Dysphagia, Год журнала: 2024, Номер 39(6), С. 1100 - 1111
Опубликована: Март 21, 2024
Язык: Английский
Frontiers in Neurology, Год журнала: 2025, Номер 16
Опубликована: Март 26, 2025
Introduction People with Parkinson’s Disease (PwPD) and an impaired respiratory profile show a lower walking ability. Still, it is unknown if there relationship between ability function that can be used to predict the latter. This cross-sectional study evaluated in PwPD. Methods Seventeen older PwPD, 60 80 years old were asked perform 10-m test at self-selected, fast speed, tests these variables analyzed by multiple linear regression. Results The revealed 44% of patients restrictive, 33% obstructive, 22% mixed. 73% PwPD presented low lung capacity, as demonstrated forced expiratory volume 1 s divided vital capacity (FEV1/FVC). Multiple regression self-selected speed explained 53 58% ( p = 0.027 0.016) variation maximal inspiratory pressures, respectively. 62 66% 0.008 0.005) pressure variation, Furthermore, locomotor rehabilitation index 39% 0.022) variance FEV1/FVC. Conclusion These results suggest ability, particularly speeds, suitable screening parameter for pulmonary impairments indicates expire rapidly proportion Thus, easily applicable low-cost biomarker assessing changes
Язык: Английский
Процитировано
0
Molecules, Год журнала: 2025, Номер 30(8), С. 1672 - 1672
Опубликована: Апрель 8, 2025
Parkinson’s disease (PD) is a complex neurodegenerative disorder with debilitating non-motor symptoms, including gastrointestinal dysfunction, cardiovascular abnormalities, mood and anxiety disorders, cognitive decline, sleep disturbances, respiratory pain. Despite their significant impact on quality of life, these symptoms are often inadequately addressed. Propolis natural bee-derived product, rich in bioactive compounds anti-inflammatory, antioxidant, immunomodulatory, neuroprotective properties, which holds potential PD due to its multitarget multipathway actions, addressing various underlying mechanisms symptom diseases. Preclinical clinical studies suggest that propolis may influence key pathological PD’s symptoms. Evidence points benefits improving cognition, health, alleviating sleep-related issues. Although research remains scarce, findings from related conditions ability associated This review underscores the underexplored therapeutic PD, drawing existing evidence advocating for further fully assess role patient outcomes.
Язык: Английский
Процитировано
0
Neuroscience Applied, Год журнала: 2024, Номер 3, С. 104061 - 104061
Опубликована: Янв. 1, 2024
Parkinson's disease (PD) is a neurological disorder that often affects middle-aged and elderly people. It primarily characterized by the degeneration of dopaminergic (DA) neurons in ventral midbrain. Clinical therapy mostly relies on holistic approach pharmaceutical intervention surgical procedures. Nevertheless, therapies might just alleviate symptoms temporarily then result notable adverse consequences, ultimately failing to produce therapeutic outcome. Stem cells has benefits being capable self-renewal exhibiting multi-directional differentiation potential. This enables replacement dysfunctional reconstruction neural circuit, offering promise for treatment disease. research examines evaluates fundamental principles, effectiveness, benefits, drawbacks various stem cell types review provides concise summary many potential processes which be effective treating The aim support ongoing clinical trials focused using
Язык: Английский
Процитировано
2
iScience, Год журнала: 2024, Номер 27(11), С. 111251 - 111251
Опубликована: Окт. 24, 2024
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4403 - 4403
Опубликована: Апрель 17, 2024
In Parkinson's disease (PD), along with typical motor dysfunction, abnormal breathing is present; the cause of which not well understood. The study aimed to analyze effects stimulation serotonergic system 5-HT1A and 5-HT2A agonists in a model PD induced by injection 6-hydroxydopamine (6-OHDA). To PD, bilateral 6-OHDA into both striata was performed male Wistar rats. Respiratory disturbances response 7% hypercapnia (CO2 O2) plethysmographic chamber before after incidence apnea were studied awake rats 5 weeks or vehicle injection. Administration reduced concentration serotonin (5-HT), dopamine (DA) norepinephrine (NA) striatum level 5-HT brainstem treated rats, have been associated decreased basal ventilation, impaired respiratory CO2 increased compared Sham-operated Intraperitoneal (i.p.) 5-HT1AR agonist 8-OH-DPAT 5-HT2AR NBOH-2C-CN during normocapnia groups However, it restored reactivity group present Sham Another TCB-2 only effective increasing normocapnic ventilation Both had stronger stimulatory on respiration compensating for deficits hypercapnic respiration. We conclude that may positive effect impairments occur PD.
