specialists lacks trial evidence. We conducted a two-arm RCT (clinicaltrials.gov: NCT05268081) to evaluate whether four conferences over 12 months endocrinologists general practitioners improved medication for people with type 2 diabetes (T2D). Twenty-seven 100 practices in Aarhus, Denmark were matched randomized. Primary outcomes: proportion T2D 1) ischemic heart disease treated glucagon-like peptide 1 receptor agonist (GLP1-RA) and/or sodium glucose cotransporter inhibitor (SGLT2I), 2) micro/macro-albuminuria angiotensin-converting-enzyme-inhibitor (ACE) or angiotensin-2-receptorantagonist (AT2), 3) low-density lipoprotein >2.5 mmol/L statins. Results showed 17.6% difference [95% CI 4.6%; 30.7%] GLP1-RA/SGLT2I prescriptions minimal differences ACE/AT2 (−1.1% −2.8%; 0.6%]) statins (0.0% −3.5%; 3.6%]), attributed ceiling effect. Video can help bridge treatment gaps, particularly recently updated guidelines.
Язык: Английский
Процитировано
0
Clinical and Experimental Vaccine Research, Год журнала: 2025, Номер 14
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1572 - 1572
Опубликована: Дек. 9, 2024
Diabetes is a widespread metabolic illness. Mismanagement of diabetes can lead to severe complications that tremendously impact patients’ quality life. The assimilation nanotechnology in care holds the potential revolutionize treatment paradigms, improve patient outcomes, and reduce economic burden associated with this pervasive disease. This manuscript explores multifaceted utilization nanomaterials care, emphasizing unique features nano-based medication delivery methods smart drug mechanisms. Additionally, paper talks about research on nanocarrier-integrated oral, transdermal, inhalable insulin delivery; dendrimer- nanocarrier-coupled antisense oligonucleotide-driven gene therapy; implementation gold nanoparticles quantum dots for glucose surveillance; nucleic acid therapies. There are certain restrictions when using commonly available handle diabetes. In order increase efficacy safety, rapidly developing science also being explored employed medical biology. Nanomaterials like liposomes, dendrimers, niosomes, polymeric metallic nanocarriers, solid lipid among nanocarriers have been developed better various oral hypoglycemic agents comparison conventional These provide great control over elevated blood levels, making them one most intriguing promising technologies today. Furthermore, adding additional ligands allows more focused distribution while protecting encapsulated drugs.
Язык: Английский
Процитировано
2
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Апрель 22, 2024
Abstract Despite recent therapeutic advances, achieving optimal glycaemic control remains a challenge in managing Type 2 Diabetes (T2D). Sodium-glucose co-transporter type (SGLT2) inhibitors have emerged as effective treatments by promoting urinary glucose excretion. However, the full scope of their mechanisms extends beyond control. At present, immunometabolic effects remain elusive. To investigate SGLT2 inhibition or deletion, we compared metabolic and immune phenotype between high fat diet-fed control, chronically dapagliflozin-treated mice total-body SGLT2/ Slc5a2 knockout mice. null exhibited superior tolerance insulin sensitivity to mice, independent glycosuria body weight. Moreover, demonstrated physiological regulation corticosterone secretion, with lowered morning levels Systemic cytokine profiling also unveiled significant alterations inflammatory mediators, particularly interleukin 6 (IL-6). Furthermore, unbiased proteomic analysis downregulation acute-phase proteins upregulation glutathione-related proteins, suggesting role modulation antioxidant responses. Conversely, IL-6 increased expression kidney HK2 cells for cytokines hyperglycemia. Collectively, our study elucidates potential interplay activity, modulation, homeostasis. Graphical Article Highlights The immunity elusive, despite extensive research inhibitors. We sought discern deletion on profiles high-fat-fed focussing alterations. exhibit enhanced sensitivity, alongside physiologically regulated cytokines, identified changes protein suggestive modulation. Our findings emphasize responses mediated activity.
Язык: Английский
Процитировано
1
Biomedical Reports, Год журнала: 2024, Номер 22(1)
Опубликована: Окт. 29, 2024
The prevalence of type 2 diabetes mellitus (T2DM) is steadily increasing worldwide in an alarming fashion. Importantly, poor glycemic control associated with development various health sequalae's due to glucolipotoxicity, oxidative stress and increased inflammatory cytokines. aim the present study was examine effect on relative abundance markers patients controlled uncontrolled T2DM, test their association status diabetic Jordan. An observational cross-sectional design used. Patients T2DM [glycated hemoglobin (HbA
Язык: Английский
Процитировано
1
Rheumatology Science and Practice, Год журнала: 2024, Номер 62(2), С. 135 - 144
Опубликована: Апрель 28, 2024
Glucagon-like peptide-1 receptor agonists (ArGLP-1) are effective drugs for the treatment of type 2 diabetes mellitus and obesity. Recent studies in patients with a wide range immunoinflammatory diseases suggest important pleiotropic mechanisms action these drugs, primarily related to suppression inflammation. The article presents new data indicating prospects use ArGLP-1 rheumatic diseases, which dictates need clinical studies. GLP-1 immune-mediated
Язык: Английский
Процитировано
0
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Май 22, 2024
Abstract Background The integration of large language models (LLMs) such as GPT-4 into healthcare presents potential benefits and challenges. While LLMs have shown promise in applications ranging from scientific writing to personalized medicine, their practical utility safety clinical settings remain under scrutiny. Concerns about accuracy, ethical considerations bias necessitate rigorous evaluation these technologies against established medical standards. Objective To compare the completeness, necessity, dosage accuracy overall type 2 diabetes management plans created by with those devised experts. Methods This study involved a comparative analysis using anonymized patient records setting West Bengal, India. Management for 50 Type patients were generated three blinded These evaluated reference plan based on American Diabetes Society guidelines. Completeness, necessity quantified an error score was assess quality plans. also assessed. Results indicated that experts’ had fewer missing medications compared (p=0.008). However, included unnecessary (p=0.003). No significant difference observed drug dosages (p=0.975). scores comparable between human experts (p=0.301). Safety issues noted 16% GPT-4, highlighting risks associated AI-generated Conclusion demonstrates while can effectively reduce prescriptions, it does not yet match performance terms completeness safety. findings support use supplementary tools healthcare, underscoring need enhanced algorithms continuous oversight ensure efficacy AI settings. Further research is necessary improve complex environments.
Язык: Английский
Процитировано
0