Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
276, С. 116280 - 116280
Опубликована: Апрель 3, 2024
In
recent
years,
accumulating
evidence
supports
that
occupational
exposure
to
solvents
is
associated
with
an
increased
incidence
of
Parkinson's
disease
(PD)
among
workers.
The
neurotoxic
effects
1-bromopropane
(1-BP),
a
widely
used
new-type
solvent,
are
well-established,
yet
data
on
its
relationship
the
etiology
PD
remain
limited.
Simultaneously,
high-fat
consumption
in
modern
society
recognized
as
significant
risk
factor
for
PD.
However,
whether
there
synergistic
effect
between
diet
and
1-BP
remains
unclear.
this
study,
adult
C57BL/6
mice
were
fed
either
chow
or
18
weeks
prior
12-week
treatment.
Subsequent
neurobehavioral
neuropathological
examinations
conducted
assess
parkinsonian
pathology.
results
demonstrated
produced
obvious
abnormalities
dopaminergic
degeneration
nigral
region
mice.
Importantly,
further
exacerbated
impact
motor
cognitive
Mechanistic
investigation
revealed
mitochondrial
damage
mtDNA
release
induced
by
activate
NLRP3
cGAS-STING
pathway-
mediated
neuroinflammatory
response,
ultimately
lead
necroptosis
neurons.
summary,
our
study
unveils
potential
link
chronic
PD-like
pathology
no-motor
defects
experimental
animals,
long-term
can
promote
neurotoxicity,
which
underscores
pivotal
role
environmental
factors
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
1879(4), С. 189107 - 189107
Опубликована: Май 9, 2024
The
functions
of
mitochondria,
including
energy
production
and
biomolecule
synthesis,
have
been
known
for
a
long
time.
Given
the
rising
incidence
cancer,
role
mitochondria
in
cancer
has
become
increasingly
popular.
Activated
by
components
released
various
pathways
interact
with
each
other
to
induce
immune
responses
protect
organisms
from
attack.
However,
play
dual
roles
progression
cancer.
Abnormalities
proteins,
which
are
elementary
structures
closely
linked
oncogenesis.
Both
aberrant
accumulation
intermediates
mutations
enzymes
result
generation
Therefore,
targeting
treat
may
be
new
strategy.
Several
drugs
aimed
at
inhibiting
mutated
accumulated
tested
clinically.
Here,
we
discuss
current
understanding
interactions
between
mitochondrial
functions,
responses,
Furthermore,
as
hopeful
targets
therapy,
providing
insights
into
future
therapeutic
strategies.
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(9), С. 3806 - 3815
Опубликована: Авг. 1, 2023
Inflammation
and
social
behavior
deficits
are
associated
with
a
number
of
neuropsychiatric
disorders.
Chronic
stress,
major
risk
factor
for
depression
other
mental
health
conditions
is
known
to
increase
inflammatory
responses
impairments.
Disturbances
in
mitochondria
function
have
been
found
chronic
stress
conditions,
however
the
mechanisms
that
link
mitochondrial
dysfunction
stress-induced
not
well
understood.
In
this
study,
we
restraint
(RS)
induces
significant
increases
serum
cell-free
DNA
(cf-mtDNA)
levels
mice,
systemic
Deoxyribonuclease
I
(DNase
I)
treatment
attenuated
RS-induced
behavioral
deficits.
Our
findings
revealed
potential
roles
mitophagy
Mitochondrial
antiviral-signaling
protein
(MAVS)
mediating
changes
cf-mtDNA
behavior.
Furthermore,
showed
inhibition
Toll-like
receptor
9
(TLR9)
attenuates
mtDNA-induced
Together,
these
show
cf-mtDNA-TLR9
signaling
critical
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 26, 2024
Photosensitivity
is
observed
in
numerous
autoimmune
diseases
and
drives
poor
quality
of
life
disease
flares.
Elevated
epidermal
type
I
interferon
(IFN)
production
primes
for
photosensitivity
enhanced
inflammation,
but
the
substrates
that
sustain
amplify
this
cycle
remain
undefined.
Here,
we
show
IFN-induced
Z-DNA
binding
protein
1
(ZBP1)
stabilizes
ultraviolet
(UV)B-induced
cytosolic
derived
from
oxidized
mitochondrial
DNA.
ZBP1
significantly
upregulated
epidermis
adult
pediatric
patients
with
photosensitivity.
Strikingly,
lupus
keratinocytes
accumulate
extensive
after
UVB,
transfection
results
stronger
IFN
through
cGAS-STING
activation
compared
to
B-DNA.
knockdown
abrogates
UV-induced
responses,
whereas
overexpression
a
lupus-like
phenotype
spontaneous
accumulation
production.
Our
highlight
as
critical
mediators
UVB-induced
inflammation
uncover
how
IFNs
prime
cutaneous
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
276, С. 116280 - 116280
Опубликована: Апрель 3, 2024
In
recent
years,
accumulating
evidence
supports
that
occupational
exposure
to
solvents
is
associated
with
an
increased
incidence
of
Parkinson's
disease
(PD)
among
workers.
The
neurotoxic
effects
1-bromopropane
(1-BP),
a
widely
used
new-type
solvent,
are
well-established,
yet
data
on
its
relationship
the
etiology
PD
remain
limited.
Simultaneously,
high-fat
consumption
in
modern
society
recognized
as
significant
risk
factor
for
PD.
However,
whether
there
synergistic
effect
between
diet
and
1-BP
remains
unclear.
this
study,
adult
C57BL/6
mice
were
fed
either
chow
or
18
weeks
prior
12-week
treatment.
Subsequent
neurobehavioral
neuropathological
examinations
conducted
assess
parkinsonian
pathology.
results
demonstrated
produced
obvious
abnormalities
dopaminergic
degeneration
nigral
region
mice.
Importantly,
further
exacerbated
impact
motor
cognitive
Mechanistic
investigation
revealed
mitochondrial
damage
mtDNA
release
induced
by
activate
NLRP3
cGAS-STING
pathway-
mediated
neuroinflammatory
response,
ultimately
lead
necroptosis
neurons.
summary,
our
study
unveils
potential
link
chronic
PD-like
pathology
no-motor
defects
experimental
animals,
long-term
can
promote
neurotoxicity,
which
underscores
pivotal
role
environmental
factors
