A Scoping Review of the Implications and Applications of Body Composition Assessment in Locally Advanced and Locally Recurrent Rectal Cancer

Cancers, Год журнала: 2025, Номер 17(5), С. 846 - 846

Опубликована: Фев. 28, 2025

Background: A strong body of evidence exists demonstrating deleterious relationships between abnormal composition (BC) and outcomes in non-complex colorectal cancer. Complex rectal cancer (RC) includes locally advanced recurrent tumours. This scoping review aims to summarise the current examining BC complex RC. Methods: literature search was performed on Ovid MEDLINE, EMBASE, Cochrane databases. Original studies adult patients with RC were included. Two authors undertook screening full-text reviews. Results: Thirty-five Muscle quantity most commonly studied metric, sarcopenia appearing predict mortality, recurrence, neoadjuvant therapy outcomes, postoperative complications. In particular, 10 examined response, six showing a significant association sarcopenia. Only one study interventions for improving RC, only specifically undergoing pelvic exenteration. Marked variation also observed terms how quantified, both anatomical location cut-off values defined. Conclusions: Sarcopenia appears mortality recurrence An opportunity meta-analysis poorer outcomes. There is paucity poor BC. Further research exenteration surgery lacking. Pitfalls identified include variances measured computed tomography whether external muscle adipose tissue are appropriate particular population.

Язык: Английский

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Kinsenoside Suppresses DGAT1-Mediated Lipid Droplet Formation to Trigger Ferroptosis in Triple-Negative Breast Cancer

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2322 - 2322

Опубликована: Март 5, 2025

Triple-negative breast cancer (TNBC) presents limited therapeutic options and is characterized by a poor prognosis. Although Kinsenoside (KIN) possesses wide range of pharmacological activities, its effect mechanism in TNBC remain unclear. The objective this research was to explore the effectiveness molecular mechanisms KIN on TNBC. Xenograft experiment carried out assess impact vivo. vitro evaluated through analysis cell cytotoxicity colony formation assays. Oil Red O staining BODIPY 493/503 fluorescence were employed detect lipid droplet (LD) formation. Transcriptomics inhibitor-rescue experiments conducted investigate role Mechanistic experiments, including quantitative real-time polymerase chain reaction (RT-qPCR), Western blotting, diacylglycerol acyltransferase 1 (DGAT1) overexpression assay, flow cytometric uncover regulatory inhibited tumor growth without causing obvious toxicity liver kidneys. In demonstrated that significantly viability proliferation cells, accompanied decreased LD content. Polyunsaturated fatty acids (PUFAs) levels increased KIN. Furthermore, transcriptomics revealed induced ferroptosis cells. could regulate ferroptosis-related proteins. Lipid peroxidation, iron accumulation, GSH depletion also confirmed this. inducer mitigated KIN-induced DGAT1 attenuated effects proliferation. trigger Our findings suppressing DGAT1-mediated formation, thereby demonstrating promising

Язык: Английский

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The prognostic value of myosteatosis in pancreatic cancer: A systematic review and meta-analysis

Clinical Nutrition, Год журнала: 2024, Номер 43(12), С. 116 - 123

Опубликована: Окт. 16, 2024

Язык: Английский

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Advancements and future directions in American Journal of Physiology-Cell Physiology: a 2024 editorial update

AJP Cell Physiology, Год журнала: 2024, Номер 327(6), С. C1681 - C1685

Опубликована: Дек. 1, 2024

Язык: Английский

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