Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 13, 2024

Язык: Английский

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Targeting ferroptosis: opportunities and challenges of mesenchymal stem cell therapy for type 1 diabetes mellitus

Stem Cell Research & Therapy, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 4, 2025

Abstract Type 1 diabetes mellitus (T1DM) is characterized by progressive β-cell death, leading to loss and insufficient insulin secretion. Mesenchymal stem cells (MSCs) transplantation currently one of the most promising methods for replacement therapy. However, recent studies have shown that ferroptosis not only key mechanisms but also reasons extensive cell death within a short period time after MSCs transplantation. Ferroptosis new type regulated (RCD) iron-dependent accumulation lipid peroxides. Due weak antioxidant capacity β-cells, they are susceptible cytotoxic stimuli such as oxidative stress (OS), therefore ferroptosis. Transplanted extremely perturbations in their microenvironment, especially OS, which can weaken induce through In pathophysiological process T1DM, large amount reactive oxygen species (ROS) produced, causing OS. Therefore, targeting may be way protect β-cells improve therapeutic effect This review reviews research related MSCs, summarizes developed strategies help inhibit study aims understand mechanism transplantation, emphasize importance protecting improving survival function transplanted provide direction therapy T1DM future.

Язык: Английский

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Paris saponin VII promotes ferroptosis to inhibit breast cancer via Nrf2/GPX4 axis

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 697, С. 149524 - 149524

Опубликована: Янв. 15, 2024

Язык: Английский

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Heterogeneous redox responses in NHDF cells primed to enhance mitochondrial bioenergetics

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2024, Номер 1871(1), С. 167495 - 167495

Опубликована: Сен. 4, 2024

Язык: Английский

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Vinpocetine protects against osteoarthritis by inhibiting ferroptosis and extracellular matrix degradation via activation of the Nrf2/GPX4 pathway

Phytomedicine, Год журнала: 2024, Номер 135, С. 156115 - 156115

Опубликована: Сен. 30, 2024

Язык: Английский

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The Potential Regulatory Role of Ferroptosis in Orthodontically Induced Inflammatory Root Resorption

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13617 - 13617

Опубликована: Дек. 19, 2024

People, in increasing numbers, are seeking orthodontic treatment to correct malocclusion, while some of them suffering from orthodontically induced inflammatory root resorption (OIIRR). Recent evidence suggests that the immune-inflammatory response occurring during bone remodeling may be responsible for OIIRR. Ferroptosis, a new type programmed cell death (PCD), has been found have close interrelation with inflammation disease progression. While ferroptosis extensively studied bone-related diseases, its role OIIRR is poorly understood. Considering tooth shares lot similar characteristics bone, it reasonable hypothesize contributes development Nevertheless, direct supporting this theory currently lacking. In review, we introduced and elucidated mechanisms underlying movement (OTM) OIIRR, special focus on pivotal plays these processes. Additionally, covered recent research exploring connections between ferroptosis. Lastly, emphasized important regulatory function homeostasis. Further investigations required clarify modulation develop novel potential therapeutic strategies management

Язык: Английский

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Multi-Dimensional Analysis of the Regulatory Network of Ferroptosis in Osteoarthritis: Progress, Challenges, and Future Directions

Опубликована: Янв. 1, 2024

Язык: Английский

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