Multiple pathways through which the gut microbiota regulates neuronal mitochondria constitute another possible direction for depression DOI Creative Commons
Hongyi Zhao, Xiu Qiu, Shuyu Wang

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

As a significant mental health disorder worldwide, the treatment of depression has long faced challenges low rate, drug side effects and high relapse rate. Recent studies have revealed that gut microbiota neuronal mitochondrial dysfunction play central roles in pathogenesis depression: influences course through multiple pathways, including immune regulation, HPA axis modulation neurotransmitter metabolism. Mitochondrial function serves as key hub mediates mood disorders mechanisms such defective energy metabolism, impaired neuroplasticity amplified neuroinflammation. Notably, bidirectional regulatory network exists between mitochondria: flora metabolite butyrate enhances biosynthesis activation AMPK–PGC1α pathway, whereas reactive oxygen species produced by mitochondria counteract composition altering intestinal epithelial microenvironment. In this study, we systematically potential pathways which improves regulating synthesis, autophagy, oxidative stress homeostasis proposed integration probiotic supplementation, dietary fiber intervention, fecal microbial transplantation to remodel flora–mitochondrial axis, provides theoretical basis for development novel antidepressant therapies targeting gut–brain interactions.

Язык: Английский

The role of short-chain fatty acid in metabolic syndrome and its complications: focusing on immunity and inflammation DOI Creative Commons
Wenqian Yu,

Siyuan Sun,

Qiang Fu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 7, 2025

Metabolic syndrome (Mets) is an important contributor to morbidity and mortality in cardiovascular, liver, neurological, reproductive diseases. Short-chain fatty acid (SCFA), organismal energy donor, has recently been demonstrated increasing number of studies be molecule ameliorating immuno-inflammation, causative factor Mets, improve lipid distribution, blood glucose, body weight levels animal models Mets. This study reviews recent research advances on SCFA Mets from immune-inflammatory perspective, including complications dominated by chronic inflammation, as well the fact that these findings also contribute understanding specific mechanisms which gut flora metabolites metabolic processes humans. review proposes emerging role for inflammatory followed identification major ambiguities further understand anti-inflammatory potential this substance In addition, novel strategies modulate treatment may help mitigate prognosis its complications.

Язык: Английский

Процитировано

3
Limosilactobacillus reuteri fermented brown rice alleviates anxiety improves cognition and modulates gut microbiota in stressed mice DOI Creative Commons
Akanksha Tyagi,

Yu-Yeong Choi,

Lingyue Shan

и другие.

npj Science of Food, Год журнала: 2025, Номер 9(1)

Опубликована: Янв. 11, 2025

Chronic stress disrupts gut microbiota homeostasis, contributing to anxiety and depression. This study explored the effects of Limosilactobacillus reuteri fermented brown rice (FBR) on using an ICR mouse chronic mild (CMS) model. Anxiety was assessed through body weight, corticosterone levels, neurotransmitter profiles, behavioral tests. A four-week FBR regimen reduced corticosterone, restored neurotransmitters like gamma-aminobutyric acid (GABA) serotonin, improved anxiety-related behaviors. Metagenomic (16S rRNA) metabolomic analyses revealed enhanced amino metabolism, energy short-chain fatty (SCFA) production in FBR-treated mice. FBR-enriched beneficial bacteria, aligning profile with that non-stressed also modulated GABA receptor-related gene expression, promoting relaxation. Network pharmacology identified quercetin, GABA, glutamic acid, phenylalanine, ferulic as bioactive compounds neuroprotective potential. These findings highlight FBR's potential a gut-brain axis-targeted therapeutic for stress-related disorders.

Язык: Английский

Процитировано

2
Role of gut microbiota in regulating immune checkpoint inhibitor therapy for glioblastoma DOI Creative Commons
Hao Zhang,

Ying Hong,

Tingting Wu

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 10, 2024

Glioblastoma (GBM) is a highly malignant, invasive, and poorly prognosed brain tumor. Unfortunately, active comprehensive treatment does not significantly prolong patient survival. With the deepening of research, it has been found that gut microbiota plays certain role in GBM, can directly or indirectly affect efficacy immune checkpoint inhibitors (ICIs) various ways. (1) The metabolites produced by host’s homeostasis, these function distribution cells, promote inhibit inflammatory responses, phenotype, angiogenesis, response, cell infiltration GBM thereby affecting effectiveness ICIs. (2) Some members may reverse T inhibition, increase anti-tumor activity, ultimately improve ICIs targeting specific immunosuppressive cytokines. (3) participate metabolic process drugs, which degrade, transform, produce metabolites, effective concentration bioavailability drugs. Optimizing structure help (4) also regulate status through axis communication, progression therapeutic response to (5) Given importance for ICI therapy, researchers have begun exploring use fecal transplantation (FMT) transplant healthy optimized patients, order their enhance therapy. Preliminary studies suggest FMT therapy some patients. In summary, crucial regulating with deeper understanding relationship between tumor immunity, expected develop more precise personalized strategies prognosis.

