Anesthetics in pathological cerebrovascular conditions DOI

Yuhui Hou,

Wei Ye,

Ziyuan Tang

и другие.

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

The increasing prevalence of pathological cerebrovascular conditions, including stroke, hypertensive encephalopathy, and chronic disorders, underscores the importance anesthetic considerations for affected patients. Preserving cerebral oxygenation blood flow during anesthesia is paramount to prevent neurological deterioration. Furthermore, protecting vulnerable neurons from damage crucial optimal outcomes. Recent research suggests that agents may provide a potentially therapeutic approach managing conditions. Anesthetics target neural mechanisms underlying dysfunction, thereby modulating neuroinflammation, against ischemic injury, improving hemodynamics. However, strategies regarding mechanisms, dosage, indications remain uncertain. This review aims clarify physiological effects, action, reported neuroprotective benefits anesthetics in patients with various Investigating effects disease holds promise developing novel strategies.

Язык: Английский

Molecular Mechanisms of Propofol‐Induced Cognitive Impairment: Suppression of Critical Hippocampal Pathways DOI
Xiangdong Zhou,

Shasha Dong,

Yuhai Xu

и другие.

Journal of Neurochemistry, Год журнала: 2025, Номер 169(4)

Опубликована: Апрель 1, 2025

ABSTRACT Propofol, a commonly used anesthetic, is known to cause postoperative cognitive dysfunction (POCD), particularly after prolonged or high‐dose administration. Its effects on neural remodeling in the hippocampal region, which vital for function, remain poorly understood. This study employs single‐cell RNA sequencing (scRNA‐seq) and high‐throughput transcriptomic analysis elucidate molecular mechanisms by propofol impairs remodeling. Our findings indicate that suppresses (5‐Hydroxytryptamine Receptor 1A/Glutamate 2/Phosphoinositide 3‐Kinase Regulatory Subunit 1) HTR1A/GRIA2/PIK3R1 signaling pathway, contributing mice. In vitro experiments reveal treatment reduces expression of HTR1A/GRIA2/PIK3R1‐related factors, decreases neuronal activity synaptic plasticity, increases apoptosis inflammation. vivo demonstrate significant impairments spatial memory learning abilities mice treated with propofol. These results provide new insights into long‐term anesthetic drugs offer scientific basis their judicious use clinical practice. The highlights potential strategies targets preventing treating POCD, emphasizing importance understanding underlying anesthetic‐induced dysfunction. image

Язык: Английский

Процитировано

0
Research progress of propofol in alleviating cerebral ischemia/reperfusion injury DOI

Haijing Zheng,

Xian Zhong Xiao,

Yiming Han

и другие.

Pharmacological Reports, Год журнала: 2024, Номер 76(5), С. 962 - 980

Опубликована: Июль 2, 2024

Язык: Английский

Процитировано

3
Inhibition of the NLRP3/caspase-1 cascade related pyroptosis relieved propofol-induced neuroinflammation and cognitive impairment in developing rats. DOI

Zhiheng Zhang,

Hui Chen, Lin Han

и другие.

Free Radical Biology and Medicine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

0
Anesthetics in pathological cerebrovascular conditions DOI

Yuhui Hou,

Wei Ye,

Ziyuan Tang

и другие.

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Окт. 25, 2024

The increasing prevalence of pathological cerebrovascular conditions, including stroke, hypertensive encephalopathy, and chronic disorders, underscores the importance anesthetic considerations for affected patients. Preserving cerebral oxygenation blood flow during anesthesia is paramount to prevent neurological deterioration. Furthermore, protecting vulnerable neurons from damage crucial optimal outcomes. Recent research suggests that agents may provide a potentially therapeutic approach managing conditions. Anesthetics target neural mechanisms underlying dysfunction, thereby modulating neuroinflammation, against ischemic injury, improving hemodynamics. However, strategies regarding mechanisms, dosage, indications remain uncertain. This review aims clarify physiological effects, action, reported neuroprotective benefits anesthetics in patients with various Investigating effects disease holds promise developing novel strategies.

Язык: Английский

Процитировано

0