Impact of Pharmacogenomics in Clinical Practice
Pharmaceuticals,
Год журнала:
2023,
Номер
16(11), С. 1596 - 1596
Опубликована: Ноя. 13, 2023
Polymorphisms
of
genes
encoding
drug
metabolizing
enzymes
and
transporters
can
significantly
modify
pharmacokinetics,
this
be
associated
with
significant
differences
in
efficacy,
safety,
tolerability.
Moreover,
genetic
variants
some
components
the
immune
system
explain
clinically
relevant
drug-related
adverse
events.
However,
implementation
dose
individualization
based
on
pharmacogenomics
remains
scarce.
In
narrative
review,
impact
variations
disposition,
tolerability
most
commonly
prescribed
drugs
is
reported.
reasons
for
poor
everyday
clinical
settings
are
discussed.
The
literature
analysis
showed
that
knowledge
how
effectiveness,
a
lead
to
adjustment
usually
recommended
dosages,
improve
reduce
Despite
efforts
introduce
practice,
presently
very
few
centers
routinely
use
tests
as
guide
prescription.
education
health
care
professionals
seems
critical
keep
pace
rapidly
evolving
field
pharmacogenomics.
multimodal
algorithms
incorporate
both
factors
prescribing
could
help
regard.
Obviously,
further
studies
which
definitively
establish
play
role
conditioning
effectiveness
safety
needed.
Many
problems
must
solved,
but
advantages
human
fully
justify
all
efforts.
Язык: Английский
Public preferences for pharmacogenetic testing in the NHS: Embedding a discrete choice experiment within service design to better meet user needs
British Journal of Clinical Pharmacology,
Год журнала:
2024,
Номер
90(7), С. 1699 - 1710
Опубликована: Апрель 14, 2024
Genetic
testing
can
be
used
to
improve
the
safety
and
effectiveness
of
commonly
prescribed
medicines-a
concept
known
as
pharmacogenetics.
This
study
aimed
quantify
members
UK
public's
preferences
for
a
pharmacogenetic
service
delivered
in
primary
care
National
Health
Service.
Язык: Английский
Associação da farmacogenômica com farmacogenes da superfamília citocromo P450 e os desafios de implementação na prática clínica
Brazilian Journal of Health Review,
Год журнала:
2024,
Номер
7(4), С. e71406 - e71406
Опубликована: Июль 23, 2024
A
farmacogenômica
representa
um
dos
importantes
pilares
da
medicina
de
precisão.
Mutações
em
genes
superfamília
cytochrome
P450
tem
sido
associadas
com
alteração
na
farmacocinética.
Apesar
relevância
farmacogenômica,
a
implementação
prática
clínica
ainda
desafio.
Nesse
contexto,
o
objetivo
do
presente
artigo
foi
investigar
relação
entre
e
citocromo
P450.
Além
desafios
clínica.
Foi
realizada
uma
revisão
narrativa
literatura
partir
artigos
científicos
disponíveis
base
dados
pubmed
publicados
2003
2023.
Os
família
oxidase
estão
envolvidos
metabolização
70-80%
principais
medicamentos
utilizados.
O
farmacogene
CYP2D6
possui
grande
clínica,
vez
que
é
responsável
por
metabolizar
variedade
substratos
incluindo
analgésicos,
antidepressivos,
anti-hipertensivos
agentes
anticancerígenos.
miRNAs
padrão
expressão
gênica
membros
Dados
projeto
Ubiquitous
Pharmacogenomics
demonstraram
pacientes
resultados
quando
tratados
acordo
as
recomendações
clínicas
apresentaram
menor
porcentagem
reações
adversas.
Contudo,
apesar
das
evidências
positivas,
desafio,
especialmente
países
desenvolvimento.
inegável
importância
desenvolvimento
científico,
qual
pode
contribuir
para
futuro
próximo
se
torne
realidade
dentro
Severe toxicities in amazonian populations and the role of precision medicine in acute lymphoblastic leukemia treatment
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Ноя. 26, 2024
Abstract
Corticosteroids,
such
as
prednisone
or
dexamethasone,
constitute
integral
components
of
antineoplastic
regimens
for
Acute
Lymphoblastic
Leukemia
(ALL)
therapy,
albeit
accompanied
by
significant
adverse
effects.
The
multifactorial
nature
interindividual
variability
in
drug
response,
encompassing
genetic
polymorphisms,
underscores
the
complexity
pharmacotherapy
outcomes.
However,
pharmacogenetic
investigations
hitherto
have
predominantly
focused
on
cohorts
European
and
North
American
descent,
thus
limiting
generalizability
findings
to
populations
with
minimal
representation.
Indigenous
Brazil,
particularly
those
inhabiting
Amazon
region,
exhibit
a
distinctive
heritage,
characterized
Native
ancestry.
These
frequently
manifest
suboptimal
therapeutic
responses
elevated
mortality
rates
following
ALL
treatment.
Therefore,
delineating
molecular
signatures
genes
implicated
corticosteroid
pathway
within
these
indigenous
assumes
paramount
importance.
This
study
identified
novel
variants
associated
glucocorticoid
Amazonian
conducted
comparative
analyses
variant
frequencies
across
diverse
global
populations.
underscore
uniqueness
groups
highlight
potential
impact
factors
Precision
medicine
approaches
tailored
peculiarities
emerge
imperative
strategies
optimizing
efficacy
mitigating
treatment-related
toxicities
communities.
Язык: Английский