High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117833 - 117833

Опубликована: Фев. 1, 2025

The increasing prevalence of acute noise exposure poses a significant threat to mental health. Identifying the intensity that impair health is crucial for developing effective interventions. study aimed determine thresholds elicit anxiety-like behaviors and brain damage in female rats, then elucidate underlying neurobiological mechanisms. Female rats were subjected at levels 105, 115, 125, 135 dB assessed 3th day 1 month post-exposure. We found induced hippocampal neuron apoptosis on third day, with these effects persisting up one after exposure. KEGG enrichment analysis differentially expressed genes (DEGs) revealed alterations PI3K-AKT signaling pathway, as confirmed by Western blot analysis. Our findings indicate elicits post-exposure, month. This sustained anxiety attributed inhibition pathway subsequent activation apoptotic Caspase-3/BCL-2/BAX culminating apoptosis.

Язык: Английский

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Acute high-intensity noise exposure exacerbates anxiety-like behavior via neuroinflammation and blood brain barrier disruption of hippocampus in male rats

Behavioral and Brain Functions, Год журнала: 2025, Номер 21(1)

Опубликована: Апрель 22, 2025

The health risks associated with acute noise exposure are increasing, particularly the risk of mental health. This study aims to identify association between high-intensity and anxiety behavior in male rats, explore neurobiological mechanisms. Male rats were subjected different levels determine intensity that causes long-lasting anxiety-like behaviors. Anxiety-like behaviors evaluated using open field test (OFT) elevated plus maze (EPMT) on third day 1month post-exposure, respectively. A range techniques, including immunofluorescence staining, western blot, ELISA, real-time quantitative PCR, used investigate neuronal apoptosis, glial cell activation, neuroinflammation, blood-brain barrier (BBB) disruption hippocampus. Upon 135 dB noise, exhibited enduring Subsequent investigations discovered this not only activated cells triggered neuroinflammation within hippocampus but also decreased expression ZO-1, claudin-5, occludin, suggesting a BBB. Additionally, was induction apoptosis hippocampal region. In conclusion, may cause persistent through cyclical interaction BBB disruption, potentially leading apoptosis.

Язык: Английский

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Noise exposure-induced the cerebral alterations: From emerging evidence to antioxidant-mediated prevention and treatment

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 288, С. 117411 - 117411

Опубликована: Ноя. 25, 2024

Язык: Английский

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Occupational noise in dentistry

BDJ, Год журнала: 2024, Номер 237(6), С. 434 - 434

Опубликована: Сен. 27, 2024

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