Язык: Английский

Процитировано

10
Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomedicines, Год журнала: 2025, Номер 13(2), С. 422 - 422

Опубликована: Фев. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Язык: Английский

Процитировано

1
Therapeutic Role of Inulin in Disease Management DOI
Anchala Guglani,

S Shukla,

Ravi Tripathi

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
A shotgun metagenomic study identified short-chain fatty acid-producing species and their functions in the gut microbiome of adults with depressive symptoms: Large-scale shotgun sequencing data of the gut microbiota using a cross-sectional design DOI
Sunyoung Kim, So‐Youn Woo, Hyung‐Lae Kim

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер 376, С. 26 - 35

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

0
Acetate and propionate vs. iTBS as a novel method for cognitive dysfunction and anxiety symptoms in delayed encephalopathy after acute carbon monoxide poisoning rat DOI Creative Commons

Tianyu Meng,

Xin Zhang, Jili Zhao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 26, 2025

The optimal treatment methods for delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP) were not identified. Thus, this study was conducted to compare the efficacies of intermittent theta burst stimulation (iTBS) and short-chain fatty acids (SCFAs) in treating cognitive dysfunction anxiety symptoms DEACMP rat. In phase I, a rat model built assess inflammation levels hippocampus SCFAs serum rats. II, rats randomly assigned into four groups: + placebo, SCFAs, sham iTBS, iTBS. intervention continued 2 weeks. A Morris water maze open field tests used function symptoms, respectively. three inflammatory factors (IL-1β, IL-6, TNF-α) two (acetate propionate) significantly increased decreased, respectively, After treatment, improved iTBS group (consisting acetate group. Both could improve IL-1β, TNF-α hippocampus, also decreased GPR41, GPR43, dopamine, norepinephrine These results indicate that both SCFA solutions consisting propionate produced good effects on by regulating acetate/propionate-GPR41/GPR43-IL-1β/IL-6/TNF-α-dopamine/norepinephrine may be potential pathway DEACMP.

Язык: Английский

Процитировано

0
The Modulatory Role of Bioactive Compounds in Functional Foods on Inflammation and Metabolic Pathways in Chronic Diseases DOI Creative Commons
Zheng Feei, Caili Fu, Yeong Yeh Lee

и другие.

Foods, Год журнала: 2025, Номер 14(5), С. 821 - 821

Опубликована: Фев. 27, 2025

Chronic diseases are major contributors to global morbidity and mortality. More than 70% of deaths worldwide caused by chronic diseases, including cardiovascular (CVDs), obesity, type 2 diabetes, cancer. These characterised low-grade inflammation metabolic dysregulation. Incorporating functional foods into daily diet has been suggested as a complementary strategy promote health lower the risk non-communicable diseases. Functional foods, known that confer benefits beyond basic nutrition, have reported exhibit preventive therapeutic such anti-inflammatory properties for human health. Therefore, aim this state-of-the-art review will synthesise findings from recent high-quality studies investigated modulatory role some commonly bioactive active compounds, polyphenols, omega-3 fatty acids, probiotics, prebiotics, in pathways.

Язык: Английский

Процитировано

0
Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label study DOI Creative Commons
Riko Mishima, Ryuta Ejima, Satoshi Arai

и другие.

Gut Microbes Reports, Год журнала: 2025, Номер 2(1)

Опубликована: Апрель 10, 2025

Язык: Английский

Процитировано

0
Gut microbiome and schizophrenia: insights from two-sample Mendelian randomization DOI Creative Commons

Keer Zhou,

Ancha Baranova, Hongbao Cao

и другие.

Schizophrenia, Год журнала: 2024, Номер 10(1)

Опубликована: Сен. 2, 2024

Growing evidence suggests a potential link between the gut microbiome and schizophrenia. However, it is unclear whether causally associated with We performed two-sample bidirectional Mendelian randomization to detect causal relationships Summary genome-wide association study (GWAS) datasets of from MiBioGen consortium (n = 18,340) schizophrenia 130,644) were utilized in our study. Then cohort sensitive analyses was followed validate robustness MR results. identified nine taxa that exerted positive effects on (OR: 1.08–1.16) six conferred negative 0.88–0.94). On other hand, reverse analysis showed may increase abundance 1.03–1.08) reduce two 0.94). Our unveiled mutual The findings provide for treatment microbiomes

Язык: Английский

Процитировано

4