Translational Cancer Research,
Год журнала:
2024,
Номер
13(7), С. 3599 - 3619
Опубликована: Июль 1, 2024
Neuroblastoma
(NB)
is
a
malignant
tumor
primarily
found
in
children,
presenting
significant
challenges
its
development
and
prognosis.
The
role
of
necroptosis
the
pathogenesis
NB
has
been
acknowledged
as
crucial
for
treatment.
This
study
aimed
to
investigate
key
genes
functional
pathways
associated
with
necroptosis,
well
immune
infiltration
analysis,
NB.
Furthermore,
we
evaluate
diagnostic
significance
these
prognostic
assessment
explore
their
potential
immunological
characteristics.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Март 6, 2025
Relapsed/refractory
neuroblastoma
is
a
type
of
malignant
solid
tumor
with
very
poor
prognosis
in
children.
Its
pathogenesis
complex,
involving
multiple
molecular
pathways
and
genetic
alterations.
Recent
studies
have
shown
that
MYCN
amplification,
ALK
mutation,
TERT
promoter
p53
pathway
inactivation,
chromosomal
instability
are
the
key
mechanisms
characteristics
relapsed/refractory
neuroblastoma.
Precision
treatment
strategies
targeting
these
certain
prospects
preclinical
clinical
practice.
This
review
focuses
on
relevant
neuroblastoma,
explores
its
relationship
response
prognosis,
briefly
introduces
current
to
provide
theoretical
basis
for
development
novel
personalized
therapeutic
regimens
improve
Sains Malaysiana,
Год журнала:
2024,
Номер
53(2), С. 359 - 367
Опубликована: Фев. 29, 2024
Polyalthia
bullata
King’s
root
yielded
a
new
compound
named
5-methylliridine
(1)
in
addition
to
six
previously
identified
compounds.
These
known
compounds
include
liriodenine
(2),
11-methoxyliriodenine
(3),
lysicamine
(4),
onychine
(5),
5-hydroxy-6-methoxyonychine
(6),
and
8-methoxyeupolauridine
(7).
The
structures
of
1-7
were
determined
through
spectroscopic
analysis.
Liriodenine
(2)
exhibited
remarkable
ability
decrease
the
cell
viability
cancerous
N2A
cells
22%
within
24
h
timeframe,
indicating
its
potential
as
an
anti-neuroblastoma
agent.
Molecular
docking
results
additionally
suggested
that
oxoaporphines
(1-4)
have
act
inhibitors
protein
kinases.
findings
highlight
therapeutic
P.
constituents
cancer
treatment,
particularly
neuroblastoma,
contribute
understanding
medicinal
properties.
ImmunoTargets and Therapy,
Год журнала:
2025,
Номер
Volume 14, С. 99 - 121
Опубликована: Фев. 1, 2025
As
important
innate
immune
cells,
natural
killer
(NK)
cells
play
an
essential
role
in
resisting
pathogen
invasion
and
eliminating
transformed
cells.
However,
the
hypoxic
microenvironment
caused
by
disease
conditions
is
physicochemical
factor
that
impairs
NK
cell
function.
With
increasing
prominence
of
immunotherapy,
there
has
been
a
surge
interest
developing
biological
means
through
which
may
overcome
inhibition
hypoxia
conditions.
Although
effects
shaping
functions
have
increasingly
recognized
investigated,
reviews
scantly.
A
comprehensive
understanding
how
adapt
to
can
provide
valuable
insights
into
functional
capacity
be
restored.
This
review
focuses
on
alterations
response
hypoxia.
It
delineates
mechanisms
at
transcriptional,
metabolic,
translational
levels.
Furthermore,
given
complexity
microenvironment,
we
also
elucidated
key
metabolites
Finally,
this
discusses
current
clinical
therapies
derived
from
targeting
The
study
adaptation
yielded
new
immunotherapy.
These
lead
development
novel
strategies
improve
treatment
infectious
diseases
cancer.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 15, 2025
Background
Neuroblastoma
(NB),
one
of
the
most
common
malignant
extracranial
solid
tumors
in
children,
is
highly
invasive
and
lethal
with
limited
treatment
efficacy.
This
study
aimed
to
establish
a
prognostic
model
advanced-stage
NB.
Methods
Differentially
expressed
genes
were
screened
validated
using
two
training
datasets
validation
dataset
from
Therapeutically
Applicable
Research
Generate
Effective
Treatments
Gene
Expression
Omnibus
databases.
