SENECA study: staging endometrial cancer based on molecular classification

International Journal of Gynecological Cancer, Год журнала: 2024, Номер 34(9), С. 1313 - 1321

Опубликована: Авг. 17, 2024

Management of endometrial cancer is advancing, with accurate staging crucial for guiding treatment decisions. Understanding sentinel lymph node (SLN) involvement rates across molecular subgroups essential. To evaluate SLN in early-stage (International Federation Gynecology and Obstetrics 2009 I-II) cancer, considering subtypes new European Society Gynaecological Oncology (ESGO) risk classification. The SENECA study retrospectively reviewed data from 2139 women stage I-II 66 centers 16 countries. Patients underwent surgery assessment following ESGO guidelines between January 2021 December 2022. Molecular analysis was performed on pre-operative biopsies or hysterectomy specimens. Among the patients, were as follows: 272 (12.7%) p53 abnormal (p53abn, 1191 (55.7%) non-specific profile (NSMP), 581 (27.2%) mismatch repair deficient (MMRd), 95 (4.4%) POLE mutated (POLE-mut). Tracer diffusion detected in, at least one side, 97.2% cases; a bilateral observed 82.7% cases. By ultrastaging (90.7% cases) one-step nucleic acid amplification (198 (9.3%) cases), 205 patients identified affected nodes, representing 9.6% sample. Of these, 139 (67.8%) had low-volume metastases (including micrometastases, 42.9%; isolated tumor cells, 24.9%) while (32.2%) macrometastases. Significant differences subtypes, p53abn MMRd groups having highest (12.50% 12.40%, respectively) compared NSMP (7.80%) POLE-mut (6.30%), (p=0.004); OR=1.69 (95% CI 1.11 to 2.56), p=0.014; MMRd, OR=1.67 1.21 2.31), p=0.002). Differences also noted among (2.84% low-risk 6.62% intermediate-risk 21.63% high-intermediate 22.51% high-risk patients; p<0.001). Our reveals significant based subtypes. This underscores importance characteristics optimal management

Язык: Английский

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SLYMEC II study: overall survival analysis of the impact of LVSI in apparent early stage endometrioid endometrial cancer.

European Journal of Surgical Oncology, Год журнала: 2025, Номер unknown, С. 109750 - 109750

Опубликована: Март 1, 2025

Язык: Английский

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Safety of minimally invasive surgery in early-stage endometrial cancer: a systematic Retrospective analysis based on 2023 FIGO staging system

European Journal of Surgical Oncology, Год журнала: 2025, Номер unknown, С. 109997 - 109997

Опубликована: Март 1, 2025

Язык: Английский

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External validation of CEA and CA125 prediction model for lymph node metastasis in endometrial cancer: A multi-institute cohort study

Cancer Biomarkers, Год журнала: 2025, Номер 42(3)

Опубликована: Март 1, 2025

Background We previously utilized pretreatment tumor markers Carcinoembryonic Antigen (CEA) and Cancer 125 (CA125) for predicting lymph node metastasis (LNM) in endometrioid endometrial cancer (EC). Objective The aim of this study was to externally validate a nomogram developed our previous single-center retrospective study. Methods A multi-center validation conducted recruit EC patients from four branches Chang Gung Memorial Hospital between 2009 2021, with participating the original research being excluded. established applied optimal cut-off values CEA 1.4 ng/ml CA125 40 U/mL identified through receiver operating characteristic (ROC) curves. concordance index (C-index) calculated assess discrimination, comparative negative predictive value (NPV) likelihood ratio (NLR) were determined. Decision curve analysis (DCA) plotted evaluate model's clinical utility net benefit. Results Overall, 1271 included external results demonstrated C-index 0.727, indicating moderate discrimination ability LNM independent cohort. Comparative NPV 97.2% NLR 0.36 revealed performance metrics consistent study, reinforcing nomogram's potential ruling out possibility if both less than U/mL, respectively. DCA indicated that provided utility. Conclusion reproducible large sample cohort underscore robustness generalizability utilizing as predictors EC, suggesting its simple tool clinicians preoperative decision-making regarding lymphadenectomy.

