Feasibility of a Personal Neuromorphic Emulation DOI Creative Commons
Don M. Tucker,

Phan Luu

Entropy, Год журнала: 2024, Номер 26(9), С. 759 - 759

Опубликована: Сен. 5, 2024

The representation of intelligence is achieved by patterns connections among neurons in brains and machines. Brains grow continuously, such that their develop through activity-dependent specification, with the continuing ontogenesis individual experience. theory active inference proposes developmental organization sentient systems reflects general processes informatic self-evidencing, minimization free energy. We interpret this to imply mind may be described information terms are not dependent on a specific physical substrate. At certain level complexity, self-evidencing living (self-organizing) becomes hierarchical reentrant, effective consciousness emerges as consequence good regulator. propose these principles an adequate reconstruction computational dynamics human brain/mind possible sufficient neuromorphic emulation.

Язык: Английский

Pathogenesis of Dementia DOI Open Access
Janusz Błaszczyk

International Journal of Molecular Sciences, Год журнала: 2022, Номер 24(1), С. 543 - 543

Опубликована: Дек. 29, 2022

According to Alzheimer’s Disease International, 55 million people worldwide are living with dementia. Dementia is a disorder that manifests as set of related symptoms, which usually result from the brain being damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, accompanied emotional problems, difficulties language, decreased motivation. most common variant dementia disease dominated cognitive disorders, particularly memory loss, impaired personality, judgmental disorders. So far, all attempts treat dementias removing their rather than causes have failed. Therefore, presented narrative review, I will attempt explain etiology perspective energy metabolism dysfunction an aging brain. hope this perspective, though perhaps too simplified, bring us closer essence aging-related neurodegenerative disorders soon allow develop new preventive/therapeutic strategies our struggle dementia, disease, Parkinson’s

Язык: Английский

Процитировано

44

Adaptive control of functional connectivity: dorsal and ventral limbic divisions regulate the dorsal and ventral neocortical networks DOI
Don M. Tucker,

Phan Luu

Cerebral Cortex, Год журнала: 2023, Номер 33(12), С. 7870 - 7895

Опубликована: Март 23, 2023

Abstract The connectional anatomy of the primate cortex is now well-defined by Structural Model, in which adjacent cortical areas are interconnected an organized network hierarchy communication and control. computational theory “active inference” can be aligned with this architecture, proposing that predictions descend from higher association to updated ascending prediction errors lower (i.e. primary) sensory motor areas. Given connectivity, limbic networks at apex cerebral must then responsible for most general expectancies, propagated through organize multiple component levels experience behavior. Anatomical evidence suggests there dual divisions, reflecting archicortical (dorsal) paleocortical (ventral) derivations, resulting fundamentally different neural mechanisms managing expectancies across corticolimbic hierarchy. In functional connectivity literature, dorsal attention seen provide top-down or endogenous control attention, whereas ventral provides stimulus bound exogenous attentional We review indicating dorsal, division system a feedforward, impulsive, mode motive control, ventral, feedback constraint linked events.

Язык: Английский

Процитировано

15

The Loss of Spatiality and Temporality in Twilight Consciousness: The Emergence of Exogenous Psychosis Induced by Novel Psychoactive Substances DOI
Valerio Ricci, Giuseppe Maina,

Giovanni Martinotti

и другие.

Psychopathology, Год журнала: 2024, Номер 57(3), С. 248 - 258

Опубликована: Янв. 1, 2024

<b><i>Background:</i></b> The state of twilight consciousness is marked by a focused narrowing awareness, maintaining vigilance and attention while simultaneously experiencing perceptual shifts in the surrounding environment. It crucial to recognize that this represents not just contraction but also an expansion conscious experience. <b><i>Summary:</i></b> Substances abuse, particularly new psychoactive substances, play significant role inducing state. They achieve deconstructing essential components consciousness, such as perception time space. <b><i>Key Message:</i></b> This paper aimed explore phenomenon shed light on how substances can alter space during phase, potentially triggering exogenous psychosis. comprehensive inquiry employs phenomenological approach study recognizing it primary tool for ascribing significance intricate yet often overlooked aspect psychopathology.

Язык: Английский

Процитировано

5

Adaptive consolidation of active inference: excitatory and inhibitory mechanisms for organizing feedforward and feedback memory systems in sleep DOI
Don M. Tucker,

Phan Luu,

Karl Friston

и другие.

Cerebral Cortex, Год журнала: 2025, Номер 35(5)

Опубликована: Май 1, 2025

Abstract Cognitive self-organization rests on activity-dependent plasticity to extend the ontogenetic process of neural differentiation and integration cerebral cortex in each act cognition. This account neurocognitive growth can be formulated terms active inference learning. The organism regulates synaptic connectivity as it seeks its goals actively, through excitatory, feedforward expectancies that manifest species-specific affordances. These adaptive are modified reactively, inhibitory feedback error-correction fit predict environmental encounters. Although behavior, concomitant plasticity, occur during waking, architecture requires ongoing consolidation refinement sleep. We propose memory sleep is a continuation neurodevelopmental proceeds kind inversion waking inference: NREM first refines brain’s representations new, unpredicted experiences implementing mechanisms long-term depression both differentiate stabilize new for consolidation. REM then updates organism’s generative world model light this learning excitatory potentiation plasticity. thereby reconsolidates integrates adaptive, predictions, Bayesian priors effective coping.