Protein–protein
interaction
networks
developed
MCode
plug-in,
top
three
key
clusters
used
produce
candidate
genes.
We
performed
gene
set
enrichment
analysis
(GSEA),
ontology
(GO),
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
analysis,
immune
cell
infiltration,
drug
sensitivity
further
understand
functions
these
Kaplan–Meier
(K–M)
receiver
operating
characteristic
(ROC)
curves
check
their
prognosis
value.
Real-time
quantitative
polymerase
chain
reaction
(qPCR),
Western
blot
(WB),
immunohistochemistry
(IHC)
employed
verify
mRNA
protein
levels
clinical
samples.
Results
A
total
699
differentially
identified,
including
294
upregulated
405
downregulated
CNR1,
PRKACB,
CDKN3
,
PCLAF
found
significantly
affect
overall
survival
event-free
neuroblastoma
patients
positively
correlated
INSS
advanced
stages.
The
functional
four
revealed
cancer-promoting
effects
correlations
immune-inflammatory,
cycle,
p53
signaling
pathways.
After
stratifying
established
containing
above
genes,
different
patterns
observed
terms
infiltrating
proportion,
sensitivity,
expression
checkpoints.
Finally,
both
verification
assays
demonstrated
that
upregulated,
while
PRKACB
was
tissue
Conclusion
can
serve
as
new
biomarker
for
predicting
neuroblastoma.
Findings
on
infiltration
checkpoints
provide
novel
insights
immunotherapy
Cancers,
Год журнала:
2025,
Номер
17(11), С. 1812 - 1812
Опубликована: Май 29, 2025
Neuroblastoma
(NB)
is
the
most
prevalent
extracranial
childhood
tumor
and
third
leading
cause
of
death
from
cancer
in
children.
Despite
having
a
high
overall
survival
rate
for
low-
intermediate-risk
patients,
rates
high-risk
cases
remain
unsatisfactory.
The
current
standard
treatment
NB
involves
surgery,
chemotherapy,
radiotherapy,
autologous
stem
cell
transplantation,
immunotherapy
with
anti-ganglioside
GD2,
differentiation
therapy
isotretinoin.
Besides
not
being
enough
to
achieve
these
treatments
are
associated
significant
side
effects.
With
next-generation
sequencing
technologies,
better
understanding
genetic
epigenetic
landscapes
has
been
achieved.
This
led
study
novel
improve
reduce
toxicity
conventional
treatments.
Current
research
focusing
on
development
targeted
drugs
alterations,
protein
degraders.
Moreover,
enhance
anticancer
immune
responses
by
using
cell-engineering
techniques
chimeric
antigen
receptor
(CAR)
T
NK
cells
explored
target
cells.
Here,
we
review
promising
strategies
NB,
which
genetics,
epigenetics,
microenvironment,
landscape,
highlighting
preclinical
studies
ongoing
clinical
trials.
Biochemical Journal,
Год журнала:
2025,
Номер
482(11), С. 741 - 761
Опубликована: Май 28, 2025
Cancers
have
traditionally
been
classified
based
on
their
tissue
of
origin.
However,
with
advances
in
sophisticated
genome
sequencing
techniques
and
progression
toward
an
era
precision
medicine,
it
has
become
increasingly
clear
that
classifying
tumors
unifying
molecular
features
instead
origin
may
hold
the
key
to
improving
patient
outcomes.
Various
efforts
undertaken
address
this
critical
aspect
cancer
biology,
but
is
still
unclear
as
best
approach
stratify
into
different
classes.
One
define
many
small
subclasses
complex
signatures,
while
another
option
divide
cancers
larger
groups
higher-order
behavior.
This
latter
holds
appeal
provide
opportunities
identify
broadly
relevant
therapeutics.
our
understanding
these
fundamental
‘rules’
biology
how
they
can
be
used
better
classify
treat
its
infancy.
We
recently
demonstrated
functionally
stratified
binary
YAPon
YAPoff
super-classes
unique
therapeutic
vulnerabilities
distinct
expression
function
transcriptional
coactivators,
YAP
TAZ.
In
cancers,
TAZ
drive
oncogenesis,
whereas
are
tumor
suppressors.
review,
we
discuss
classes
a
focus
mechanisms
underlie
opposite
YAP/TAZ
well
potential
implications
findings.
