CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(3)
Опубликована: Март 1, 2024
Parkinson's
disease
(PD)
is
a
progressive
neurodegenerative
brain
due
to
degeneration
of
dopaminergic
neurons
(DNs)
presented
with
motor
and
non-motor
symptoms.
PD
symptoms
are
developed
in
response
the
disturbance
diverse
neurotransmitters
including
γ-aminobutyric
acid
(GABA).
GABA
has
neuroprotective
effect
against
neuropathology
by
protecting
DNs
substantia
nigra
pars
compacta
(SNpc).
It
been
shown
that
GABAergic
linked
progression
neurotransmission
necessary
pathway
for
normal
sleep
patterns,
thus
deregulation
could
be
potential
cause
disorders
PD.
Frontiers in Cellular Neuroscience,
Год журнала:
2022,
Номер
16
Опубликована: Июль 29, 2022
Gamma
oscillation
is
the
synchronization
with
a
frequency
of
30-90
Hz
neural
oscillations,
which
are
rhythmic
electric
processes
neuron
groups
in
brain.
The
inhibitory
interneuron
network
necessary
for
production
gamma
but
certain
disruptions
such
as
brain
inflammation,
oxidative
stress,
and
metabolic
imbalances
can
cause
this
to
malfunction.
oscillations
specifically
control
connectivity
between
different
regions,
crucial
perception,
movement,
memory,
emotion.
Studies
have
linked
abnormal
conditions
central
nervous
system,
including
Alzheimer's
disease,
Parkinson's
schizophrenia.
Evidence
suggests
that
entrainment
using
sensory
stimuli
(GENUS)
provides
significant
neuroprotection.
This
review
discusses
function
advanced
activities
from
both
physiological
pathological
standpoint,
it
emphasizes
potential
therapeutic
approach
range
neuropsychiatric
diseases.
Neuron,
Год журнала:
2023,
Номер
111(20), С. 3154 - 3175
Опубликована: Июль 18, 2023
One
of
the
most
captivating
questions
in
neuroscience
revolves
around
brain's
ability
to
efficiently
and
durably
capture
store
information.
It
must
process
continuous
input
from
sensory
organs
while
also
encoding
memories
that
can
persist
throughout
a
lifetime.
What
are
cellular-,
subcellular-,
network-level
mechanisms
underlie
this
remarkable
capacity
for
long-term
information
storage?
Furthermore,
what
contributions
do
distinct
types
GABAergic
interneurons
make
process?
As
hippocampus
plays
pivotal
role
memory,
our
review
focuses
on
three
aspects:
(1)
delineation
hippocampal
interneuron
their
connectivity,
(2)
plasticity,
(3)
activity
patterns
during
memory-related
rhythms,
including
long-range
disinhibition.
We
explore
how
these
elements,
together
showcasing
diversity
inhibitory
circuits,
shape
processing
hippocampus.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Дек. 8, 2023
Spatial
transcriptomics
(ST)
technologies
enable
high
throughput
gene
expression
characterization
within
thin
tissue
sections.
However,
comparing
spatial
observations
across
sections,
samples,
and
remains
challenging.
To
address
this
challenge,
we
develop
STalign
to
align
ST
datasets
in
a
manner
that
accounts
for
partially
matched
sections
other
local
non-linear
distortions
using
diffeomorphic
metric
mapping.
We
apply
as
well
3D
common
coordinate
framework.
show
achieves
cell-type
correspondence
locations
is
significantly
improved
over
landmark-based
affine
alignments.
Applying
of
the
mouse
brain
framework
from
Allen
Brain
Atlas,
highlight
how
can
be
used
lift
region
annotations
interrogation
compositional
heterogeneity
anatomical
structures.
available
an
open-source
Python
toolkit
at
https://github.com/JEFworks-Lab/STalign
Supplementary
Software
with
additional
documentation
tutorials
https://jef.works/STalign
.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(3)
Опубликована: Март 1, 2024
Parkinson's
disease
(PD)
is
a
progressive
neurodegenerative
brain
due
to
degeneration
of
dopaminergic
neurons
(DNs)
presented
with
motor
and
non-motor
symptoms.
PD
symptoms
are
developed
in
response
the
disturbance
diverse
neurotransmitters
including
γ-aminobutyric
acid
(GABA).
GABA
has
neuroprotective
effect
against
neuropathology
by
protecting
DNs
substantia
nigra
pars
compacta
(SNpc).
It
been
shown
that
GABAergic
linked
progression
neurotransmission
necessary
pathway
for
normal
sleep
patterns,
thus
deregulation
could
be
potential
cause
disorders
PD.
