Exploring the Nutritional Profiling and Therapeutic Effect of Fermented Garlic on Alcohol-Induced Liver Injury in Animal Model DOI Creative Commons
Mavra Javed, Waqas Ahmed, Azmat Ullah

и другие.

Fermentation, Год журнала: 2025, Номер 11(5), С. 240 - 240

Опубликована: Апрель 24, 2025

Black garlic, a fermented product of fresh has shown promising potential as culinary ingredient and medicinal remedy. This study examined the microbiological makeup, nutritional profile, health advantages black garlic to better understand its health-endorsing properties. Thermus, Corynebacterium, Streptococcus, Brevundimonas were among prominent taxa found when microbial diversity in samples was investigated using Illumina MiSeq sequencing. provided insight into complex interactions between microorganisms during fermentation process clarified distinctive qualities garlic. expanded scope include garlic’s therapeutic potential, specifically relation liver function hangovers caused by alcohol, addition complexity. Significant damage revealed alcohol-treated rats serum biochemical indicators histological stains; this lessened administration particularly at higher dosages. Furthermore, showed hepatoprotective effects attributed high phenolic flavonoid contents. These results offer novel understanding they lay out possibilities for creation functional drugs treat alcohol-induced damage. Conclusively, diverse composition also advances our knowledge makeup advantages. In summary, research highlights flexible medical tool, having implications both gastronomic uses.

Язык: Английский

Alcohol-associated liver disease DOI Creative Commons
Bryan Mackowiak, Yaojie Fu, Luca Maccioni

и другие.

Journal of Clinical Investigation, Год журнала: 2024, Номер 134(3)

Опубликована: Фев. 1, 2024

Alcohol-associated liver disease (ALD) is a major cause of chronic worldwide, and comprises spectrum several different disorders, including simple steatosis, steatohepatitis, cirrhosis, superimposed hepatocellular carcinoma. Although tremendous progress has been made in the field ALD over last 20 years, pathogenesis remains obscure, there are currently no FDA-approved drugs for treatment ALD. In this Review, we discuss new insights into therapeutic targets ALD, utilizing study multiomics other cutting-edge approaches. The potential translation these studies clinical practice therapy deliberated. We also preclinical models interplay metabolic dysfunction, alcohol-associated cancer, heterogeneity some translational research prospects

Язык: Английский

Процитировано

127
The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease DOI
Luis Antonio Díaz, Juan Pablo Arab, Alexandre Louvet

и другие.

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 20(12), С. 764 - 783

Опубликована: Авг. 15, 2023

Язык: Английский

Процитировано

103
Liver diseases: epidemiology, causes, trends and predictions DOI Creative Commons

Can Gan,

Yuan Yuan, Haiyuan Shen

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Фев. 4, 2025

Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.

Язык: Английский

Процитировано

6
Alcohol and the mechanisms of liver disease DOI Creative Commons
Mo Chen, Wanglei Zhong, Weiqi Xu

и другие.

Journal of Gastroenterology and Hepatology, Год журнала: 2023, Номер 38(8), С. 1233 - 1240

Опубликована: Июль 9, 2023

Abstract Alcoholic liver disease (ALD), which is a leading cause of morbidity and mortality worldwide, covers large spectrum injuries ranging from simple steatosis to steatohepatitis, advanced fibrosis, cirrhosis, hepatocellular carcinoma. The pathogenesis ALD includes genetic epigenetic alterations, oxidative stress, acetaldehyde‐mediated toxicity cytokine chemokine‐induced inflammation, metabolic reprogramming, immune damage, dysbiosis the gut microbiota. This review discusses progress in molecular mechanism ALD, could provide evidence for further research on potential therapeutic strategies targeting these pathways.

Язык: Английский

Процитировано

24
Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease DOI
Fernanda Raya Tonetti, Álvaro Eguileor, Marko Mrdjen

и другие.

Hepatology, Год журнала: 2024, Номер 80(6), С. 1342 - 1371

Опубликована: Май 1, 2024

The growing recognition of the role gut microbiome’s impact on alcohol-associated diseases, especially in liver disease, emphasizes need to understand molecular mechanisms involved governing organ-organ communication identify novel avenues combat diseases. gut-liver axis refers bidirectional and interaction between liver. Intestinal microbiota plays a pivotal maintaining homeostasis within axis, this significant disease. intricate intestine involves multiple cellular components each organ that enable them carry out their physiological functions. In review, we focus approaches understanding how chronic alcohol exposure impacts microbiome individual cells intestine, as well ethanol machinery required for intraorgan interorgan communication.

