Application of lipopolysaccharide in establishing inflammatory models
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
279, С. 135371 - 135371
Опубликована: Сен. 6, 2024
Язык: Английский
Micronutrient (iron, selenium, vitamin D) supplementation and the gut microbiome
Current Opinion in Clinical Nutrition & Metabolic Care,
Год журнала:
2024,
Номер
27(5), С. 421 - 427
Опубликована: Май 21, 2024
Purpose
of
review
Deficiencies
in
micronutrients
persist
as
widespread
global
challenges,
where
supplementation
remains
a
crucial
therapeutic
approach.
This
aims
to
elucidate
the
intricate
relationships
between
micronutrient
–
specifically
iron,
selenium
(Se),
and
vitamin
D
(Vit
D)
gut
microbiota
composition,
investigating
their
collective
impact
on
host
health
disease
susceptibility.
Recent
findings
Maintaining
balanced
iron
levels
is
essential
for
equilibrium
health,
both
deficiency
excess
disrupt
bacterial
balance,
affecting
colon
health.
Se
can
restore
improve
microbial
influencing
outcomes
not
only
but
also
areas
such
neuroprotection
brain,
testicular
metabolic
syndrome.
Clinical
experimental
models
demonstrate
that
Vit
modulates
microbiome,
enhancing
anti-inflammatory
effects,
supporting
potentially
reducing
risk
gut-related
behavioral
changes
diseases.
Summary
Findings
this
emphasize
are
maintaining
healthy
composition
underscore
beneficial
effects
modulating
microbiome.
The
interactions
microbiome
complex
may
have
broad
spectrum
outcomes.
Язык: Английский
Immune and metabolic challenges induce changes in pain sensation and related pathways in the hypothalamus
Physiological Genomics,
Год журнала:
2024,
Номер
56(4), С. 343 - 359
Опубликована: Янв. 8, 2024
The
hypothalamic
molecular
processes
participate
in
the
regulation
of
neuro-immune-endocrine
system,
including
hormone,
metabolite,
chemokine
circulation,
and
corresponding
physiological
behavioral
responses.
RNA-sequencing
profiles
were
analyzed
to
understand
effect
juvenile
immune
metabolic
distress
100
days
after
virally
elicited
maternal
activation
during
gestation
pigs.
Over
1,300
genes
exhibited
significant
additive
or
interacting
effects
gestational
activation,
distress,
sex.
One-third
these
presented
multiple
effects,
emphasizing
complex
interplay
factors.
Key
functional
categories
enriched
among
affected
included
sensory
perception
pain,
steroidogenesis,
prolactin,
neuropeptide,
inflammatory
signaling.
These
underscore
intricate
relationship
between
gestation,
response
pathways
insults.
sex-dependent
for
many
genes,
such
as
Язык: Английский
Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury
Microbiology Spectrum,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
ABSTRACT
Acute
lung
injury
(ALI)
is
associated
with
high
morbidity
and
mortality
rates.
However,
its
clinical
treatment
limited.
Currently,
the
of
diseases
by
regulating
microbiota
has
become
a
research
hotspot.
In
this
study,
we
investigated
protective
effects
intranasal
administration
Clostridium
butyricum
derived
extracellular
vesicles
(EVs)
against
lipopolysaccharide
(LPS)-induced
ALI.
The
results
demonstrated
that
compared
LPS
group,
pre-treatment
group
C.
EVs
reduced
expression
pro-inflammatory
cytokines
alleviated
symptoms
in
ALI
mice
inhibiting
TLR4/MyD88
signaling
pathway.
Moreover,
inhibited
apoptosis-related
proteins
increased
barrier
proteins.
Additionally,
intervention
changed
composition
pulmonary
microbiota.
At
species
level,
significantly
relative
abundance
Acinetobacter
johnsonii
,
while
reversed
effect.
conclusion,
these
data
demonstrate
can
prevent
LPS-induced
reducing
inflammation,
apoptosis,
improving
function.
regulated
to
alleviate
IMPORTANCE
disorder
plays
an
important
role
progression
acute
(ALI).
very
few
studies
have
been
conducted
treat
modulating
diversity
were
altered
mice,
but
ecological
balance
was
restored
.
study
reported
mechanism
for
These
reveal
importance
disease.
It
provides
new
approach
new-generation
probiotics.
Язык: Английский
Vitamin D promotes autophagy to inhibit LPS-induced lung injury via targeting cathepsin D
Zhanglei Xu,
Jinling Luan,
Fengyun Wan
и другие.
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Язык: Английский
Uterine Blood Flow Dynamic Changes in Sprague-Dawley Rats During Pregnancy Using Noninvasive Color Doppler Sonography
Egyptian Journal of Veterinary Science,
Год журнала:
2023,
Номер
55(1), С. 259 - 269
Опубликована: Окт. 13, 2023
T
HE
present
study
was
designed
to
evaluate
the
changes
of
uterine
blood
flow
during
pregnancy
in
Sprague-Dawley.Also,
investigate
clinical
applicability
noninvasive
color
Doppler
ultrasound
charactrize
indices
maternal
arteries
rats.Ten
female
rats
weighing
280-300
gm
were
used
and
volume
(BFV),
time
averaged
maximum
velocity
(TAMV),
peak
systolic
(PSV),
resistance
index
(RI),
pulsatility
(PI),
diameter
(D)
pregnancy.Examination
started
three
days
after
breeding
continued
at
7,
14
18.Based
on
doppler
sonography,
BFV,
TAMV,
PSV
increased
significantly
all-time
points
examination.On
contrary,
RI
PI
decreased
steadily
points.The
showed
a
significant
increase
day
20
gestation.Altogether,
these
results
indicate
that
non-invasive
parameters
provide
important
information
toward
understanding
vasculature
its
perfusion
uterus
period
rats.Furthermore,
would
be
key
values
for
Sprague-Dawley.
Язык: Английский