Alcohol–Related Liver Disease, Followed by Metabolic Dysfunction–Associated Steatotic Liver Disease, Emerges as the Fastest‐Growing Aetiologies for Primary Liver Cancer in the United States

Alimentary Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 5, 2025

ABSTRACT Objective Primary liver cancer (PLC) is projected to be the third leading cause of mortality in United States 2040. We examine burden PLC States, stratified by sex, state and aetiological risk factors. Methods Data on prevalence, incidence, death disability–adjusted life years (DALYs) were extracted from Global Burden Disease Study 2021. Changes these parameters calculated using Joinpoint regression model. Results There 47,970 cases, 31,450 incident 24,770 deaths 576,920 DALYs States. The highest prevalence (16,980), incidence (12,040), (9840) (213,410) due chronic hepatitis C virus infection. From 2000 2021, incidences increased 141%, 136%. Age–standardised rates (ASIRs) (ASDRs) per 100,000 population for increased, primarily driven alcohol–related disease (ALD) (ASIR: annual percent change [APC]: +2.40%; ASDR: APC: +2.22%) metabolic dysfunction–associated steatotic (MASLD) +2.32%; +2.04%). Conclusion has risen past two decades, mainly ALD followed MASLD. These findings offer policymakers an accurate assessment emphasise need targeted factor mitigation, especially regarding alcohol related policy.

Язык: Английский

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Global Burden, Trends, and Inequalities of Gallbladder and Biliary Tract Cancer, 1990–2021: A Decomposition and Age–Period–Cohort Analysis

Liver International, Год журнала: 2025, Номер 45(2)

Опубликована: Янв. 1, 2025

ABSTRACT Background Gallbladder and biliary tract cancer (GBTC) increasingly aggravates the global malignancy burden. This study aimed to evaluate updated condition of GBTC temporal burden trends inequalities from 1990 2021. Methods Data on were extracted Global Burden Disease (GBD) 2021 study. Incidence, deaths, disability‐adjusted life years (DALYs) their age‐standardised rates (ASR) quantified 2021, stratified by sex, age sociodemographic index (SDI). The age–period–cohort (APC) model was used elucidate effects age, period, cohort. Decomposition analysis cross‐country inequality evaluation performed assess contributing factors disease imbalance, respectively. Bayesian APC estimate future Results In incident cases 216 768, with 171 961 deaths 3 732 121 DALYs lost. From ASR incidence, mortality, decreased slightly. Males showed a slight increase in while females experienced significant decrease. High‐income regions, particularly Asia Pacific Latin America, exhibited higher burden, Western Sub‐Saharan Africa had lowest. Low low‐middle SDI regions gradual rise all metrics despite lower absolute numbers. indicated that incidence tended but gender differences existed. Besides, deteriorating cohort effect detected amongst individuals born between 1907 1917. revealed population growth primary driver increased globally. Significant disparities observed, notable decline over time. Projections slow through 2040, more pronounced decrease females. Conclusions There are regional GBTC. Population remains major contributor Despite overall decline, increasing low lower‐middle persistent male highlight need for targeted interventions. Future efforts should focus addressing socio‐economic reducing risk factors, vulnerable populations.

Язык: Английский

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Increased MASH-associated liver cancer in younger demographics

Hepatology Communications, Год журнала: 2025, Номер 9(1)

Опубликована: Янв. 1, 2025

Background: The incidence of cancer and the prevalence metabolic disease dysfunction–associated steatotic liver is increasing in young adults. However, updated global data on steatohepatitis (MASH)-associated primary (PLC) adults remains scarce. Methods: This study analyzed from Global Burden Disease between 2000 2021 to assess age-standardized incidence, mortality, disability-adjusted life years rates MASH-associated PLC (15–49 y). Results: In 2021, there were 4300 cases, 3550 deaths, 179,340 Among various etiologies adults, only had increased (annual percent change: +0.26, 95% CI: 0.16%–0.35%), with Eastern Mediterranean region having largest observed increase 1.46%, 1.40%–1.51%). made up 6% (+1% 2000) incident (+2% all this age group. Over half countries exhibited an rate 2021. Conclusions: significantly increasing, signaling likely future increases among older as cohort ages. trend necessitates urgent strategies worldwide mitigate epidemics

Язык: Английский

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Older adults living with gastrointestinal cancers in 2021

Cancer Communications, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Язык: Английский

