Pathogenesis of Dementia
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 543 - 543
Опубликована: Дек. 29, 2022
According
to
Alzheimer’s
Disease
International,
55
million
people
worldwide
are
living
with
dementia.
Dementia
is
a
disorder
that
manifests
as
set
of
related
symptoms,
which
usually
result
from
the
brain
being
damaged
by
injury
or
disease.
The
symptoms
involve
progressive
impairments
in
memory,
thinking,
and
behavior,
accompanied
emotional
problems,
difficulties
language,
decreased
motivation.
most
common
variant
dementia
disease
dominated
cognitive
disorders,
particularly
memory
loss,
impaired
personality,
judgmental
disorders.
So
far,
all
attempts
treat
dementias
removing
their
rather
than
causes
have
failed.
Therefore,
presented
narrative
review,
I
will
attempt
explain
etiology
perspective
energy
metabolism
dysfunction
an
aging
brain.
hope
this
perspective,
though
perhaps
too
simplified,
bring
us
closer
essence
aging-related
neurodegenerative
disorders
soon
allow
develop
new
preventive/therapeutic
strategies
our
struggle
dementia,
disease,
Parkinson’s
Язык: Английский
Adaptive control of functional connectivity: dorsal and ventral limbic divisions regulate the dorsal and ventral neocortical networks
Cerebral Cortex,
Год журнала:
2023,
Номер
33(12), С. 7870 - 7895
Опубликована: Март 23, 2023
Abstract
The
connectional
anatomy
of
the
primate
cortex
is
now
well-defined
by
Structural
Model,
in
which
adjacent
cortical
areas
are
interconnected
an
organized
network
hierarchy
communication
and
control.
computational
theory
“active
inference”
can
be
aligned
with
this
architecture,
proposing
that
predictions
descend
from
higher
association
to
updated
ascending
prediction
errors
lower
(i.e.
primary)
sensory
motor
areas.
Given
connectivity,
limbic
networks
at
apex
cerebral
must
then
responsible
for
most
general
expectancies,
propagated
through
organize
multiple
component
levels
experience
behavior.
Anatomical
evidence
suggests
there
dual
divisions,
reflecting
archicortical
(dorsal)
paleocortical
(ventral)
derivations,
resulting
fundamentally
different
neural
mechanisms
managing
expectancies
across
corticolimbic
hierarchy.
In
functional
connectivity
literature,
dorsal
attention
seen
provide
top-down
or
endogenous
control
attention,
whereas
ventral
provides
stimulus
bound
exogenous
attentional
We
review
indicating
dorsal,
division
system
a
feedforward,
impulsive,
mode
motive
control,
ventral,
feedback
constraint
linked
events.
Язык: Английский
The Loss of Spatiality and Temporality in Twilight Consciousness: The Emergence of Exogenous Psychosis Induced by Novel Psychoactive Substances
Psychopathology,
Год журнала:
2024,
Номер
57(3), С. 248 - 258
Опубликована: Янв. 1, 2024
<b><i>Background:</i></b>
The
state
of
twilight
consciousness
is
marked
by
a
focused
narrowing
awareness,
maintaining
vigilance
and
attention
while
simultaneously
experiencing
perceptual
shifts
in
the
surrounding
environment.
It
crucial
to
recognize
that
this
represents
not
just
contraction
but
also
an
expansion
conscious
experience.
<b><i>Summary:</i></b>
Substances
abuse,
particularly
new
psychoactive
substances,
play
significant
role
inducing
state.
They
achieve
deconstructing
essential
components
consciousness,
such
as
perception
time
space.
<b><i>Key
Message:</i></b>
This
paper
aimed
explore
phenomenon
shed
light
on
how
substances
can
alter
space
during
phase,
potentially
triggering
exogenous
psychosis.
comprehensive
inquiry
employs
phenomenological
approach
study
recognizing
it
primary
tool
for
ascribing
significance
intricate
yet
often
overlooked
aspect
psychopathology.
