A systematic review and meta‐analysis of respiratory dysfunction in Parkinson's disease

European Journal of Neurology, Год журнала: 2023, Номер 30(5), С. 1481 - 1504

Опубликована: Фев. 13, 2023

Respiratory dysfunction in Parkinson's disease (PD) is common and associated with increased hospital admission mortality rates. Central peripheral mechanisms have been proposed PD. To date no systematic review identifies the extent type of respiratory impairments PD compared healthy controls.PubMed, EMBASE, CINAHL, Web Science, Pedro, MEDLINE, Cochrane Library OpenGrey were searched from inception to December 2021 identify case-control studies reporting measures matched controls.Thirty-nine met inclusion criteria, majority low risk bias across Risk Bias Assessment tool for Non-randomized Studies (RoBANS) domains. Data permitted pooled analysis 26 distinct measures. High-to-moderate certainty evidence impairment was identified vital capacity (standardised mean difference [SMD] 0.75; 95% CI 0.45-1.05; p < 0.00001; I2 = 10%), total chest wall volume (SMD 0.38; 0.09-0.68; 0.01; 0%), maximum inspiratory pressure 0.91; 0.64-1.19; 43%) sniff nasal 0.58; 0.30-0.87; 0%). Sensitivity provided high-moderate forced expiratory 1 s during medication ON phases rate OFF phases. Lower pressure, tidal volume, voluntary ventilation peak cough flow.Strong supports a restrictive pattern muscle weakness controls. Limited data central inconclusive findings.

Язык: Английский

---

Hypoxia Sensing and Responses in Parkinson’s Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1759 - 1759

Опубликована: Фев. 1, 2024

Parkinson’s disease (PD) is associated with various deficits in sensing and responding to reductions oxygen availability (hypoxia). Here we summarize the evidence pointing a central role of hypoxia PD, discuss relation dependence pathological hallmarks including mitochondrial dysfunction, dopaminergic vulnerability, alpha-synuclein-related pathology, highlight link cellular systemic sensing. We describe cases suggesting that may trigger Parkinsonian symptoms but also emphasize endogenous systems protect from can be harnessed PD. Finally, provide examples preclinical clinical research substantiating this potential.

Язык: Английский

---

Respiratory Abnormalities in Parkinson’s Disease: What Do We Know from Studies in Humans and Animal Models?

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(7), С. 3499 - 3499

Опубликована: Март 23, 2022

Parkinson’s disease (PD) is the second most common progressive neurodegenerative characterized by movement disorders due to loss of dopaminergic neurons in ventrolateral region substantia nigra pars compacta (SNpc). Apart from cardinal motor symptoms such as rigidity and bradykinesia, non-motor including those associated with respiratory dysfunction are increasing interest. Not only can they impair patients’ quality life but also cause aspiration pneumonia, which leading death among PD patients. This narrative review attempts summarize existing literature on impairments reported human studies, well what newly known studies animal models disease. Discussed not muscle dysfunction, apnea, dyspnea, altered central control, responses hypercapnia hypoxia, how affected pharmacological treatment PD.

Язык: Английский

---

Eficácia da toxina botulínica no alívio dos sintomas da doença de Parkinson: uma revisão sistemática

Brazilian Journal of Health Review, Год журнала: 2025, Номер 8(1), С. e76648 - e76648

Опубликована: Янв. 10, 2025

A Doença de Parkinson (DP) é uma condição neurodegenerativa progressiva marcada pela perda neurônios dopaminérgicos, resultando em sintomas motores como tremores, rigidez e bradicinesia, além não-motores distúrbios do sono depressão. O tratamento inclui abordagens farmacológicas, a levodopa outros medicamentos que aumentam os níveis dopamina, intervenções não-farmacológicas, exercício físico fisioterapia. importância da toxina botulínica na DP reside sua capacidade proporcionar alívio sintomático significativo com mínimos efeitos colaterais, melhorando qualidade vida dos pacientes. aplicação precisa TB músculos específicos pode ajudar reduzir incapacitantes tratar problemas não-motores, oferecendo abordagem terapêutica complementar muitas vezes essencial no manejo global Parkinson.

