Cancer Immunology Immunotherapy, Год журнала: 2024, Номер 74(1)
Опубликована: Дек. 30, 2024
Colorectal cancer (CRC) is the most common digestive in world. Microsatellite stability (MSS) and microsatellite instability (MSI-high) are important molecular subtypes of CRC closely related to tumor occurrence progression immunotherapy efficacy. The presence CD8
Язык: Английский
Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Фев. 4, 2025
Язык: Английский
Процитировано
0
World Journal of Surgical Oncology, Год журнала: 2025, Номер 23(1)
Опубликована: Апрель 9, 2025
The tertiary lymphoid structures (TLSs) are positively correlated with the prognosis of many solid tumors, including colorectal cancer. However, their prognostic significance in patients locally advanced rectal cancer (LARC) after neoadjuvant chemotherapy remains unclear. This study aimed to explore correlation between TLS parameters and LARC receiving chemotherapy. retrospective included treated at Harbin Medical University Cancer Hospital from 2012 2021. quantity, area, density TLSs tumor, normal, total tissues surgical specimens were determined. Overall survival (OS) was calculated surgery death any cause. assessed using Kaplan-Meier analysis Cox regression analysis. Multiplex immunofluorescence (mIF) staining used analyze maturity immune composition. 114 patients, whom 46.5% over 60 years old, 70.2% male. tumor region smaller than those normal regions (P < 0.001). A larger area higher (HR = 0.371, P 0.023 for area; HR 0.250, 0.005 density) significantly associated better OS. Moreover, a total-region low carcinoembryonic antigen (CEA) levels 0.028), positive responses therapy 0.001), Subgroup revealed that combining clinicopathologic features such as sex, age, cTNM stage, CEA levels, extramural vascular invasion further stratified prognosis. Additionally, mIF showed high 0.014); mature exhibited greater infiltration CD20⁺ B cells CD21⁺ follicular dendritic compared non-mature TLSs. parameters, particularly density, promising biomarkers undergoing not applicable.
Язык: Английский
Процитировано
0
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 16, 2025
Breast cancer represents the most prevalent form of tumors among females and is characterized by a significant genetic component. The brain frequent site metastasis for breast cancer. Although numerous loci associated with (BCBM) have been identified, critical regulatory genes underlying BCBM remain largely unclear. FinnGen R11 dataset was combined Genotype-Tissue Expression Project (GTEx) Transcriptome-wide Association Study (TWAS). Unified Test Molecular Signatures (UTMOST), Multimarker Analysis Genomic Annotation (MAGMA), Functional Summary-based Imputation (FUSION) were used to identify candidate genes. Summary-data-based mendelian randomization (SMR) co-localization performed further elucidate association between key BCBM. Finally, multiple external cohorts obtained validate findings. In our study, 12 new identified TWAS. Subsequently, both SMR shown that CAPS8 only expressed in tissues including frontal cortex cerebellar hemispheres Potential regulation CASP8 could occur findings ultimately validated clinical cohorts. Our study gene CASP8, which BCBM, providing insights into occurrence
Язык: Английский
Процитировано
0
Acta Neuropathologica Communications, Год журнала: 2025, Номер 13(1)
Опубликована: Май 3, 2025
Abstract Brain metastases (BrM) are the most common cancers in brain and linked to poor prognosis. Given high incidence often limited treatment options, understanding complexity of BrM tumor microenvironment is crucial for development novel therapeutic strategies. We performed transcriptome-wide gene expression profiling combined with spatial immune cell characterize 95 patients from different primary tumors. found that lung carcinoma malignant melanoma showed overall higher infiltration as compared breast carcinoma. RNA sequencing-based deconvolution revealed signatures indicative tertiary lymphoid structures (TLS) subsets BrM, mostly cancer melanoma. This finding was corroborated by multiplex immunofluorescence staining cells tissue sections. Detection TLS more treatment-naïve associated prolonged survival after diagnosis patients. Our findings highlight cellular diversity types suggest a role formation patient outcome.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Июнь 4, 2025
Esophageal cancer (EC), especially esophageal squamous cell carcinoma (ESCC), which is the most common subtype in China, one of aggressive gastrointestinal malignancies. Traditional treatments like surgery, radiotherapy, and chemotherapy have limited success, but study tertiary lymphoid structure (TLS) has opened new avenues for immunotherapy. TLS an ectopic immune cluster, including B cells, T dendritic cells (DCs), that forms chronic inflammation such as tumors. often found at tumor invasion margins linked to better prognosis EC patients, with higher density maturation associated prolonged survival. can also serve a biomarker assess immunotherapy outcomes. Further exploration molecular mechanisms could innovate treatments, by inducing formation improve therapy. This review summarizes characteristics EC, clinical findings, limitations directions current research, offering insights future strategies.
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2024, Номер 6(1)
Опубликована: Дек. 20, 2024
Abstract Metastatic brain tumors, also called metastasis (BM), represent a challenging complication of advanced tumors. Tumors that commonly metastasize to the include lung cancer and breast cancer. In recent years, prognosis for BM patients has improved, significant advancements have been made in both clinical preclinical research. This review focuses on originating from We briefly overview history epidemiology BM, as well current diagnostic treatment paradigms. Additionally, we summarize multiomics evidence mechanisms tumor occurrence development era artificial intelligence discuss role microenvironment. Preclinically, introduce establishment models, detailed molecular mechanisms, cutting‐edge methods. is primarily treated with comprehensive approach, including local treatments such surgery radiotherapy. For cancer, targeted therapy immunotherapy shown efficacy, while monoclonal antibodies, tyrosine kinase inhibitors, antibody–drug conjugates are effective BM. Multiomics approaches assist diagnosis treatment, revealing complex Moreover, agents often need cross blood–brain barrier achieve high intracranial concentrations, small‐molecule nanoparticles, peptide drugs. Addressing imperative.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Summary Brain metastases (BrM) are the most common cancers in brain. We performed transcriptome-wide gene expression profiling combined with spatial immune cell to characterize tumor microenvironment BrM from different primary tumors. found that lung carcinoma and malignant melanoma showed overall higher infiltration as compared breast carcinoma. RNA sequencing-based deconvolution revealed signatures indicative of tertiary lymphoid structures (TLS) subsets BrM, mostly cancer melanoma. This finding was corroborated by multiplex immunofluorescence staining cells tissue sections. Detection TLS more treatment-naïve associated prolonged survival after diagnosis patients. Our findings highlight cellular diversity types suggest a role formation for patient outcome.
Язык: Английский
Процитировано
0
Cancer Immunology Immunotherapy, Год журнала: 2024, Номер 74(1)
Опубликована: Дек. 30, 2024
Colorectal cancer (CRC) is the most common digestive in world. Microsatellite stability (MSS) and microsatellite instability (MSI-high) are important molecular subtypes of CRC closely related to tumor occurrence progression immunotherapy efficacy. The presence CD8
Язык: Английский
Процитировано
0