Exploration of the multiomics-based mechanisms of Gancao Nourishing-Yin decoction in regulating mitochondrial metabolic genes CYB5R3 and PICK1 to influence glioma progression DOI Creative Commons
Yufeng Chen, Anjing Zhang, Lei Li

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 8, 2025

Glioma is the most common malignancy of central nervous system, characterised by its high invasiveness and recurrence, which significantly limit therapeutic outcomes. Energy metabolism reprogramming, especially mitochondrial dysfunction, plays a pivotal role in tumour growth, survival, progression. Mitochondria serve as hub for energy production biosynthesis, adapting through alterations oxidative phosphorylation, lipid metabolism, tricarboxylic acid cycle to meet metabolic demands gliomas. Gancao Nourishing-Yin (GCNY) decoction, traditional herbal compound, has demonstrated potential antitumour effects, particularly modulating pathways stress, are critical cell adaptation. Genomic data from glioma GWAS dataset Finnish R11 database eQTL 13 distinct brain regions were analysed using Summary-data-based Mendelian Randomization(SMR) identify glioma-associated genes. MitoCarta3.0, genes, was used pinpoint mitochondrial-related Differentially expressed genes (DEGs) human microglial cells treated with GCNY extracted GEO GSE210945 cross-referenced SMR results key Colocalisation analysis, validation TCGA database, survival functional annotations performed explore mechanisms action. Integration MitoCarta3.0 identified 19 linked gliomas, primarily involved amino fatty metabolism. Among these, CYB5R3 PICK1 emerged strong genetic links signals (PPH4 = 1). CYB5R3, upregulated associated enhanced elevated reactive oxygen species (ROS) production, poor outcomes (HR 2.23, P < 0.001). PICK1, despite being downregulated, showed context-dependent roles progression, expression worse prognosis 2.86, moderate predictive capacity one-year (AUC 0.695). This study highlights identifying regulators influenced GCNY. By pathways, including ROS phosphorylation activity, offers novel multitarget strategy therapy. These findings underscore importance target gliomas provide new insights into integrated management.

Язык: Английский

Nanoparticle troopers: Infiltrating cancer cells for targeted therapies DOI
Shivam Rajput, Rishabha Malviya, Sankha Bhattacharya

и другие.

Nano-Structures & Nano-Objects, Год журнала: 2025, Номер 41, С. 101453 - 101453

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma DOI Creative Commons
Jacob S. Young, Nam Woo Cho, Calixto‐Hope G. Lucas

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

The glioblastoma tumor immune microenvironment (TIME) is an immunosuppressive barrier to therapy that encumbers responses checkpoint inhibition (ICI). Immunosuppressive cytokines, pro-tumor myeloid cells, and exhausted T-cells are hallmarks of the TIME. Here we integrate spatial single-cell analyses patient-matched human samples before after ICI with genetic, immunologic, single-cell, pharmacologic studies in preclinical models reveal interleukin-6 (IL-6) reprograms TIME sensitize mouse radiotherapy. Rare patients who achieve clinical have lower pre-treatment IL-6 levels compared glioblastomas do not respond ICI. Immune stimulatory gene suppresses murine glioblastoma. Furthermore, survival was longer Il-6 knockout mice orthotopic SB28 relative wild-type mice. blockade a neutralizing antibody transiently sensitizes anti-PD-1 by increasing MHCII+ monocytes, CD103+ migratory dendritic cells (DCs), CD11b+ conventional DCs, effector CD8+ T decreasing Tregs. To translate these findings combination treatment strategy for recurrent patients, show plus durably high-dose

Язык: Английский

Процитировано

0
Limitations of nomogram models in predicting survival outcomes for glioma patients DOI Creative Commons
Jihao Xue, Hang Liu, Lu Jiang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 18, 2025

Glioma represents a prevalent and malignant tumor of the central nervous system (CNS), it is essential to accurately predict survival glioma patients optimize their subsequent treatment plans. This review outlines most recent advancements viewpoints regarding application nomograms in prognosis research. With an emphasis on precision external applicability predictive models, we carried out comprehensive literature provided step-by-step guide for developing evaluating nomograms. A summary thirty-nine articles was produced. The majority nomogram-building research has used limited patient samples, disregarded proportional hazards (PH) assumption Cox regression some them have failed incorporate validation. Furthermore, capability influenced by selection incorporated risk factors. Overall, current accuracy moderately credible. development validation nomogram models ought adhere standardized set criteria, thereby augmenting worth clinical decision-making clinician-patient communication. Prior nomogram, imperative thoroughly scrutinize its statistical foundation, rigorously evaluate accuracy, and, whenever feasible, assess utilizing multicenter databases.

Язык: Английский

Процитировано

0
Exploration of the multiomics-based mechanisms of Gancao Nourishing-Yin decoction in regulating mitochondrial metabolic genes CYB5R3 and PICK1 to influence glioma progression DOI Creative Commons
Yufeng Chen, Anjing Zhang, Lei Li

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 8, 2025

Glioma is the most common malignancy of central nervous system, characterised by its high invasiveness and recurrence, which significantly limit therapeutic outcomes. Energy metabolism reprogramming, especially mitochondrial dysfunction, plays a pivotal role in tumour growth, survival, progression. Mitochondria serve as hub for energy production biosynthesis, adapting through alterations oxidative phosphorylation, lipid metabolism, tricarboxylic acid cycle to meet metabolic demands gliomas. Gancao Nourishing-Yin (GCNY) decoction, traditional herbal compound, has demonstrated potential antitumour effects, particularly modulating pathways stress, are critical cell adaptation. Genomic data from glioma GWAS dataset Finnish R11 database eQTL 13 distinct brain regions were analysed using Summary-data-based Mendelian Randomization(SMR) identify glioma-associated genes. MitoCarta3.0, genes, was used pinpoint mitochondrial-related Differentially expressed genes (DEGs) human microglial cells treated with GCNY extracted GEO GSE210945 cross-referenced SMR results key Colocalisation analysis, validation TCGA database, survival functional annotations performed explore mechanisms action. Integration MitoCarta3.0 identified 19 linked gliomas, primarily involved amino fatty metabolism. Among these, CYB5R3 PICK1 emerged strong genetic links signals (PPH4 = 1). CYB5R3, upregulated associated enhanced elevated reactive oxygen species (ROS) production, poor outcomes (HR 2.23, P < 0.001). PICK1, despite being downregulated, showed context-dependent roles progression, expression worse prognosis 2.86, moderate predictive capacity one-year (AUC 0.695). This study highlights identifying regulators influenced GCNY. By pathways, including ROS phosphorylation activity, offers novel multitarget strategy therapy. These findings underscore importance target gliomas provide new insights into integrated management.

Язык: Английский

Процитировано

0