Kynurenine Pathway after Kidney Transplantation: Friend or Foe?
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9940 - 9940
Опубликована: Сен. 14, 2024
Kidney
transplantation
significantly
improves
the
survival
of
patients
with
end-stage
kidney
disease
(ESKD)
compared
to
other
forms
replacement
therapy.
However,
transplant
recipients’
outcomes
are
not
fully
satisfactory
due
increased
risk
cardiovascular
diseases,
infections,
and
malignancies.
Immune-related
complications
remain
biggest
challenge
in
management
graft
recipients.
Despite
broad
spectrum
immunosuppressive
agents
available
more
detailed
methods
used
monitor
their
effectiveness,
chronic
allograft
nephropathy
remains
most
common
cause
rejection.
The
kynurenine
(KYN)
pathway
is
main
route
tryptophan
(Trp)
degradation,
resulting
production
a
plethora
substances
ambiguous
properties.
Conversion
Trp
KYN
by
enzyme
indoleamine
2,3-dioxygenase
(IDO)
rate-limiting
step
determining
formation
next
from
pathway.
IDO
activity,
as
well
subsequent
metabolites
pathway,
highly
dependent
on
balance
between
pro-
anti-inflammatory
conditions.
Moreover,
products
themselves
possess
immunomodulating
properties,
e.g.,
modify
activity
control
immune-related
processes.
were
widely
studied
neurological
disorders
but
recently
gained
attention
researchers
context
immune-mediated
diseases.
Evidence
that
this
degradation
may
represent
peripheral
tolerogenic
significant
implications
for
further
fueled
interest.
Our
review
aimed
present
recent
knowledge
about
role
pathogenesis,
diagnosis,
monitoring,
treatment
complications.
Язык: Английский
Depression, stress, and tryptophan metabolism through the kynurenine pathway: treatment strategies from the perspective of Chinese herbal medicine
Metabolic Brain Disease,
Год журнала:
2024,
Номер
40(1)
Опубликована: Ноя. 15, 2024
Язык: Английский
Unraveling the nexus of NAD+ metabolism and diabetic kidney disease: insights from murine models and human data
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Май 21, 2024
Background
Nicotinamide
adenine
dinucleotide
(NAD+)
is
a
critical
coenzyme
involved
in
kidney
disease,
yet
its
regulation
diabetic
disease
(DKD)
remains
inadequately
understood.
Objective
Therefore,
we
investigated
the
changes
of
NAD+
levels
DKD
and
underlying
mechanism.
Methods
Alternations
biosynthesis
enzymes
were
detected
kidneys
from
streptozotocin-induced
mouse
model
by
real-time
PCR
immunoblot.
The
distribution
de
novo
synthetic
was
explored
via
immunohistochemical
study.
metabolite
measured
LC-MS.
Human
data
NephroSeq
analyzed
to
verify
our
findings.
Results
study
showed
that
decreased
kidneys.
Both
mRNA
protein
kynurenine
3-monooxygenase
(KMO)
synthesis
pathway
decreased,
while
salvage
consuming
remained
unchanged.
Further
analysis
human
suggested
KMO,
primarily
expressed
proximal
tubules
shown
staining,
consistently
downregulated
Conclusion
Our
demonstrated
KMO
might
be
responsible
for
reduction
kidneys,
offering
valuable
insights
into
complex
regulatory
mechanisms
DKD.
Язык: Английский
Urine metabolite changes after cardiac surgery predict acute kidney injury
Qi Zeng,
Jinghan Feng,
Xinni Zhang
и другие.
Clinical Kidney Journal,
Год журнала:
2024,
Номер
17(8)
Опубликована: Июль 16, 2024
Acute
kidney
injury
(AKI)
is
a
serious
complication
in
patients
undergoing
cardiac
surgery,
with
the
underlying
mechanism
remaining
elusive
and
lack
of
specific
biomarkers
for
surgery-associated
AKI
(CS-AKI).
We
performed
an
untargeted
metabolomics
analysis
urine
samples
procured
from
cohort
or
without
at
6
24
h
following
surgery.
Based
on
differential
urinary
metabolites
discovered,
we
further
examined
expressions
key
metabolic
enzymes
that
regulate
these
during
using
mouse
model
ischemia-reperfusion
(IRI)
hypoxia-treated
tubular
epithelial
cells
(TECs).
The
metabolomic
profiles
were
significantly
different
those
non-AKI
patients,
including
upregulation
tryptophan
metabolism-
aerobic
glycolysis-related
metabolites,
such
as
l-tryptophan
d-glucose-1-phosphate,
downregulation
fatty
acid
oxidation
(FAO)
tricarboxylic
(TCA)
cycle-related
metabolites.
Spearman
correlation
showed
serum
creatinine
was
positively
correlated
indole,
which
had
high
accuracy
predicting
AKI.
In
animal
experiments,
demonstrated
expression
rate-limiting
glycolysis,
hexokinase
II
(HK2),
upregulated
renal
IRI.
However,
TCA
enzyme
citrate
synthase
downregulated
after
vitro,
hypoxia
induced
TECs.
addition,
FAO-related
gene
peroxisome
proliferator-activated
receptor
alpha
(PPARα)
remarkably
This
study
presents
related
to
CS-AKI,
indicating
rewiring
metabolism
AKI,
identifying
potential
biomarkers.
Язык: Английский