Язык: Английский

Процитировано

16
Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease DOI

Aritoshi Koizumi,

Kosuke Kaji, Norihisa Nishimura

и другие.

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(28), С. 3428 - 3446

Опубликована: Июль 24, 2024

BACKGROUND Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality, but there are no therapeutic targets modalities to prevent ALD-related fibrosis. Peroxisome proliferator activated receptor (PPAR) α δ play key role in lipid metabolism intestinal barrier homeostasis, which major contributors the pathological progression ALD. Meanwhile, elafibranor (EFN), dual PPARα PPARδ agonist, has reached phase III clinical trial for treatment metabolic dysfunction-associated steatotic primary biliary cholangitis. However, benefits EFN ALD unknown. AIM To evaluate inhibitory effects on fibrosis gut-intestinal dysfunction an mouse model. METHODS was induced female C57BL/6J mice by feeding 2.5% ethanol (EtOH)-containing Lieber-DeCarli liquid diet intraperitoneally injecting carbon tetrachloride thrice weekly (1 mL/kg) 8 weeks. (3 10 mg/kg/day) orally administered during experimental period. Histological molecular analyses were performed assess effect steatohepatitis, fibrosis, integrity. The HepG2 lipotoxicity Caco-2 function evaluated cell-based assays. RESULTS hepatic steatosis, apoptosis, model significantly attenuated treatment. promoted lipolysis β-oxidation enhanced autophagic antioxidant capacities EtOH-stimulated cells, primarily through activation. Moreover, inhibited Kupffer cell-mediated inflammatory response, with blunted exposure lipopolysaccharide (LPS) toll like 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling. improved hyperpermeability restoring tight junction proteins autophagy inhibiting apoptosis proinflammatory responses. protective cells predominantly mediated CONCLUSION reduced accumulation enhancing hepatocyte capacities, suppressing LPS/TLR4/NF-κB-mediated responses function.

Язык: Английский

Процитировано

14
Inflammation in Alcohol-Associated Hepatitis: Pathogenesis and Therapeutic Targets DOI Creative Commons
Dechun Feng, Seonghwan Hwang, Adrien Guillot

и другие.

Cellular and Molecular Gastroenterology and Hepatology, Год журнала: 2024, Номер 18(3), С. 101352 - 101352

Опубликована: Янв. 1, 2024

Alcohol-associated hepatitis (AH) is an acute-on-chronic liver injury that occurs in patients with chronic alcohol-associated disease (ALD). Patients severe AH have high short-term mortality and lack effective pharmacologic therapies. Inflammation believed to be one of the key factors promoting progression has been actively investigated as therapeutic targets over last several decades, but no inflammatory identified so far. In this review, we discuss how cells mediators produced by these contribute development AH, focus on neutrophils macrophages. The crosstalk between nonparenchymal pathogenesis elaborated. We also deliberate application recent cutting-edge technologies characterizing inflammation AH. Finally, potential for are briefly summarized.

Язык: Английский

Процитировано

13
Solanum nigrum L. berries extract ameliorated the alcoholic liver injury by regulating gut microbiota, lipid metabolism, inflammation, and oxidative stress DOI

Xueying Wang,

Ziqi Sun,

Xiaoli Wang

и другие.

Food Research International, Год журнала: 2024, Номер 188, С. 114489 - 114489

Опубликована: Май 9, 2024

Язык: Английский

Процитировано

13
Oxidative stress in alcoholic liver disease, focusing on proteins, nucleic acids, and lipids: A review DOI

Weiwen Lai,

Jiahua Zhang,

Jiawei Sun

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134809 - 134809

Опубликована: Авг. 16, 2024

Язык: Английский

Процитировано

13
Regulatory mechanisms of the probiotic-targeted gut–liver axis for the alleviation of alcohol-related liver disease: a review DOI

Feiyu Yang,

Xiangfei Li, Jing Sun

и другие.

Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 22

Опубликована: Фев. 5, 2025

Alcohol abuse-triggered alcohol-related liver disease (ALD) has become as a global public health concern that substantially affects the well-being and clinical status of patients. Although modern medicine provides various treatments for ALD, their effectiveness is limited can lead to adverse side effects. Probiotics have been employed prevent, alleviate, even treat with promising results. However, few comprehensive reviews are available on how they mitigate ALD by targeting gut-liver axis. This review systematically clarifies specific mediators axis in healthy states. It also describes alterations observed ALD. Furthermore, this thoroughly summarizes underlying mechanisms through which probiotics act relieve discusses current challenges faced research applications. Finally, we discuss future prospects using improves our understanding supports development application target therapeutic use.

Язык: Английский

Процитировано

2