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Hepatocellular carcinoma: updates on epidemiology, surveillance, diagnosis and treatment

Clinical and Molecular Hepatology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Hepatocellular carcinoma (HCC) is a major global burden, ranking as the third leading cause of cancer-related mortality.HCC due to chronic hepatitis B virus (HBV) or C (HCV) infection has decreased universal vaccination for HBV and effective antiviral therapy both HCV, but HCC related metabolic dysfunction associated steatotic liver disease (MASLD) alcohol-associated (ALD) increasing.Biannual ultrasonography serum α-fetoprotein are primary surveillance tools early detection among high-risk patients (e.g., cirrhosis, HBV).Alternative such blood-based biomarker panels abbreviated MRIs being investigated.Multiphasic CT MRI standard diagnosis, histological confirmation should be considered, especially when inconclusive findings seen on cross-sectional imaging.Staging treatment decisions complex made in multidisciplinary settings, incorporating multiple factors including tumor degree dysfunction, patient performance status, available expertise, preferences.Early-stage best treated with curative options resection, ablation, transplantation.For intermediatestage disease, locoregional therapies primarily recommended although systemic may preferred large intrahepatic burden.In advanced-stage immune checkpoint inhibitor (ICI)-based regimen.In this review article, we discuss recent epidemiology, risk factors, care continuum encompassing surveillance, staging, treatments.

Язык: Английский

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Epidemiological trends in gastrointestinal cancers and risk factors across U.S. states from 2000 to 2021: a systematic analysis for the global burden of disease study 2021

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 6, 2025

Gastrointestinal (GI) cancers account for over a quarter of all cancer-related deaths in the United States; however, latest trends their prevalence remain unclear. Data on GI were obtained from Global Burden Disease Study 2021. Age-standardized incidence rates (ASIR) and age-standardized mortality (ASMR) estimated across various states, sexes, ages, risk factors, annual percentage changes calculated. From 2000 to 2021, liver cancer exhibited greatest increase both ASIR ASMR, followed by pancreatic cancer. In contrast, stomach showed decline, colorectal cancer, esophageal biliary tract Most predominantly affect men tend toward younger age onset. Geographic disparities exist burden factors. For esophageal, stomach, cancers, linked diet smoking decreased, whereas alcohol-related increased several especially West Virginia. Hepatitis C remains leading cause with intravenous drug use as primary factor. Non-alcoholic steatohepatitis (NASH) is fastest-growing excessive alcohol use. Mortality due high body-mass index fasting plasma glucose have states groups. The epidemiological U.S. shifted substantially. States need implement targeted policies that address specific populations factors each type.

Язык: Английский

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Neoplastic premalignant pancreatobiliary lesions: current update on the spectrum of lesions and their imaging appearances

Abdominal Radiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Язык: Английский

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Temporal Trends in Stomach and Colorectal Cancer Mortality by Racial Groups in Brazil (2000–2023): A Longitudinal Ecological Study

International Journal of Environmental Research and Public Health, Год журнала: 2025, Номер 22(2), С. 208 - 208

Опубликована: Янв. 31, 2025

This longitudinal ecological study analyzed racial disparities in mortality trends for stomach cancer (SC) and colorectal (CRC) Brazil (2000 to 2023) stratified by sex. Data from the National Mortality Information System were individuals aged 25 80. Self-reported race/skin color followed Brazilian Institute of Geography Statistics classification: White (White group) Black or Brown/multiracial (Black group). Age-standardized rates used world population as a reference, Prais-Winsten autoregression calculated trends. SC declined both sexes groups, with greater reduction Annual Percent Change (APC) among Whiteindividuals. Conversely, CRC increased, group showing higher percentage increase APC. Despite progress reducing mortality, persist, particularly CRC, where populations experience worse outcomes. Higher observed individuals, but highlight growing burden populations. These findings emphasize urgent need address outcomes, they remain critical public health challenge despite advancements healthcare access disease control Brazil.

Язык: Английский

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Global health inequalities in the burden of gastrointestinal cancers from 1990 to 2021

Gut, Год журнала: 2025, Номер unknown, С. gutjnl - 334802

Опубликована: Фев. 11, 2025

Язык: Английский

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Early-Onset Gastrointestinal Cancers and Metabolic Risk Factors: Global Trends From the Global Burden of Disease Study 2021

Mayo Clinic Proceedings, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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