Язык: Английский
Процитировано
2
Journal of Dynamic Systems Measurement and Control, Год журнала: 2024, Номер 147(2)
Опубликована: Авг. 20, 2024
Abstract Existing noninvasive breathing assist options compatible with out-of-hospital settings are limited and not appropriate to enable essential everyday activities, thereby deteriorating the quality of life. In our prior work, we developed Exo-Abs, a novel wearable robotic platform for ubiquitous assistance respiratory functions in patients deficiency. This paper concerns development model-based closed-loop control algorithm Exo-Abs automate its assistance. To facilitate algorithms, control-oriented mathematical model Exo-Abs. Then, robust absolutely stabilizing gain-scheduled proportional-integral automating by (i) solving linear matrix inequality formulation Lyapunov stability condition against sector-bounded uncertainty interindividual variability mechanics abdomen lungs (ii) augmenting it heuristic yet effective gain scheduling algorithm. Using silico evaluation based on realistic plausible virtual patients, demonstrated efficacy robustness automated under wide range spontaneous efficiency: resulted small exhalation trajectory tracking error (<30 ml) smooth actuation, which was superior counterpart proportional-integral-derivative chattering.
Язык: Английский
Процитировано
2
Neuroscience, Год журнала: 2023, Номер 512, С. 32 - 46
Опубликована: Янв. 20, 2023
Язык: Английский
Процитировано
5
Experimental Neurology, Год журнала: 2024, Номер 375, С. 114740 - 114740
Опубликована: Фев. 21, 2024
Parkinson's disease (PD) is the second most frequent neurodegenerative disorder. Besides major deficits in motor coordination, patients may also display sensory and cognitive impairments, which are often overlooked despite being inherently part of PD symptomatology. Amongst those symptoms, respiration, a key mechanism involved regulation multiple physiological neuronal processes, appears to be altered. Importantly, breathing patterns highly correlated with animal's behavioral states. This raises question potential impact state on respiration PD. To answer this question, we first characterized respiratory parameters neurotoxin-induced rat model (6-OHDA) across three different vigilance states: sleep, quiet waking exploration. We noted significantly higher frequency 6-OHDA rats during compared Sham rats. A amplitude was observed both No effect treatment sleep. Given relation between olfaction presence olfactory patients, then investigated odor-evoked sniffing response rats, using an odor habituation/cross-habituation paradigm. substantial differences were abilities two groups, as assessed through frequency. These results corroborate hypothesis that impairments vigilance-dependent. Our shed light importance considering impacting factor when analyzing respiration.
Язык: Английский
Процитировано
1
PLoS ONE, Год журнала: 2024, Номер 19(3), С. e0301433 - e0301433
Опубликована: Март 29, 2024
Respiratory disorders are the most common cause of death in Parkinson's Disease (PD). Conflicting data exist on aetiology respiratory dysfunction PD and few studies examine effects exercise-based interventions measures. This study was conducted to better understand identify measures responsive an integrative exercise programme.
Язык: Английский
Процитировано
1
Journal of Parkinson s Disease, Год журнала: 2024, Номер 14(7), С. 1427 - 1439
Опубликована: Сен. 10, 2024
The association of lung function with the risk developing prodromal and clinical-diagnosed Parkinson's disease (PD) mortality among individuals PD remains unknown.
Язык: Английский
Процитировано
1