Translational Cancer Research,
Год журнала:
2024,
Номер
13(7), С. 3599 - 3619
Опубликована: Июль 1, 2024
Neuroblastoma
(NB)
is
a
malignant
tumor
primarily
found
in
children,
presenting
significant
challenges
its
development
and
prognosis.
The
role
of
necroptosis
the
pathogenesis
NB
has
been
acknowledged
as
crucial
for
treatment.
This
study
aimed
to
investigate
key
genes
functional
pathways
associated
with
necroptosis,
well
immune
infiltration
analysis,
NB.
Furthermore,
we
evaluate
diagnostic
significance
these
prognostic
assessment
explore
their
potential
immunological
characteristics.
Cancers,
Год журнала:
2024,
Номер
16(9), С. 1779 - 1779
Опубликована: Май 5, 2024
Neuroblastoma
(NB),
the
most
common
cancer
in
infants
and
solid
tumor
outside
brain
children,
grows
aggressively
responds
poorly
to
current
therapies.
We
have
identified
a
new
drug
(opaganib,
also
known
as
ABC294640)
that
modulates
sphingolipid
metabolism
by
inhibiting
synthesis
of
sphingosine
1-phosphate
(S1P)
kinase-2
elevating
dihydroceramides
inhibition
dihydroceramide
desaturase.
The
present
studies
sought
determine
potential
therapeutic
activity
opaganib
cell
culture
xenograft
models
NB.
Cytotoxicity
assays
demonstrated
NB
cells,
including
cells
with
amplified
MYCN,
are
effectively
killed
concentrations
well
below
those
accumulate
tumors
vivo.
Opaganib
was
shown
cause
dose-dependent
decreases
S1P
hexosylceramide
levels
Neuro-2a
while
concurrently
dihydroceramides.
As
other
reduced
c-Myc
Mcl-1
protein
expression
N-Myc
protein.
vivo
growth
xenografts
human
SK-N-(BE)2
MYCN
suppressed
oral
administration
at
doses
tolerated
mice.
Combining
temozolomide
plus
irinotecan,
considered
backbone
for
therapy
relapsed
or
refractory
NB,
resulted
increased
antitumor
compared
irinotecan
alone.
Mice
did
not
lose
additional
weight
when
combined
indicating
combination
is
tolerated.
has
additive
toward
checkpoint
inhibitor
anti-CTLA-4
antibody;
however,
anti-PD-1
anti-PD-L1
antibodies
provide
over
seen
Overall,
data
demonstrate
intracellular
signaling
inhibits
alone
anticancer
drugs.
Amplified
does
confer
resistance
opaganib,
and,
fact,
attenuates
both
N-Myc.
safety
been
established
clinical
trials
adults
advanced
severe
COVID-19,
so
excellent
treating
patients
particularly
antibody.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 19, 2024
Background
Neuroblastoma
(NB),
characterized
by
its
marked
heterogeneity,
is
the
most
common
extracranial
solid
tumor
in
children.
The
status
and
functionality
of
mitochondria
are
crucial
regulating
NB
cell
behavior.
While
significance
mitochondria-related
genes
(MRGs)
still
missing
key
knowledge.
Materials
methods
This
study
leverages
consensus
clustering
machine
learning
algorithms
to
construct
validate
an
MRGs-related
signature
NB.
Single-cell
data
analysis
experimental
validation
were
employed
characterize
pivotal
role
FEN1
within
cells.
Results
MRGs
facilitated
classification
patients
into
2
distinct
clusters
with
considerable
differences.
constructed
quantitative
indicators,
mtScore
mtRisk,
effectively
patient
clusters.
Notably,
outperformed
MYCN
predicting
prognosis
was
adept
at
representing
microenvironment
(TME),
stemness,
sensitivity
chemotherapeutic
agents
Cisplatin,
Topotecan,
Irinotecan.
FEN1,
identified
as
contributory
gene
signature,
found
play
a
communication
between
cells
TME,
developmental
trajectory
Experimental
validations
confirmed
FEN1’s
significant
influence
on
proliferation,
apoptosis,
cycle,
invasiveness.
Conclusion
developed
this
offers
novel
predictive
tool
for
assessing
prognosis,
immune
infiltration,
sensitivity.
Our
findings
unveil
critical
function
NB,
suggesting
potential
therapeutic
target.
Revista Foco,
Год журнала:
2024,
Номер
unknown, С. e5552 - e5552
Опубликована: Июль 22, 2024
Introdução:
neuroblastoma
é
uma
neoplasia
maligna
que
afeta
células
nervosas
simpáticas,
principalmente
na
medula
adrenal.
Esta
patologia
recorrente
infância,
apresenta
desafios
tanto
em
relação
à
detecção
precoce
quanto
ao
manejo
terapêutico.
O
presente
estudo
descreve
o
caso
de
um
paciente
foi
diagnosticado
com
congênito
no
1°
mês
vida,
tratamento
cirúrgico
e
evolução
favorável
até
momento.
Objetivo:
relatar
congênito,
seguido
revisão
narrativa
da
literatura,
ênfase
descrição
do
processo
diagnóstico,
opções
terapêuticas
seguimento
ambulatorial.
Método:
este
consiste
relato
literatura
narrativa.
A
coleta
dados
realizada
por
entrevistas
a
família,
aplicação
formulário
online
análise
dos
resultados
laboratoriais
imagens
utilizados
para
diagnóstico.
Os
artigos
científicos
selecionados
foram
publicados
período
2018
2024.
Relato
caso:
criança,
2
anos
idade
atualmente,
diagnósticada
tumoração
adrenal
direita,
confirmado
após
ressecção
cirúrgica
histopatológica.
Massa
cística
detectada
ultrassom
vias
urinárias
pós
natal,
realizado
virtude
dilatação
pelve
renal
esquerda
identificada
ultrassonografia
morfológica
2º
trimestre.
Frente
rápido
aumento
lesão,
40%
15
dias,
optou-se
pela
cirúrgica.
estadiamento
diagnóstico
indicou
acompanhamento
regular
10
idade.
Conclusão:
multidisciplinar
são
cruciais
bem-sucedido.
remoção
completa
lesão
levou
estabilidade
paciente,
desenvolvimento
adequado,
sem
intervenções
adicionais.
Translational Cancer Research,
Год журнала:
2024,
Номер
13(7), С. 3599 - 3619
Опубликована: Июль 1, 2024
Neuroblastoma
(NB)
is
a
malignant
tumor
primarily
found
in
children,
presenting
significant
challenges
its
development
and
prognosis.
The
role
of
necroptosis
the
pathogenesis
NB
has
been
acknowledged
as
crucial
for
treatment.
This
study
aimed
to
investigate
key
genes
functional
pathways
associated
with
necroptosis,
well
immune
infiltration
analysis,
NB.
Furthermore,
we
evaluate
diagnostic
significance
these
prognostic
assessment
explore
their
potential
immunological
characteristics.