---

Trends in mortality and disparities in dilated cardiomyopathy across gender, race, and region in the United States (1999-2020)

Annals of Medicine and Surgery, Год журнала: 2025, Номер 87(3), С. 1589 - 1598

Опубликована: Янв. 30, 2025

Язык: Английский

---

Psychedelics in neuroinflammation: Mechanisms and therapeutic potential

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111278 - 111278

Опубликована: Янв. 1, 2025

Язык: Английский

---

“It’s knowing that there are other people and they’ve accepted it”: Patients’ experiences of an acceptance and commitment therapy group intervention for people with neurological conditions

Neuropsychological Rehabilitation, Год журнала: 2025, Номер unknown, С. 1 - 23

Опубликована: Фев. 3, 2025

Individuals living with neurological conditions often face chronic issues including motor and sensory impairments cognitive deficits. These challenges can lead to significant psychological difficulties, anxiety, depression, post-traumatic stress. Acceptance Commitment Therapy (ACT) is a psychotherapeutic approach which aims enhance flexibility acceptance while promoting behavioural change. Although ACT groups have shown promise in supporting individuals conditions, the evidence on patients' experiences of attending them sparse. This project explored range who had attended group sessions as part routine clinical practice, aim refine future iterations intervention enhancing patient care. Ten individual qualitative semi-structured interviews were carried out data analysed thematically. Three overarching themes emerged from analysis: (1) Initial Barriers Group Attendance Engagement; (2) Building an Environment Acceptance; (3) Developing toolkit. Overall, results showed that led participants develop stronger emotional connectedness, better knowledge their more effective skills, different mindsets regarding condition. Implications for refinement groups, neuropsychological service development, practice are discussed.

Язык: Английский

---

Role of substantia Nigra dopaminergic neurons in respiratory modulation and limitations of levodopa in Parkinson's disease

Experimental Neurology, Год журнала: 2025, Номер 387, С. 115193 - 115193

Опубликована: Фев. 26, 2025

Язык: Английский

---

Interoception in Parkinson's disease: A narrative review and framework for translational research

Autonomic Neuroscience, Год журнала: 2025, Номер 259, С. 103258 - 103258

Опубликована: Март 8, 2025

Язык: Английский

---

Dyspnea and dystussia in Parkinson’s disease: patient-reported prevalence and determinants

Journal of Neurology, Год журнала: 2025, Номер 272(4)

Опубликована: Март 22, 2025

Abstract Background The prevalence of respiratory dysfunction in PD is unknown and a better understanding determinants contributing to important facilitate early recognition treatment. Objective To examine the self-reported symptoms among people with PD. Methods In cross-sectional study, we administered self-completed questionnaire sample 939 persons Respiratory was defined as experiencing at least one following symptoms: breathing difficulties, breathlessness/shortness breath, tightening chest, frequent throat clearing, coughing, or coughing difficulties. A principal component analysis (PCA) used define composite constructs dysfunction. association participant-reported assessed using multivariable logistic regression models (with adjustment for pulmonary diseases COVID-19 symptoms). Results overall rate 44% (42% after excluding COVID-19). PCA resulted two dysfunction: ‘dyspnea’ ‘dystussia’ (an impaired cough response), which together explained 68% total variance. Female sex (OR = 1.39), higher BMI kg/m 2 1.04), longer disease duration 1.35), greater rigidity 1.16), previous disease(s) 7.12), anxiety 1.04) were independently associated ‘dyspnea’. Pulmonary 1.81), 2.20), swallowing complaints 1.48), speech 1.02) ‘dystussia’. Conclusions Dyspnea dystussia are common manifestations deserves more awareness clinical practice. proactive screening dyspnea may contribute earlier treatment

Язык: Английский

---