Язык: Английский

Процитировано

0

Continuity and change in neural plasticity through embryonic morphogenesis, fetal activity‐dependent synaptogenesis, and infant memory consolidation DOI

Phan Luu,

Don M. Tucker

Developmental Psychobiology, Год журнала: 2023, Номер 65(8)

Опубликована: Ноя. 7, 2023

There is an apparent continuity in human neural development that can be traced to venerable themes of vertebrate morphogenesis have shaped the evolution reptilian telencephalon (including both primitive three-layered cortex and basal ganglia) then subsequent mammalian six-layered neocortex. In this theoretical analysis, we propose evolutionary-developmental analysis these general morphogenetic help explain embryonic dual divisions limbic system control dorsal ventral networks These include archicortical (dorsal limbic) Papez circuits regulated by hippocampus organize spatial, contextual memory, as well paleocortical (ventral object memory. We review evidence are controlled differential actions brainstem lemnothalamic midbrain collothalamic arousal systems, respectively, thereby traversing subcortical neuraxis. systems first seen shaping phyletic foundations forebrain embryogenesis. They provide modes activity-dependent synaptic organization active (lemnothalamic) quiet (collothalamic) stages fetal sleep. Finally, regulatory mature form major memory consolidation postnatal development, including rapid eye movement implicit social attachment year, then-in a stage-the non-REM explicit integral autonomy individuation second year life.

Язык: Английский

Процитировано

7

Feasibility of a Personal Neuromorphic Emulation DOI Open Access
Don M. Tucker,

Phan Luu

Опубликована: Июль 15, 2024

The representation of intelligence is achieved by patterns connections among neurons in brains and machines. Brains grow continuously, such that their develop through activity-dependent specification with the continuing ontogenesis individual experience. theory active inference proposes developmental organization sentient systems reflects general processes informatic self-evidencing, minimization free energy, may be described information terms are not dependent on a specific physical substrate. At certain level complexity, self-evidencing living (self-organizing) becomes hierarchic reentrant, effective consciousness emerges as consequence good regulator. These principles imply an adequate reconstruction computational dynamics human brain possible sufficient neuromorphic emulation.

Язык: Английский

Процитировано

1

Cortical development in the structural model and free energy minimization DOI Creative Commons
James L. Wright, Paul Bourke

Cerebral Cortex, Год журнала: 2024, Номер 34(10)

Опубликована: Окт. 1, 2024

Abstract A model of neocortical development invoking Friston’s Free Energy Principle is applied within the Structural Model Barbas et al. and associated functional interpretation advanced by Tucker Luu. Evolution a neural field with Hebbian anti-Hebbian plasticity, maximizing synchrony minimizing axonal length apoptotic selection, leads to paired connection systems mirror symmetry, interacting via Markov blankets along their line reflection. Applied radial lines in Model, primary blanket emerges between centrifugal synaptic flux layers 2,3 5,6, versus centripetal flow layer 4, orientations 4 give rise differing shape movement sensitivities characteristic neurons dorsal ventral neocortex. Prediction error minimization integrates limbic subcortical networks Synaptic bypassing triggers arousal response surprising stimuli, enabling subsequent adaptation. As progresses ubiquitous separated enclosed blankets-within-blankets arise throughout neocortex, creating typical order characteristics columnar noncolumnar cortex.

Язык: Английский

Процитировано

1

Efeitos da sonata k448 de Mozart na recordação da memória do medo em camundongos DOI Open Access

Pâmela Mayara de Oliveira,

Ana Laura Macahiba Lorena,

J.A. Ferreira

и другие.

Brazilian Journal of Health Review, Год журнала: 2024, Номер 7(3), С. e70043 - e70043

Опубликована: Май 29, 2024

Este trabalho investigou o impacto da Sonata K448 de Mozart na recordação memória medo previamente extinta em camundongos, utilizando procedimentos comportamentais e análises estatísticas, buscando compreender os mecanismos envolvidos formação extinção aversiva, com potenciais implicações terapêuticas distúrbios relacionados como transtorno do estresse pós-traumático. Os camundongos foram expostos à música durante a gestação, amamentação fase adulta, seguida por testes condicionamento som/choque, recordação. dados registrados analisados, incluindo medidas congelamento indicador para extinção. A análise estatística avaliou relação temporal efeitos exposição medo. resultados mostraram que não houve diferença significativa entre grupos fêmeas ou machos no teste recordação, indica teve efeito mensurável dos animais ambos sexos, sem disbiose.

Процитировано

0

Feasibility of a Personal Neuromorphic Emulation DOI Creative Commons
Don M. Tucker,

Phan Luu

Entropy, Год журнала: 2024, Номер 26(9), С. 759 - 759

Опубликована: Сен. 5, 2024

The representation of intelligence is achieved by patterns connections among neurons in brains and machines. Brains grow continuously, such that their develop through activity-dependent specification, with the continuing ontogenesis individual experience. theory active inference proposes developmental organization sentient systems reflects general processes informatic self-evidencing, minimization free energy. We interpret this to imply mind may be described information terms are not dependent on a specific physical substrate. At certain level complexity, self-evidencing living (self-organizing) becomes hierarchical reentrant, effective consciousness emerges as consequence good regulator. propose these principles an adequate reconstruction computational dynamics human brain/mind possible sufficient neuromorphic emulation.

Язык: Английский

Процитировано

0