Язык: Английский
Adaptive consolidation of active inference: excitatory and inhibitory mechanisms for organizing feedforward and feedback memory systems in sleep
Cerebral Cortex,
Год журнала:
2025,
Номер
35(5)
Опубликована: Май 1, 2025
Abstract
Cognitive
self-organization
rests
on
activity-dependent
plasticity
to
extend
the
ontogenetic
process
of
neural
differentiation
and
integration
cerebral
cortex
in
each
act
cognition.
This
account
neurocognitive
growth
can
be
formulated
terms
active
inference
learning.
The
organism
regulates
synaptic
connectivity
as
it
seeks
its
goals
actively,
through
excitatory,
feedforward
expectancies
that
manifest
species-specific
affordances.
These
adaptive
are
modified
reactively,
inhibitory
feedback
error-correction
fit
predict
environmental
encounters.
Although
behavior,
concomitant
plasticity,
occur
during
waking,
architecture
requires
ongoing
consolidation
refinement
sleep.
We
propose
memory
sleep
is
a
continuation
neurodevelopmental
proceeds
kind
inversion
waking
inference:
NREM
first
refines
brain’s
representations
new,
unpredicted
experiences
implementing
mechanisms
long-term
depression
both
differentiate
stabilize
new
for
consolidation.
REM
then
updates
organism’s
generative
world
model
light
this
learning
excitatory
potentiation
plasticity.
thereby
reconsolidates
integrates
adaptive,
predictions,
Bayesian
priors
effective
coping.
Язык: Английский
Continuity and change in neural plasticity through embryonic morphogenesis, fetal activity‐dependent synaptogenesis, and infant memory consolidation
Developmental Psychobiology,
Год журнала:
2023,
Номер
65(8)
Опубликована: Ноя. 7, 2023
There
is
an
apparent
continuity
in
human
neural
development
that
can
be
traced
to
venerable
themes
of
vertebrate
morphogenesis
have
shaped
the
evolution
reptilian
telencephalon
(including
both
primitive
three-layered
cortex
and
basal
ganglia)
then
subsequent
mammalian
six-layered
neocortex.
In
this
theoretical
analysis,
we
propose
evolutionary-developmental
analysis
these
general
morphogenetic
help
explain
embryonic
dual
divisions
limbic
system
control
dorsal
ventral
networks
These
include
archicortical
(dorsal
limbic)
Papez
circuits
regulated
by
hippocampus
organize
spatial,
contextual
memory,
as
well
paleocortical
(ventral
object
memory.
We
review
evidence
are
controlled
differential
actions
brainstem
lemnothalamic
midbrain
collothalamic
arousal
systems,
respectively,
thereby
traversing
subcortical
neuraxis.
systems
first
seen
shaping
phyletic
foundations
forebrain
embryogenesis.
They
provide
modes
activity-dependent
synaptic
organization
active
(lemnothalamic)
quiet
(collothalamic)
stages
fetal
sleep.
Finally,
regulatory
mature
form
major
memory
consolidation
postnatal
development,
including
rapid
eye
movement
implicit
social
attachment
year,
then-in
a
stage-the
non-REM
explicit
integral
autonomy
individuation
second
year
life.
Язык: Английский
Feasibility of a Personal Neuromorphic Emulation
Опубликована: Июль 15, 2024
The
representation
of
intelligence
is
achieved
by
patterns
connections
among
neurons
in
brains
and
machines.
Brains
grow
continuously,
such
that
their
develop
through
activity-dependent
specification
with
the
continuing
ontogenesis
individual
experience.
theory
active
inference
proposes
developmental
organization
sentient
systems
reflects
general
processes
informatic
self-evidencing,
minimization
free
energy,
may
be
described
information
terms
are
not
dependent
on
a
specific
physical
substrate.
At
certain
level
complexity,
self-evidencing
living
(self-organizing)
becomes
hierarchic
reentrant,
effective
consciousness
emerges
as
consequence
good
regulator.
