Frontiers in Plant Science,
Год журнала:
2022,
Номер
13
Опубликована: Июль 26, 2022
TGA
transcription
factors
are
essential
regulators
of
various
cellular
processes,
their
activity
connected
to
different
hormonal
pathways,
interacting
proteins
and
regulatory
elements.
Belonging
the
basic
region
leucine
zipper
(bZIP)
family,
TGAs
operate
by
binding
target
DNA
sequence
as
dimers
through
a
conserved
bZIP
domain.
Despite
sharing
core
DNA-binding
sequence,
paralogues
exert
somewhat
preferences.
Sequence
variability
N-
C-terminal
protein
parts
indicates
importance
in
defining
functional
specificity
interactions
with
diverse
proteins,
affecting
properties.
In
this
review,
we
provide
short
concise
summary
on
plant
from
structural
point
view,
including
relation
characteristics
roles
regulation.
Developmental Biology,
Год журнала:
2022,
Номер
484, С. 75 - 87
Опубликована: Фев. 17, 2022
Ever
since
their
first
report
in
1984,
Antennapedia-type
homeobox
(Hox)
genes
have
been
involved
such
a
series
of
interesting
observations,
particular
due
to
conserved
clustered
organization
between
vertebrates
and
arthropods,
that
one
may
legitimately
wonder
about
the
origin
this
heuristic
value.
In
essay,
I
consider
different
examples
where
Hox
gene
clusters
instrumental
providing
conceptual
advances,
taken
from
various
fields
research
mostly
involving
vertebrate
embryos.
These
touch
upon
our
understanding
genomic
evolution,
revisiting
19th
century
views
on
relationships
development
evolution
building
new
framework
understand
long-range
pleiotropic
regulation
during
development.
then
discuss
whether
high
value
family,
when
considered
as
an
epistemic
object,
is
related
its
structure
(and
absence
thereof
some
animal
species)
and,
if
so,
what
it
genetic
oddities
made
them
so
generous
scientific
community
with
information.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Дек. 15, 2022
Histone
modifications
are
deposited
by
chromatin
modifying
enzymes
and
read
out
proteins
that
recognize
the
modified
state.
BRD4-NUT
is
an
oncogenic
fusion
protein
of
acetyl
lysine
reader
BRD4
binds
to
acetylase
p300
enables
formation
long-range
intra-
interchromosomal
interactions.
We
here
examine
how
acetylation
reading
writing
enable
such
show
NUT
contains
acidic
transcriptional
activation
domain
TAZ2
p300.
use
NMR
investigate
structure
complex
found
has
autoinhibitory
role
for
NUT-TAZ2
interaction
or
mutations
in
cancer
interfere
with
autoinhibition
allosterically
activate
results
a
self-organizing,
acetylation-dependent
feed-forward
reaction
interactions
bromodomain
multivalent
acetyl-lysine
binding.
discuss
implications
organisation,
gene
regulation
dysregulation
disease.
Frontiers in Plant Science,
Год журнала:
2022,
Номер
13
Опубликована: Июль 26, 2022
TGA
transcription
factors
are
essential
regulators
of
various
cellular
processes,
their
activity
connected
to
different
hormonal
pathways,
interacting
proteins
and
regulatory
elements.
Belonging
the
basic
region
leucine
zipper
(bZIP)
family,
TGAs
operate
by
binding
target
DNA
sequence
as
dimers
through
a
conserved
bZIP
domain.
Despite
sharing
core
DNA-binding
sequence,
paralogues
exert
somewhat
preferences.
Sequence
variability
N-
C-terminal
protein
parts
indicates
importance
in
defining
functional
specificity
interactions
with
diverse
proteins,
affecting
properties.
In
this
review,
we
provide
short
concise
summary
on
plant
from
structural
point
view,
including
relation
characteristics
roles
regulation.