Язык: Английский

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The detection rate of metastatic lymph nodes comparing sentinel lymph node biopsy and lymphadenectomy for staging of intermediate- and high-risk endometrial carcinoma

International Journal of Gynecological Cancer, Год журнала: 2025, Номер unknown, С. 101810 - 101810

Опубликована: Апрель 1, 2025

The primary aim of this study was to compare the detection rates nodal metastases between lymphadenectomy (LND) and sentinel lymph node (SLN) in intermediate- high-risk patients with assumed uterine-confined disease. This a single-center observational from tertiary referral center (2006-2023). Intermediate risk defined as endometrioid adenocarcinoma grade 1/2 ≥50% myoinvasion or 3 <50% myoinvasion. High myoinvasion, non-endometrioid histologies regardless cervical involvement any histology, All SLNs underwent pathologic ultra-staging. Nodal were presence macro- micro-metastases. comparison metastatic by assessment method performed using χ2 test multivariable logistic regression analysis. A total 996 included (333 intermediate-risk group 663 group). In 192/333 (58%) LND 141/333 (42%) SLN. detected 11% 9% SLN cohorts (p = .46). Increasing proportions staged observed after implementation (57% vs 78%) < .001). group, 412/663 (62%) LND, 251/663 (38%) 19% 14% cohorts, respectively .11). majority isolated tumor cells compared (71% 29%, p .01). (82% 88%) .02). analysis, no association either group. predominantly population, an algorithm did not compromise metastases. As more are comprehensively implementation, we expect accurate surgical staging adjuvant therapy allocation specific patient future.

Язык: Английский

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Upfront and interval debulking surgery in advanced/metastatic endometrial cancer in the era of molecular classification

European Journal of Obstetrics & Gynecology and Reproductive Biology, Год журнала: 2025, Номер 310, С. 113958 - 113958

Опубликована: Апрель 12, 2025

Язык: Английский

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Response to: Correspondence on ‘Predicting the risk of nodal disease with histological and molecular features in endometrial cancer: the prospective PROME trial’ by Aznar et al

International Journal of Gynecological Cancer, Год журнала: 2024, Номер 34(10), С. 1660 - 1660

Опубликована: Сен. 7, 2024

Язык: Английский

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Correspondence on ‘Predicting the risk of nodal disease with histological and molecular features in endometrial cancer: the prospective PROME trial’ by Bogani et al

International Journal of Gynecological Cancer, Год журнала: 2024, Номер 34(10), С. 1659 - 1659

Опубликована: Сен. 7, 2024

Язык: Английский

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“Risk factors for the involvement of sentinel lymph nodes in endometrial cancer (TRSGO-SLN-010)”

International Journal of Gynecological Cancer, Год журнала: 2024, Номер 35(1), С. 100041 - 100041

Опубликована: Дек. 31, 2024

This research was undertaken to identify risk factors for the involvement of sentinel lymph nodes (SLNs) in cases endometrial cancer. From February 2016 April 2021, 874 women with cancer treated SLN algorithm at 11 institutions were analyzed this retrospective study. Clinical and pathologic data reviewed, logistic regression applied predictive involvement. After exclusion 81 patients, remaining cohort 793 patients analyzed. The SLNs occurred 9.2% these (n = 73). In univariate analysis, seen be significantly higher among aged >60 years those high-grade tumors, non-endometrioid histology, lymphovascular space invasion, deep myometrial tumor diameters ≥2 cm, cervical stromal invasion. Multivariate analysis identified occurrence invasion (OR 2.42, 95% CI 1.29 4.56; p .006), 2.18, 1.13 4.21; .020), 7.27, 3.82 13.81; < .001) as independently treatment Deep found For which dissection not or could performed, independent are crucial guiding adjuvant therapy.

Язык: Английский

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Correspondence on ‘Predicting the Risk of nOdal disease with histological and Molecular features in Endometrial cancer the prospective PROME trial’

International Journal of Gynecological Cancer, Год журнала: 2024, Номер 35(1), С. 100038 - 100038

Опубликована: Дек. 31, 2024

Язык: Английский

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