The Breathomics Profile of Volatile Sulfur Compounds in the Bipolar Spectrum, Does It Represent a Potential Tool for Early Diagnosis?

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(6), С. 2025 - 2025

Опубликована: Март 17, 2025

Background/Objectives: Emerging laboratory technologies, such as breathomics, may enhance the early diagnosis of psychiatric disorders, including Bipolar Disorder (BD). This study investigates detection volatile sulfur compounds (VSCs) in exhaled breath potential biomarkers for BD, comparing VSC levels between individuals with healthy controls, and non-pathological hyperactivity. Methods: A matched case–control was conducted involving 24 patients BD 95 controls recruited at University Hospital Cagliari. Controls were selected using a matched-pair design based on age (±5 years) sex through block-matching technique to ensure comparability cases. Participants underwent interviews, completed Mood Questionnaire (MDQ), had their breaths analyzed VSCs gas chromatograph (OralChroma™). randomized sex. Results: Patients exhibited significantly higher methyl mercaptan (CH3SH) compared (18.62 ± 5.04 vs. 9.45 18.64 ppb, p = 0.022). Among without those positive MDQ scores showed lower CH3SH than negative (9.17 5.42 15.05 18.03); however, this difference did not reach statistical significance (p 0.254), highlighting how deep connection some clinical aspects needs be investigated more thoroughly. Conclusions: The results suggest correlation oral dysbiosis metabolic alterations being cases controls. Further studies are needed validate use investigate role

Язык: Английский

Adaptive Hyperactivity and Biomarker Exploration: Insights from Elders in the Blue Zone of Sardinia

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(21), С. 6451 - 6451

Опубликована: Окт. 28, 2024

Background/Objectives: Adaptive hyperactivity characterized by increased activity levels and novelty-seeking traits without mood disorders is prevalent among older adults in Sardinia’s “blue zone,” an area with high longevity. This study aims to evaluate the adaptive nature of concerning quality life, social rhythms, symptoms individuals from this region, particularly elderly over 80. Methods: observational cross-sectional included 80 blue zone. a sample patients followed at Center for Consultation Psychiatry Psychosomatics Bipolar Disorder University Hospital Cagliari homogeneous comparison psychiatric pathologies, referred Dermatology Clinic same hospital, period 6 months, February August 2024. The general sample, divided into two parts—cases, represented pathology, controls, pathology—was turn three sub-groups: “adults” (18–64 years), young elders (65–79), old (over years). participants underwent interviews completed Mood Questionnaire (MDQ), Patient Health (PHQ-9), SF-12, Brief Social Rhythm Scale (BSRS). Data were compared national regional normative data. Results: Older zone demonstrated higher MDQ positivity (22.58%) averages (0.87%), corresponding increases dysregulated depressive symptoms, or reduced life. Younger persons (65–79 years) showed rhythm dysregulation (BSRS score: 20.64 ± 7.02) (17.40 6.09, p = 0.040), but trend was not observed oldest group (80+ No significant differences found CH3SH (CH3)2S between groups. Conclusions: appears linked dysregulation, diminished suggesting resilience factors which may contribute These findings support potential classification such as beneficial rather than pathological, warranting further research biomarkers psychoeducational interventions prevent onset bipolar predisposed individuals.

Язык: Английский