Physiology, Год журнала: 2024, Номер 39(4), С. 178 - 178
Опубликована: Май 30, 2024
Язык: Английский
Autophagy, Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
Macropinocytosis is a nonselective form of endocytosis that allows cancer cells to largely take up the extracellular fluid and its contents, including nutrients, growth factors, etc. We first elaborate meticulously on process macropinocytosis. Only by thoroughly understanding this entire can we devise targeted strategies against it. then focus central role MTOR (mechanistic target rapamycin kinase) complex 1 (MTORC1) in regulating macropinocytosis, highlighting significance as key signaling hub where various pathways converge control nutrient uptake metabolic processes. The article covers comprehensive analysis literature molecular mechanisms governing initiation, maturation, recycling macropinosomes, with an emphasis how these processes are hijacked sustain their growth. Key discussions include potential therapeutic targeting such enhancing drug delivery via pathway, inhibiting macropinocytosis starve cells, blocking degradation inducing methuosis – cell death triggered excessive Targeting represents novel innovative approach could significantly advance treatment cancers rely pathway for survival. Through continuous research innovation, look forward developing more effective safer anti-cancer therapies will bring new hope patients.
Язык: Английский
Процитировано
1
BioEssays, Год журнала: 2025, Номер unknown
Опубликована: Март 31, 2025
ABSTRACT Recent studies show the importance of mesoscale changes to plasma membrane (PM) topography during cell shape change. Local folding and flattening surface is mechanosensitive, changing in response both microenvironment structural elements intracellular cytoskeletal activities. These elicit local mechanical signaling events that act conjunction with molecular signal transduction pathways remodel cortex. Experimental manipulations PM curvature its sufficiency for recruiting Arp2/3 actin network induction pathways. Additionally, diverse changes—ranging from neutrophil migration early Drosophila embryo cleavage neural stem asymmetric division—show generation linked induction, which then remodels dynamic control structure. examples are reviewed detail, together known potential causes changes, downstream effects, higher‐order feedback.
Язык: Английский
Процитировано
0
Food Bioscience, Год журнала: 2025, Номер unknown, С. 106648 - 106648
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101922 - 101922
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июль 16, 2024
Abstract Tension propagates in lipid bilayers over hundreds of microns within milliseconds, precluding the formation tension gradients. Nevertheless, plasma membrane gradients have been evidenced migrating cells and along axons. Here, using a fluorescent probe, we show that exist all adherent cells, whether they migrate or not. Non-adhering do not display We further branched actin increases tension, while membrane-to-cortex attachments facilitate its propagation. is lowest at edge adhesion sites highest protrusions, setting boundaries By providing quantitative mechanistic basis behind organization gradients, our work explains how are actively sustained cells.
Язык: Английский
Процитировано
1
Physiology, Год журнала: 2024, Номер 39(4), С. 178 - 178
Опубликована: Май 30, 2024
Язык: Английский
Процитировано
0