Cell Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
The Science of The Total Environment, Год журнала: 2025, Номер 969, С. 178921 - 178921
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
0
Biomolecules, Год журнала: 2025, Номер 15(3), С. 361 - 361
Опубликована: Март 2, 2025
Thyroid hormones (THs) are important modulators of many metabolic processes, being strictly associated with the control energy balance, mainly through activities on brain, white and brown adipose tissue, skeletal muscle, liver, pancreas. In this review, principal mechanisms TH regulation processes will be discussed THs’ relevance in disease progression evaluated, especially cardiovascular context correlated diseases. Moreover, we discuss regulatory role events a special focus process “browning”, which consists gradual acquisition by adipocytes physical functional characteristics adipocytes. The advancements research molecular proposed physiopathological discussed.
Язык: Английский
Процитировано
0
Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)
Опубликована: Март 27, 2025
Abstract Background Chronic stress in daily life is a well-known trigger for various health issues. Despite advancements obesity research, the mechanisms governing lipid metabolism adipose tissue during cachexia remain poorly understood. Methods A chronic restraint (CRS) model was used to induce significant physiological and psychological mice. Mice were subjected 6 h of 50 mL plastic tubes seven consecutive days. fasting control group included comparison. Post-stress assessments behavioural tests, glucose insulin tolerance tests indirect calorimetry. Blood samples collected mRNA protein analyses. Results CRS induced changes mice, including depression-like behaviours, weight loss reduced sensitivity. Notably, caused extensive remodelling. White (WAT) underwent ‘browning’ accompanied by an increase expression thermogenic proteins. This counteracted stress-induced ‘whitening’ brown (BAT), which exhibited impaired thermogenesis functionality, thereby maintaining energy balance systematically. The glucocorticoid receptor (GR) plays crucial role regulation these changes. GR levels inversely correlated BAT WAT, but aligned with patterns proteins across tissues. These findings suggest that under metabolic stress, mediates tissue-specific responses tissues, driving functional phenotypic transitions WAT maintain homeostasis. Conclusions study provides novel insights into contrasting phenotypes emaciation highlights critical GRs remodelling its potential as therapeutic target. Addressing GR-mediated tissues may help alleviate dysfunction promote browning, enhancing resistance.
Язык: Английский
Процитировано
0
European Journal of Clinical Investigation, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Despite growing evidence, the mechanisms connecting adipose tissue (AT) function to type 2 diabetes (T2DM) remain incompletely understood. A detailed analysis of AT transcriptomes could offer valuable insights into this relationship. Here, we examined gene expression patterns in bulk subcutaneous AT, focusing on biological pathways and cellular composition associated with glycated haemoglobin (HbA1c) levels. transcriptomic dataset was obtained from samples 901 adults collected during elective surgical procedures. We characterized within association blood HbA1c levels by performing cell deconvolution analysis. also conducted differential overrepresentation analyses. validated our cross-sectional study using two independent validation cohorts, further downstream Subcutaneous subjects increased had lower adipocytes, smooth muscle, pericytes other endothelial numbers. Pathways included senescence telomere-related extracellular matrix organisation. identified RHO GTPases not previously linked glucose homeostasis, a possible sexual dimorphism shaped obesity state. The findings were confirmed both longitudinal cohorts. At level, HLA-DR, CCL13, S100A4 mRNA strongly correlated This underscores utility transcriptome unravelling T2DM complexities. Our enhance knowledge homeostasis' molecular underpinnings, paving way for potential therapeutic targets mitigate impact dysfunction metabolic diseases.
Язык: Английский
Процитировано
0
Cell Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0