These
principles
imply
an
adequate
reconstruction
computational
dynamics
human
brain
possible
sufficient
neuromorphic
emulation.
Язык: Английский
Cortical development in the structural model and free energy minimization
Cerebral Cortex,
Год журнала:
2024,
Номер
34(10)
Опубликована: Окт. 1, 2024
Abstract
A
model
of
neocortical
development
invoking
Friston’s
Free
Energy
Principle
is
applied
within
the
Structural
Model
Barbas
et
al.
and
associated
functional
interpretation
advanced
by
Tucker
Luu.
Evolution
a
neural
field
with
Hebbian
anti-Hebbian
plasticity,
maximizing
synchrony
minimizing
axonal
length
apoptotic
selection,
leads
to
paired
connection
systems
mirror
symmetry,
interacting
via
Markov
blankets
along
their
line
reflection.
Applied
radial
lines
in
Model,
primary
blanket
emerges
between
centrifugal
synaptic
flux
layers
2,3
5,6,
versus
centripetal
flow
layer
4,
orientations
4
give
rise
differing
shape
movement
sensitivities
characteristic
neurons
dorsal
ventral
neocortex.
Prediction
error
minimization
integrates
limbic
subcortical
networks
Synaptic
bypassing
triggers
arousal
response
surprising
stimuli,
enabling
subsequent
adaptation.
As
progresses
ubiquitous
separated
enclosed
blankets-within-blankets
arise
throughout
neocortex,
creating
typical
order
characteristics
columnar
noncolumnar
cortex.
Язык: Английский
Efeitos da sonata k448 de Mozart na recordação da memória do medo em camundongos
Pâmela Mayara de Oliveira,
Ana Laura Macahiba Lorena,
J.A. Ferreira
и другие.
Brazilian Journal of Health Review,
Год журнала:
2024,
Номер
7(3), С. e70043 - e70043
Опубликована: Май 29, 2024
Este
trabalho
investigou
o
impacto
da
Sonata
K448
de
Mozart
na
recordação
memória
medo
previamente
extinta
em
camundongos,
utilizando
procedimentos
comportamentais
e
análises
estatísticas,
buscando
compreender
os
mecanismos
envolvidos
formação
extinção
aversiva,
com
potenciais
implicações
terapêuticas
distúrbios
relacionados
como
transtorno
do
estresse
pós-traumático.
Os
camundongos
foram
expostos
à
música
durante
a
gestação,
amamentação
fase
adulta,
seguida
por
testes
condicionamento
som/choque,
recordação.
dados
registrados
analisados,
incluindo
medidas
congelamento
indicador
para
extinção.
A
análise
estatística
avaliou
relação
temporal
efeitos
exposição
medo.
resultados
mostraram
que
não
houve
diferença
significativa
entre
grupos
fêmeas
ou
machos
no
teste
recordação,
indica
teve
efeito
mensurável
dos
animais
ambos
sexos,
sem
disbiose.
Feasibility of a Personal Neuromorphic Emulation
Entropy,
Год журнала:
2024,
Номер
26(9), С. 759 - 759
Опубликована: Сен. 5, 2024
The
representation
of
intelligence
is
achieved
by
patterns
connections
among
neurons
in
brains
and
machines.
Brains
grow
continuously,
such
that
their
develop
through
activity-dependent
specification,
with
the
continuing
ontogenesis
individual
experience.
theory
active
inference
proposes
developmental
organization
sentient
systems
reflects
general
processes
informatic
self-evidencing,
minimization
free
energy.
We
interpret
this
to
imply
mind
may
be
described
information
terms
are
not
dependent
on
a
specific
physical
substrate.
At
certain
level
complexity,
self-evidencing
living
(self-organizing)
becomes
hierarchical
reentrant,
effective
consciousness
emerges
as
consequence
good
regulator.
propose
these
principles
an
adequate
reconstruction
computational
dynamics
human
brain/mind
possible
sufficient
neuromorphic
emulation.
Язык: Английский