Results in Chemistry, Год журнала: 2024, Номер 12, С. 101892 - 101892
Опубликована: Ноя. 9, 2024
Язык: Английский
Therapeutic Advances in Gastroenterology, Год журнала: 2025, Номер 18
Опубликована: Янв. 1, 2025
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is characterized by chronic nonspecific intestinal inflammation. Despite considerable efforts, IBD remains a heavy burden on society human health, with increasing morbidity. Posttranslational modification, especially histone acetylation, key process in controlling DNA transcriptional activity. Histone deacetylases (HDACs) play vital role the mechanism of pathogenesis through nonhistone protein deacetylation. Herein, we present summary different categories HDACs as well HDAC inhibitors (HDACis) analyze inhibition alleviating along its mechanism, clinical potential HDACis treatment.
Язык: Английский
Процитировано
0
Exploration of Immunology, Год журнала: 2025, Номер 5
Опубликована: Март 4, 2025
In hematological malignancies, autologous immunotherapy with T lymphocytes expressing a chimeric antigen receptor (CAR-T) has been successfully applied. CAR enhances the immuno-cellular effector system directly against cells target antigens. The objective here was to discuss prospects of applying CAR-T and its variants in autoimmune diseases (AIDs) deplete pathogenic autoantibodies by eliminating B plasma cells. play crucial role pathogenesis AID through production autoantibodies, cytokine dysregulation, presentation, regulatory dysfunction. numerous autoreactive clones various autoantigens, such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis, myositis, sclerosis, targeting CD19/CD20 B-cell maturation (BCMA) have shown success preclinical clinical studies, representing an innovative option for refractory patients when standard treatments fail. suppression reactive specific antigens using cytolytic carrying autoantibody (CAAR-T) offers promising approach managing AIDs, especially those characterized pemphigus vulgaris, myasthenia gravis, anti-NMDAR encephalitis. CAAR-T allows elimination without compromising general functionality immune system, minimizing common side effects immunosuppressive therapies, including immunobiologicals CAR-T. vitro, preclinical, (phase 1) studies demonstrated efficacy specificity several AIDs; however, extensive trials 3) are required assess their safety applicability. These advances promise enhance precision medicine management offering personalized individual patients.
Язык: Английский
Процитировано
0
European Cardiology Review, Год журнала: 2025, Номер 20
Опубликована: Апрель 1, 2025
Background: This study investigates the causal relationships between 731 immune cell traits and aortic dissection (AD) using Mendelian randomisation (MR). By identifying specific phenotypes contributing to AD, we explore their clinical implications for risk stratification therapeutic interventions. Methods: A bivariate MR framework analysed dynamics attributes genetic variants as instrumental variables. Summary statistics from a genome-wide association were obtained. Univariable analysis was conducted inverse-variance weighted method supplemented by sensitivity analyses. Horizontal pleiotropy assessed MR-Egger residual sum outlier. Significant cis-expression quantitative trait loci (eQTL) identified via Genotype-Tissue Expression (GTEx) database, followed tissue-specific expression pathway Results: Four immunophenotypes exhibited positive effects on while one showed negative effect. Pathogenic included median fluorescence intensity of CD19 transitional B cells, immunoglobulin D- CD38dim CD3 CD39+ CD4+ Treg activated cells. The protective absolute count CD86+ myeloid dendritic Sensitivity analyses validated these associations. Pathway enrichment highlighted significant arterial enrichments key biological processes, SLAMF6 CD28 genes. Conclusion: suggests potential roles in AD pathogenesis, although findings should be interpreted with caution due limitations. types associated eQTL genes offer promising targets Future research focus translating into practical strategies patient care.
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 155, С. 114624 - 114624
Опубликована: Апрель 10, 2025
Regulatory T cells (Tregs) are a specialized subset of suppressive that essential for maintaining self-tolerance, regulating effector cells, managing microbial infections, preventing tumors, allergies, and autoimmune disorders, facilitating allograft transplantation. Disruptions in Treg function or abundance contribute to an imbalance between pathogenic protective immune diseases. Recently, one promising treatment strategy restore balance involves the selective expansion manipulation Tregs using low-dose IL-2 therapy, adoptive cell transfer, chimeric antigen receptor (CAR)-Treg approaches. have been shown increasing number research studies prevent even treat variety such as allergic diseases, transplant rejection, graft-versus-host disease. A thorough comprehension is anticipated provide clear prospects effective immunotherapy wide range This review provides overview biology, including their functions, mechanisms, phenotypic markers, well involvement disease settings. Furthermore, we discuss therapeutic potential different subpopulations translational applications
Язык: Английский
Процитировано
0
Clinical and Translational Medicine, Год журнала: 2025, Номер 15(4)
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Дек. 4, 2024
Autoimmune diseases, characterized by the immune system's attack on body's own tissues, affect millions of people worldwide. Current treatments, which primarily rely broad immunosuppression and symptom management, are often associated with significant adverse effects necessitate lifelong therapy. This review explores next generation therapies for immune-mediated including chimeric antigen receptor (CAR) T cell regulatory (Treg)-based approaches, offer prospect targeted, durable disease remission. Notably, we highlight emergence CD19-targeted CAR therapies, their ability to drive sustained remission in B cell-mediated autoimmune suggesting a possible paradigm shift. Further, discuss therapeutic potential Type 1 FOXP3
Язык: Английский
Процитировано
1
Journal of Crohn s and Colitis, Год журнала: 2024, Номер unknown
Опубликована: Окт. 21, 2024
Язык: Английский
Процитировано
0
Results in Chemistry, Год журнала: 2024, Номер 12, С. 101892 - 101892
Опубликована: Ноя. 9, 2024
Язык: Английский
Процитировано
0