Preservation of Vascular Endothelial Function in Late-Onset Postmenopausal Women
Circulation Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
BACKGROUND:
Postmenopausal
women
(PMW)
who
complete
menopause
at
a
late
age
(55+
years)
have
lower
cardiovascular
disease
risk
than
PMW
normal
(45–54
years).
However,
the
influence
of
late-onset
on
vascular
endothelial
dysfunction
is
unknown.
Moreover,
mechanisms
by
which
later
may
modulate
function
remain
to
be
determined.
METHODS:
We
measured
(brachial
artery
flow-mediated
dilation
[FMD
BA
])
in
age-matched
late-
and
normal-onset
young
premenopausal
reference
group.
determined
mitochondrial
reactive
oxygen
species
(mitoROS)–related
suppression
(change
FMD
with
an
acute
dose
mitochondria-targeted
antioxidant
MitoQ;
ΔFMD
BA,
MTQ
)
PMW.
The
effects
serum
from
mitoROS
bioactivity
human
aortic
cells
culture
were
assessed.
Metabolomics
analyses
combination
metabolite
level
normalization
cell
exposure
experiments
performed
identify
circulating
factors
contributing
bioactivity.
RESULTS:
was
women.
>50%
higher
versus
positively
related
menopause.
Serum
but
not
induced
compared
negatively
Seventeen
metabolites
significantly
differed
between
PMW;
15
lipid
specific;
8
triglyceride
derived.
TG(16:0)
most
strongly
correlated
Normalization
concentrations
match
levels
abrogated
differences
serum-treated
cells.
CONCLUSIONS:
Late-onset
associated
preservation
function,
mediated
mitoROS-associated
oxidative
stress.
A
more
favorable
profile
metabolites,
specifically
triglyceride-derived
contributes
These
findings
provide
new
insight
into
possible
reduced
Язык: Английский
Apparently Healthy Young Black Adults Report Lower Total Fluid Intake and Exhibit Higher Plasma Copeptin than Young White Adults
Nutrition Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Association Between Mediterranean Diet and Other Healthy Habits and Sociodemographic Variables with the Values of Vascular and Heart Age in Spanish Workers
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 903 - 903
Опубликована: Март 5, 2025
Introduction:
The
assessment
of
cardiovascular
risk
has
traditionally
relied
on
validated
scales
designed
to
estimate
the
likelihood
experiencing
a
event
within
specific
timeframe.
In
recent
years,
novel
methodologies
have
emerged,
offering
more
objective
evaluation
this
through
indicators
such
as
vascular
age
(VA)
and
heart
(HA).
Objective:
This
study
aimed
investigate
relationship
between
sociodemographic
factors,
lifestyle
behaviors,
their
impact
VA
HA.
Materials
Methods:
A
dual
design,
encompassing
both
cross-sectional
longitudinal
retrospective
approaches,
was
conducted
among
cohort
employees.
variables
assessed
included
characteristics
(age,
sex,
socioeconomic
status)
health-related
habits
(smoking,
physical
activity,
adherence
Mediterranean
diet,
alcohol
consumption).
Results:
findings
revealed
that
all
analyzed
were
significantly
associated
with
elevated
HA
values.
Among
these,
demonstrated
strongest
association,
odds
ratios
(OR)
114.91
(95%
CI:
100.45-131.43)
for
high
34.48
31.41-37.56)
VA.
Conclusions:
profile
individuals
most
at
encompasses
males
advanced
age,
characterized
by
low
status,
sedentary
lifestyle,
poor
regular
consumption.
Язык: Английский
Multidimensional health status and its impact on health care consumption behavior among elderly people with chronic diseases: evidence from CHARLS in China
Frontiers in Psychology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 16, 2025
Purpose
This
study
aims
to
provide
a
comprehensive
understanding
of
the
multidimensional
health
status
elderly
individuals
with
chronic
diseases
in
China
and
examine
its
impact
on
their
healthcare
consumption
behavior.
Methods
A
chi-square
test
was
conducted
assess
variations
behavior
across
different
categories.
Additionally,
logistic
regression
model
employed
identify
key
determinants
influencing
among
from
perspective.
Results
The
results
indicated
statistically
significant
association
between
(
p
<
0.05).
Furthermore,
analysis
identified
dyslipidemia,
regular
participation
social
activities,
children’s
financial
support
(≥¥5,801
yuan
per
year)
as
contributors
conditions
Conclusion
findings
this
suggest
that
both
physical
play
positive
role
enhancing
These
highlight
importance
targeted
policy
interventions
integrate
management
engagement
strategies
improve
accessibility
utilization
population.
Язык: Английский
Differences in ischemic heart disease between males and females using predictive artificial intelligence models
Electronic Journal of General Medicine,
Год журнала:
2024,
Номер
21(5), С. em607 - em607
Опубликована: Сен. 19, 2024
<b>Background:
</b>Cardiovascular
health
and
preventative
strategies
are
influenced
by
the
sex
of
individuals.
To
forecast
cardiac
events
or
detect
ischemic
heart
disease
(IHD)
early,
machine-learning
algorithms
can
analyze
complex
patient
data
patterns.
Early
detection
allows
for
lifestyle
changes,
medication
management,
invasive
treatments
to
slow
progression
improve
outcomes.<br
/>
<b>Aim</b>:
compare
predict
differences
in
primary
sources
IHD
burden
between
males
females
various
age
groups,
geographical
regions,
death
versus
alive,
comorbidity
levels.<br
<b>Methods:
</b>A
predictive
retrospective
design
was
implemented
this
study.
Electronic
records
were
extracted,
which
equally
distributed
among
with
IHD.
The
dataset
consisted
patients
who
admitted
2015
2022.
Two
eight
models
generated
Modeler
software
study:
Bayesian
network
model,
achieved
highest
area
under
curve
score
(0.600),
Chi-squared
automatic
interaction
(CHAID)
overall
accuracy
(57.199%).<br
<b>Results:
</b>The
study
sample
included
17,878
men
women,
58%
whom
had
no
comorbidities
1.7%
died.
Age,
Charlson
index
score,
location
all
predicted
IHD,
but
more
influential.
analysis
showed
that
odds
40-59
60-79,
mortality
risk
80-100.
North
south
Jordan
higher
rates
middle-aged
from
north
middle
governorates
according
CHAID.<br
<b>Conclusion:
</b>By
using
artificial
intelligence,
clinicians
outcomes,
treatment
quality,
save
lives
fight
against
cardiovascular
illnesses.
patterns
outcomes.
Язык: Английский